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Lotrel Prescription
Generic Name: amlodipine and benazepril (am LOE di peen and ben AY ze pril)
Brand Names: Lotrel
Lotrel (amlodipine and benazepril) is used to treat high blood pressure (hypertension). Includes Lotrel side effects, interactions and indications.

Average Savings for amlodipine besylate/benaz (generic): 55.42%
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Lotrel Drug Information:

Lotrel contains a combination of amlodipine and benazepril. Amlodipine is a calcium channel blocker. Amlodipine relaxes (widens) blood vessels and improves blood flow. Benazepril is an ACE inhibitor. ACE stands for angiotensin converting enzyme. Benazepril also widens blood vessels and also prevents the body from retaining water. Lotrel is used to treat high blood pressure (hypertension). Lotrel may also be used for purposes not listed in this medication guide. Do not use Lotrel if you are pregnant. If you become pregnant, stop taking this medicine and tell your doctor right away. Learn more

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Lotrel Side Effects

Note: This document contains side effect information about amlodipine / benazepril. Some of the dosage forms listed on this page may not apply to the brand name Lotrel.

For the Consumer

Applies to amlodipine / benazepril: oral capsule


Oral route (Capsule)

Discontinue amlodipine besylate/benazepril hydrochloride as soon as possible if pregnancy is detected. This drug can cause injury and death to the fetus.

Along with its needed effects, amlodipine / benazepril may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking amlodipine / benazepril:

Less common

  • Confusion
  • dizziness, lightheadedness, or fainting
  • fast or irregular heartbeat
  • nervousness
  • numbness or tingling in the hands, feet, or lips
  • swelling of the ankles, feet, or lower legs
  • weakness or heaviness of the legs


  • Bleeding gums
  • chills
  • fever
  • nausea or vomiting
  • nosebleeds
  • pale skin
  • sores, ulcers, or white spots on the lips, tongue, or inside the mouth
  • stomach pain or bloating with fever, nausea, or vomiting
  • swelling of the face, mouth, hands, or feet
  • trouble with swallowing or breathing (sudden) or hoarseness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • yellow eyes or skin

Incidence not known

  • Chest pain
  • heartburn
  • pain or burning in the throat

Some side effects of amlodipine / benazepril may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Cough (dry and continuous)
  • feeling of warmth
  • redness of the face, neck, arms, and occasionally upper chest
  • sleepiness

Incidence not known

  • Belching
  • blistering, crusting, irritation, itching, or reddening of the skin
  • body aches or pain
  • cracked, dry, or scaly skin
  • decreased interest in sexual intercourse
  • difficulty having a bowel movement
  • frequent urination
  • inability to have or keep an erection
  • increased volume of pale, dilute urine
  • indigestion
  • lack or loss of strength
  • loss in sexual ability, desire, drive, or performance
  • muscle or bone pain
  • shakiness in the legs, arms, hands, or feet
  • stomach discomfort or upset
  • sudden sweating
  • swelling
  • tender, swollen glands in the neck
  • trembling or shaking of the hands or feet
  • trouble with sleeping
  • voice changes

For Healthcare Professionals

Applies to amlodipine / benazepril: oral capsule


The most common side effects were cough, headache, dizziness, and edema.

Nervous system

Common (1% to 10%): Headache, dizziness

Frequency not reported: Tremor


Common (1% to 10%): Headache, dizziness

Postmarketing reports: Dysgeusia, hypoesthesia, paresthesia, syncope, peripheral neuropathy, hypertonia


Common (1% to 10%): Headache, dizziness

Postmarketing reports: Paresthesia, dysgeusia


Common (1% to 10%): Cough

Frequency not reported: Pharyngitis


Uncommon (0.1% to 1%): Cough

Postmarketing reports: Rhinitis


Common (1% to 10%): Cough


Common (1% to 10%): Edema

Frequency not reported: Asthenia, fatigue


Common (1% to 10%): Edema

Postmarketing reports: Malaise


Uncommon (0.1% to 1%): Edema

Amlodipine-induced peripheral edema is dose dependent. Benazepril reduces the incidence of edema when added to amlodipine.


Frequency not reported: Impotence, polyuria


Postmarketing reports: Micturition disorder, nocturia, erectile dysfunction


Frequency not reported: Dry mouth, nausea, abdominal pain, constipation, diarrhea, dyspepsia, esophagitis


Postmarketing reports: Gingival hyperplasia, gastritis


Frequency not reported: Back pain, musculoskeletal pain, cramps, muscle cramps


Postmarketing reports: Muscle spasms, arthralgia


Postmarketing reports: Arthralgia, arthritis, myalgia


Frequency not reported: Rash, skin nodule, dermatitis


Postmarketing reports: Hyperhidrosis, pruritus, skin discoloration, urticaria, erythema multiform


Postmarketing reports: Stevens-Johnson syndrome, pemphigus, pruritus, photosensitivity reaction


Frequency not reported: Insomnia, nervousness, anxiety, libido decreased


Frequency not reported: Flushing, hot flashes


Postmarketing reports: Tachycardia, hypotension, vasculitis


Postmarketing reports: Orthostatic symptoms, hypotension, angina pectoris, arrhythmia



Postmarketing reports: Visual impairment, diplopia


Postmarketing reports: Impaired vision


Frequency not reported: Hypokalemia


Postmarketing reports: Hyperglycemia, weight decrease or gain



Postmarketing reports: Allergic reaction



Postmarketing reports: Serum creatinine increased, BUN increased, renal impairment


Frequency not reported: Neutropenia


Postmarketing reports: Leucocytopenia


Postmarketing reports: Hemolytic anemia, thrombocytopenia, agranulocytosis, neutropenia



Postmarketing reports: Jaundice, hepatic enzyme elevations


Postmarketing reports: Pancreatitis

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Lotrel (www.drugs.com/lotrel.html).