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Generic Name: betamethasone and clotrimazole topical (BAY ta METH a sone and kloe TRIM a zole TOP ik al)
Brand Names: Lotrisone
Lotrisone is used to treat fungal skin infections such as athletes foot, jock itch, and ringworm. Learn about side effects, interactions and indications.

Average Savings for clotrimazole/betamethason (generic): 30.76%
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Drug Information:
Lotrisone cream contains a combination of Betamethasone and clotrimazol. Betamethasone is steroid that reduces itching, swelling, and redness of the skin. Clotrimazole is an antifungal medication that fights infections caused by fungus. Lotrisone cream is used to treat fungal skin infections such as athlete's foot, jock itch, and ringworm. Lotrisone may also be used for purposes not listed in this medication guide. Do not cover treated skin areas with a bandage or tight clothing, unless your doctor has told you to. Learn more

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Lotrisone Side Effects

Note: This document contains side effect information about betamethasone / clotrimazole topical. Some of the dosage forms listed on this page may not apply to the brand name Lotrisone.

In Summary

Common side effects of Lotrisone include: adrenal suppression. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to betamethasone/clotrimazole topical: topical cream, topical lotion

Along with its needed effects, betamethasone/clotrimazole topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking betamethasone/clotrimazole topical:

Less common

  • Blistering, burning, itching, peeling, dryness, redness, or other signs of skin irritation not present before use of this medicine
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • hives


  • Chills
  • cough
  • fever
  • hoarseness
  • lower back or side pain
  • painful or difficult urination
  • rash
  • stinging
  • swelling

Incidence not known

  • Blindness
  • blurred vision
  • change in vision
  • decreased vision
  • dry mouth
  • eye pain
  • full or round face, neck, or trunk
  • headache
  • irritability
  • nausea
  • reddish purple lines on the arms, face, legs, trunk, or groin
  • redness and scaling around the mouth
  • softening of the skin
  • stomach pain
  • tearing
  • unusual tiredness or weakness
  • vomiting

For Healthcare Professionals

Applies to betamethasone / clotrimazole topical: topical cream, topical lotion


The most frequently reported side effects are rash, edema, paresthesia, and secondary infections.


Topical corticosteroids:

-Frequency not reported: Burning, itching, irritation, dryness, folliculitis, blistering, peeling, redness, swelling, hypertrichosis, acneiform eruptions, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, secondary infection, skin atrophy, striae, miliaria, irritation, telangiectasia, sensitization


Frequency not reported: Hypothalamic-pituitary adrenal (HPA) axis suppression, Cushing's syndrome

Nervous system

Common (1% to 10%): Paresthesia

Frequency not reported: Intracranial hypertension


Frequency not reported: Growth retardation


Frequency not reported: Rash, maculopapular rash

Betamethasone dipropionate:

-Frequency not reported: Burning, itching, irritation, dryness, folliculitis, hypertrichosis, acneiform eruptions, hyperpigmentation, hypopigmentation, perioral dermatitis, allergic contact dermatitis, maceration of the skin, skin atrophy, striae miliaria, ecchymoses, telangiectasia


-Frequency not reported: Erythema, stinging, blistering, peeling, pruritus, urticaria, general irritation


Betamethasone dipropionate:

-Frequency not reported: Sensitization


Topical corticosteroids:

-Frequency not reported: Glucosuria


Betamethasone dipropionate:

-Frequency not reported: Blurred vision


Topical corticosteroids:

-Frequency not reported: Hyperglycemia


Frequency not reported: Edema, secondary infection

Betamethasone dipropionate:

-Frequency not reported: Secondary infection


-Frequency not reported: Edema

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Lotrisone (www.drugs.com/lotrisone.html).