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Lorazepam belongs to a group of drugs called benzodiazepines. It affects chemicals in the brain that may be unbalanced in people with anxiety.
Lorazepam is used to treat anxiety disorders and seizure disorders.
Lorazepam may also be used for purposes not listed in this medication guide.
You should not use lorazepam if you have narrow-angle glaucoma, severe respiratory insufficiency, myasthenia gravis, or if you are allergic to Valium or a similar medicine.
Do not use lorazepam if you are pregnant. This medicine can cause birth defects or life-threatening withdrawal symptoms in a newborn.
Lorazepam may be habit-forming and should be used only by the person it was prescribed for. Misuse of habit-forming medicine can cause addiction, overdose, or death. Lorazepam should never be shared with another person, especially someone who has a history of drug abuse or addiction. Keep the medication in a secure place where others cannot get to it.
Do not drink alcohol while taking lorazepam. This medication can increase the effects of alcohol.
It is dangerous to purchase lorazepam on the Internet or from vendors outside the United States. Medications distributed from Internet sales may contain dangerous ingredients, or may not be distributed by a licensed pharmacy. The sale and distribution of lorazepam outside the U.S. does not comply with the regulations of the Food and Drug Administration (FDA) for the safe use of this medication.
You should not take lorazepam if you have:
narrow-angle glaucoma;
severe respiratory insufficiency;
myasthenia gravis; or
a history of allergic reaction to any benzodiazepine, such as diazepam (Valium), chlordiazepoxide, clonazepam, flurazepam, and others.
To make sure lorazepam is safe for you, tell your doctor if you have:
seizures or epilepsy;
kidney or liver disease (especially alcoholic liver disease);
asthma or other breathing disorder;
open-angle glaucoma;
a history of depression or suicidal thoughts or behavior;
a history of drug or alcohol addiction; or
if you use a narcotic (opioid) medication.
Do not use lorazepam if you are pregnant. This medicine can cause birth defects. Your baby could also become dependent on the drug. This can cause life-threatening withdrawal symptoms in the baby after it is born. Babies born dependent on habit-forming medicine may need medical treatment for several weeks. Tell your doctor if you are pregnant or plan to become pregnant. Use effective birth control to prevent pregnancy while you are taking lorazepam.
Lorazepam can pass into breast milk and may harm a nursing baby. Talk to your doctor before breastfeeding while you are using this medicine.
Lorazepam is not FDA approved for use by anyone younger than 18 years old.
The sedative effects of lorazepam may last longer in older adults. Accidental falls are common in elderly patients who take benzodiazepines. Use caution to avoid falling or accidental injury while you are taking lorazepam.
Take lorazepam exactly as it was prescribed for you. Follow all directions on your prescription label. Never use this medicine in larger amounts, or for longer than prescribed. Tell your doctor if the medicine seems to stop working as well in treating your symptoms.
Lorazepam may be habit-forming. Never share this medicine with another person, especially someone with a history of drug abuse or addiction. Keep the medication in a place where others cannot get to it.
Misuse of habit-forming medicine can cause addiction, overdose, or death. Selling or giving away this medicine is against the law.
Measure liquid medicine with the dosing syringe provided, or with a special dose-measuring spoon or medicine cup. If you do not have a dose-measuring device, ask your pharmacist for one.
Lorazepam should be used for only a short time. Do not take this medicine for longer than your doctor recommends.
Do not stop using lorazepam suddenly or you could have unpleasant withdrawal symptoms, including a seizure (convulsions). Ask your doctor how to safely stop using this medicine.
Call your doctor if this medicine seems to stop working as well in treating your anxiety symptoms.
Keep track of the amount of medicine used from each new bottle. Lorazepam is a drug of abuse and you should be aware if anyone is using your medicine improperly or without a prescription.
Store lorazepam tablets at room temperature away from moisture, heat, and light. Store the liquid form of this medicine in the refrigerator.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. An overdose of lorazepam can be fatal. Overdose symptoms may include extreme drowsiness, confusion, muscle weakness, loss of balance or coordination, feeling light-headed, and fainting.
Avoid drinking alcohol. Dangerous side effects could occur.
Lorazepam may impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you. Dizziness or severe drowsiness can cause falls or other accidents.
Get emergency medical help if you have signs of an allergic reaction to lorazepam: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have:
severe drowsiness;
thoughts of suicide or hurting yourself;
unusual changes in mood or behavior;
confusion, aggression, hallucinations;
worsened sleep problems;
sudden restless feeling or excitement;
muscle weakness, drooping eyelids, trouble swallowing;
vision changes; or
upper stomach pain, dark urine, jaundice (yellowing of the skin or eyes).
Common lorazepam side effects may include:
dizziness, drowsiness;
weakness;
slurred speech, lack of balance or coordination;
memory problems; or
feeling unsteady.
This is not a complete list of side effects and others may occur. Tell your doctor about any unusual or bothersome side effect. You may report side effects to FDA at 1-800-FDA-1088.
Taking this medicine with other drugs that make you sleepy or slow your breathing can cause dangerous side effects or death. Ask your doctor before taking lorazepam with a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression or seizures.
Tell your doctor about all your current medicines and any you start or stop using, especially:
any other medicines to treat anxiety;
probenecid;
aminophylline or theophylline;
an antidepressant, or medicine to treat mental illness;
a barbiturate such as phenobarbital;
narcotic pain medicine;
seizure medicine; or
medicine that contains an antihistamine (such as sleep medicine, cold or allergy medicine).
This list is not complete. Other drugs may interact with lorazepam, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use lorazepam only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Lorazepam Intensol (www.drugs.com/lorazepam.html).
Commonly reported side effects of lorazepam include: sedated state. Other side effects include: dizziness. See below for a comprehensive list of adverse effects.
Applies to lorazepam: oral solution, oral tablet
Other dosage forms:
Oral route (Tablet)
Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Reserve use where alternative treatments are inadequate. Limit the dosage and duration, and monitor signs and symptoms.
Along with its needed effects, lorazepam may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking lorazepam:
More common
Incidence not known
Get emergency help immediately if any of the following symptoms of overdose occur while taking lorazepam:
Symptoms of overdose
Some side effects of lorazepam may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
Applies to lorazepam: compounding powder, injectable solution, intravenous solution, oral concentrate, oral tablet
Oral: The most commonly reported side effects included sedation, dizziness, weakness, and unsteadiness.
Parenteral: The most commonly reported side effects included somnolence, respiratory failure, hypotension, and injection site reactions (pain and burning).
Parenteral:
Very common (10% or more): Burning (up to 17%), pain (up to 17%)
Common (1% to 10%): Painful response, redness
Uncommon (0.1% to 1%): Injection site reaction
Frequency not reported: Arteriospasm, gangrene, injection site tolerance
Oral:
Very common (10% or more): Sedation (up to 15.9%)
Common (1% to 10%): Anterograde amnesia, ataxia, daytime drowsiness, dizziness, unsteadiness
Rare (0.01% to 0.1%): Dysarthria, headache, memory impairment, reduced alertness, slurred speech, transient anterograde amnesia
Very rare (less than 0.01%): Coma, extrapyramidal reactions, tremor
Frequency not reported: Amnesia, autonomic manifestations, convulsions/seizures, drowsiness, extremity numbness/tingling, hyperreflexia, hypersensitivity to light/noise/sound, involuntary movements, short-term memory loss, vertigo
Parenteral:
Common (1% to 10%): Coma, excessive drowsiness/sleepiness, headache, sedation, somnolence, stupor
Uncommon (0.1% to 1%): Brain edema, convulsion, myoclonus, tremor
Frequency not reported: Dizziness
Postmarketing reports: Amnesia, neuroleptic malignant syndrome, paralysis
Oral:
Common (1% to 10%): Asthenia, fatigue, weakness
Uncommon (0.1% to 1%): Chills
Very rare (less than 0.01%): Hypothermia
Frequency not reported: Hyperacusis, hyperthermia, paradoxical reactions, rebound phenomena
Parenteral:
Common (1% to 10%): Asthenia, crying, fatigue, sobbing
Frequency not reported: Depressed hearing, falls, hypothermia, paradoxical reactions, tinnitus
Postmarketing reports: Fatalities
Oral:
Rare (0.01% to 0.1%): Change in libido, confusion, decreased orgasm, depression, disinhibition, euphoria, numbed emotions, sleep disturbances, unmasking of depression
Frequency not reported: Aggression, aggressiveness, agitation, anxiety, catatonia, dependence, delirium, delusion, disorientation, drug withdrawal symptoms, excitation, hallucinations, hostility, impotence, inappropriate behavior, irritability, insomnia, nightmares, panic attacks, psychoses, rage, restlessness, sexual arousal, suicidal attempt/ideation, tension
Parenteral:
Common (1% to 10%): Confusion, delirium, depression, restlessness, unmasking of depression, visual hallucinations
Uncommon (0.1% to 1%): Abnormal thinking, agitation, ataxia, change in libido, decreased orgasm, hallucinations
Frequency not reported: Aggression, agitation, anxiety, disinhibition, excitation, euphoria, hostility, inappropriate behavior, insomnia, irritability, mania, psychosis, rage, sexual arousal, sleep disturbances, stimulation, suicidal attempt/ideation
Postmarketing reports: Acute brain syndrome, nervousness
Oral:
Rare (0.01% to 0.1%): Apnea, respiratory depression, worsening of obstructive pulmonary disease, worsening of sleep apnea
Parenteral:
Common (1% to 10%): Apnea, hypoventilation, respiratory disorder, respiratory failure
Uncommon (0.1% to 1%): Hyperventilation
Frequency not reported: Airway obstruction
Postmarketing reports: Lung edema, lung hemorrhage, pneumothorax, pulmonary hypertension, respiratory arrest
Oral:
Rare (0.01% to 0.1%): Hypotension
Frequency not reported: Palpitations, small decreases in blood pressure
Parenteral:
Common (1% to 10%): Hypotension
Postmarketing reports: Arrhythmia, bradycardia, heart arrest/failure, heart block, pericardial effusion, tachycardia, ventricular arrhythmia
Oral:
Frequency not reported: Muscle pain
Parenteral:
Common (1% to 10%): Muscle weakness
Oral:
Rare (0.01% to 0.1%): Constipation, nausea, salivation changes
Frequency not reported: Abdominal cramps, dry mouth, gastrointestinal symptoms, hypersalivation, vomiting
Parenteral:
Uncommon (0.1% to 1%): Increased salivation, nausea, vomiting
Frequency not reported: Constipation
Postmarketing reports: Gastrointestinal hemorrhage
Oral:
Rare (0.01% to 0.1%): Change in appetite, increase in alkaline phosphatase
Very rare (less than 0.01%): Hyponatremia
Frequency not reported: Loss of appetite
Parenteral:
Uncommon (0.1% to 1%): Acidosis, increased alkaline phosphatase
Frequency not reported: Hyponatremia
Oral:
Rare (0.01% to 0.1%): Allergic dermatitis, rash
Frequency not reported: Allergic skin reactions, alopecia, dermatological symptoms, sweating
Parenteral:
Uncommon (0.1% to 1%): Hypertension, hypotension
Frequency not reported: Allergic skin reactions, alopecia, skin rash
Oral:
Rare (0.01% to 0.1%): Abnormal liver function test values, increase in bilirubin, increase in liver transaminases, jaundice
Parenteral:
Uncommon (0.1% to 1%): Abnormal liver function tests
Postmarketing reports: Liver damage
Oral:
Rare (0.01% to 0.1%): Impotence
Parenteral:
Uncommon (0.1% to 1%): Impotence
Postmarketing reports: Urinary incontinence
Parenteral:
Uncommon (0.1% to 1%): infection
Parenteral:
Uncommon (0.1% to 1%): Cystitis
Oral:
Rare (0.01% to 0.1%): Blurred vision, diplopia, eye function/visual disturbance
Parenteral:
Frequency not reported: Blurred vision, diplopia
Oral:
Very rare (less than 0.01%): Agranulocytosis, leukopenia, pancytopenia, thrombocytopenia
Parenteral:
Frequency not reported: Agranulocytosis, hypochromic anemia, leukocytosis, pancytopenia, thrombocythemia, thrombocytopenia
Postmarketing reports: Coagulation disorder
Oral:
Very rare (less than 0.01%): Anaphylactoid reactions, anaphylaxis, hypersensitivity
Frequency not reported: Hypersensitivity reactions
Parenteral:
Frequency not reported: Anaphylactic reactions, anaphylactoid reactions, angioedema, hypersensitivity reactions
Oral:
Very rare (less than 0.01%): Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
Parenteral:
Frequency not reported: Syndrome of inappropriate antidiuretic hormone secretion (SIADH)
Postmarketing reports: Aggravation of pheochromocytoma
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Lorazepam Intensol (www.drugs.com/lorazepam.html).
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