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Liothyronine Sodium

Liothyronine sodium Prescription
Generic Name: liothyronine (LYE oh THYE roe neen)
Brand Name: Cytomel, Triostat
Physician reviewed liothyronine patient information - includes liothyronine description, dosage and directions.

Average Savings for liothyronine sodium (brand): 28.19%
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Liothyronine Sodium Drug Information:

Liothyronine is a man-made form of a hormone that is normally produced by your Thyroid gland to regulate the body's energy and metabolism. Liothyronine is given when the Thyroid does not produce enough of this hormone on its own. Liothyronine treats hypoThyroidism (low Thyroid hormone). Liothyronine is also given as part of a medical test for Thyroid disorders. Liothyronine is also used together with surgery and radioactive Iodine therapy in people with Thyroid cancer. Liothyronine should not be used to treat obesity or weight problems. Learn more

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Liothyronine Sodium Side Effects

For the Consumer

Applies to liothyronine: oral tablet

Other dosage forms:

  • intravenous solution

Oral route (Tablet)

Thyroid hormones, including liothyronine sodium, either alone or with other therapeutic agents, should not be used for the treatment of obesity or for weight loss. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects.

Side effects requiring immediate medical attention

Along with its needed effects, liothyronine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking liothyronine:

Incidence not known

  • Anxiety
  • arm, back, or jaw pain
  • blurred or double vision
  • chest pain or discomfort
  • chest tightness or heaviness
  • crying
  • decreased bone mineral density
  • decreased urine output
  • delusions of persecution, mistrust, suspiciousness, or combativeness
  • diarrhea
  • difficulty breathing
  • dilated neck vein
  • dizziness
  • excessive
  • sweating
  • extreme tiredness or weakness
  • eye pain
  • fainting
  • false or unusual sense of well-being
  • fast, pounding, or irregular heartbeat or pulse
  • feeling of discomfort
  • feeling of unreality
  • fever
  • headache
  • heat intolerance
  • impaired fertility
  • increased appetite
  • increased blood pressure
  • irregular breathing
  • irritability
  • itching, skin rash
  • joint swelling
  • limp pain in the hip or knee
  • menstrual changes
  • mental depression
  • muscle aches, weakness, or cramps
  • nausea
  • nervousness
  • pain or discomfort in the arms, jaw, back, or neck
  • quick to react or overreact emotionally
  • rapidly changing moods
  • restlessness
  • sense of detachment from self or body
  • severe headache
  • slow heartbeat
  • stomach cramps
  • swelling of the face, fingers, feet, or lower legs
  • swollen lymph glands
  • tremors
  • trouble sitting still
  • trouble sleeping
  • vomiting
  • weight gain or loss

Get emergency help immediately if any of the following symptoms of overdose occur while taking liothyronine:

Symptoms of overdose

  • Cold, clammy skin
  • confusion about identity, place, and time
  • difficulty in speaking
  • dizziness
  • double vision
  • fast, weak pulse
  • headache
  • inability to move the arms, legs, or facial muscles
  • inability to speak
  • lightheadedness
  • loss of consciousness
  • nervousness
  • seizure
  • sensitivity to heat
  • slow speech
  • sweating
  • trouble sleeping
  • weight loss
Side effects not requiring immediate medical attention

Some side effects of liothyronine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Feeling of warmth
  • hair loss
  • redness of the face, neck, arms, and occasionally, upper chest

For Healthcare Professionals

Applies to liothyronine: compounding powder, intravenous solution, oral tablet


Reported side effects are usually indicative of excessive dosage and will usually disappear when the dose is reduced or treatment is stopped.


Common (1% to 10%): Arrhythmia, tachycardia, cardiopulmonary arrest, hypotension, myocardial infarction

Frequency not reported: Angina, congestive heart failure, hypertension, flushing, palpitation

Nervous system

Frequency not reported: Headache, tremor, benign intracranial hypertension


Frequency not reported: Allergic skin reaction, sweating, rash pruritus, transient hair loss


Frequency not reported: Twitching, muscle cramps, muscle weakness, craniostenosis, premature closure of epiphysis


Frequency not reported: Diarrhea, vomiting


Frequency not reported: Hypersensitivity reaction


Frequency not reported: Phlebitis


Frequency not reported: Restlessness, excitability, insomnia


Frequency not reported: Menstruation irregular


Frequency not reported: Fever, edema, weight loss, heat intolerance

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Liothyronine Sodium (www.drugs.com/mtm/liothyronine.html).