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Generic Name: sodium zirconium cyclosilicate ( SOE dee um zir KOE nee um SYE kloe SIL i kate)
Brand Name: Lokelma
Physician reviewed Lokelma patient information - includes Lokelma description, dosage and directions.
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Drug Information:
Lokelma is used to treat hyperkalemia (high levels of Potassium in the blood) in adults. Lokelma works directly in the intestines and is not absorbed into your bloodstream. Lokelma may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare prOviders about all your medical conditions, allergies, and all medicines you use. Tell your doctor if you have ever had: slow digestion; a bowel obstruction or severe constipation; Learn more

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Lokelma Side Effects

Note: This document contains side effect information about sodium zirconium cyclosilicate. Some of the dosage forms listed on this page may not apply to the brand name Lokelma.

For the Consumer

Applies to sodium zirconium cyclosilicate: oral powder for suspension

Along with its needed effects, sodium zirconium cyclosilicate (the active ingredient contained in Lokelma) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sodium zirconium cyclosilicate:

More common

  • Swelling

Less common

  • Decreased urine
  • dry mouth
  • increased thirst
  • irregular heartbeat
  • loss of appetite
  • mood changes
  • muscle pain or cramps
  • nausea
  • numbness or tingling in the hands, feet, or lips
  • seizures
  • unusual tiredness or weakness
  • vomiting

For Healthcare Professionals

Applies to sodium zirconium cyclosilicate: oral powder for reconstitution


The most commonly reported adverse reactions reported during clinical trials included edema and hypokalemia.


Very common (10% or more): Edema (up to 16.1%)

During clinical trials, edema was reported in 4.4% of patients receiving 5 g/day, 5.9% of patients receiving 10 g/day and 16.1% of patients receiving 15 g/day for up to 28 days (placebo 2.4%). In longer-term trials, 8% to 11% of patients receiving doses less than 15 g/day reported edema, generalized edema and peripheral edema.


Common (1% to 10%): Hypokalemia

Frequency not reported: Increase in sodium bicarbonate concentrations

In clinical trials, 4.1% of patients developed hypokalemia which resolved with dose reduction or discontinuation.

Small, dose-dependent increases in sodium bicarbonate occurred with once daily dosing (1.1 mmol/L at 5 g/day; 2.3 mmol/L at 10 g/day; 2.6 mmol/L at 15 g/day; 0.6 mmol/L in placebo). The clinical significance of this is unknown.

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Lokelma (www.drugs.com/mtm/lokelma.html).