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    Lioresal Intrathecal

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    Lioresal intrathecal Prescription
    Generic Name: Baclofen Intrathecal Injection (BAK loe fen)
    Brand Name: Gablofen, Lioresal
    Easy-to-read patient leaflet for Lioresal. Includes indications, proper use, special instructions, precautions, and possible side effects.

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    Lioresal Intrathecal Drug Information:

    This is not a list of all drugs or health problems that interact with Lioresal (Baclofen intrathecal injection). Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Lioresal (Baclofen intrathecal injection) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Use Lioresal (Baclofen intrathecal injection) as ordered by your doctor. Read all information given to you. Follow all instructions closely. Learn more

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    Lioresal

    Generic Name: Baclofen Intrathecal Injection (BAK loe fen)
    Brand Name: Gablofen, Lioresal
    Uses of Lioresal:
    • It is used to relax muscles.
    • It is used to treat spasms in patients with MS (multiple sclerosis) or spinal cord disease.
    • It may be given to you for other reasons. Talk with the doctor.

    What do I need to tell my doctor BEFORE I take Lioresal?

    • If you have an allergy to baclofen or any other part of Lioresal (baclofen intrathecal injection).
    • If you are allergic to any drugs like this one, any other drugs, foods, or other substances. Tell your doctor about the allergy and what signs you had, like rash; hives; itching; shortness of breath; wheezing; cough; swelling of face, lips, tongue, or throat; or any other signs.
    • If you have an infection.

    This is not a list of all drugs or health problems that interact with Lioresal (baclofen intrathecal injection).

    Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Lioresal (baclofen intrathecal injection) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor.

    What are some things I need to know or do while I take Lioresal?

    • Tell all of your health care providers that you take Lioresal (baclofen intrathecal injection). This includes your doctors, nurses, pharmacists, and dentists.
    • Avoid driving and doing other tasks or actions that call for you to be alert until you see how Lioresal (baclofen intrathecal injection) affects you.
    • Do not stop taking Lioresal (baclofen intrathecal injection) all of a sudden without calling your doctor. You may have a greater risk of side effects. If you need to stop Lioresal (baclofen intrathecal injection), you will want to slowly stop it as ordered by your doctor.
    • Talk with your doctor before you drink alcohol or use other drugs and natural products that slow your actions.
    • Use with care in children. Talk with the doctor.
    • Taking Lioresal (baclofen intrathecal injection) during pregnancy may lead to withdrawal in the newborn.
    • Tell your doctor if you are pregnant, plan on getting pregnant, or are breast-feeding. You will need to talk about the benefits and risks to you and the baby.

    How is this medicine (Lioresal) best taken?

    Use Lioresal (baclofen intrathecal injection) as ordered by your doctor. Read all information given to you. Follow all instructions closely.

    • It is given into the spine.

    What do I do if I miss a dose?

    • Call your doctor to find out what to do.

    What are some side effects that I need to call my doctor about right away?

    WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

    • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
    • Very bad dizziness or passing out.
    • Feeling confused.
    • Change in how often urine is passed.
    • Mental, mood, or behavior changes that are new or worse.
    • Seizures.
    • Change in eyesight.
    • Chest pain.
    • Muscle pain or weakness.
    • Muscle stiffness.
    • A burning, numbness, or tingling feeling that is not normal.
    • Trouble breathing, slow breathing, or shallow breathing.
    • Not able to pass urine or change in how much urine is passed.
    • Blood in the urine.
    • Hallucinations (seeing or hearing things that are not there).
    • Trouble controlling body movements, twitching, change in balance, trouble swallowing or speaking.
    • Not able to control eye movements.
    • A heartbeat that does not feel normal.

    What are some other side effects of Lioresal?

    All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

    • Feeling dizzy, sleepy, tired, or weak.
    • Trouble sleeping.
    • Upset stomach.
    • Headache.
    • Constipation.

    These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

    You may report side effects to the FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch.

    If OVERDOSE is suspected:

    If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.

    How do I store and/or throw out Lioresal?

    • If you need to store Lioresal (baclofen intrathecal injection) at home, talk with your doctor, nurse, or pharmacist about how to store it.
    • Keep all drugs in a safe place. Keep all drugs out of the reach of children and pets.
    • Throw away unused or expired drugs. Do not flush down a toilet or pour down a drain unless you are told to do so. Check with your pharmacist if you have questions about the best way to throw out drugs. There may be drug take-back programs in your area.

    Consumer information use

    • If your symptoms or health problems do not get better or if they become worse, call your doctor.
    • Do not share your drugs with others and do not take anyone else's drugs.
    • Keep a list of all your drugs (prescription, natural products, vitamins, OTC) with you. Give this list to your doctor.
    • Talk with the doctor before starting any new drug, including prescription or OTC, natural products, or vitamins.
    • Some drugs may have another patient information leaflet. Check with your pharmacist. If you have any questions about Lioresal (baclofen intrathecal injection), please talk with your doctor, nurse, pharmacist, or other health care provider.
    • If you think there has been an overdose, call your poison control center or get medical care right away. Be ready to tell or show what was taken, how much, and when it happened.
    Further information

    Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

    Medical Disclaimer

    More about Lioresal (baclofen)

    • Side Effects
    • During Pregnancy or Breastfeeding
    • Dosage Information
    • Drug Images
    • Drug Interactions
    • 1 Review
    • Generic Availability
    • Drug class: skeletal muscle relaxants
    • FDA Alerts (3)

    Consumer resources

    Other brands: Gablofen, Ozobax

    Professional resources

    • ... +1 more

    Other Formulations

    • Lioresal Intrathecal

    Related treatment guides

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    Editorial References and Review

    Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

    Source: Drugs.com Lioresal Intrathecal (www.drugs.com/lioresal.html).

    Lioresal Intrathecal Side Effects

    Note: This document contains side effect information about baclofen. Some of the dosage forms listed on this page may not apply to the brand name Lioresal.

    For the Consumer

    Applies to baclofen: oral powder for suspension, oral tablet

    Other dosage forms:

    • intrathecal solution

    Along with its needed effects, baclofen (the active ingredient contained in Lioresal) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

    Check with your doctor as soon as possible if any of the following side effects occur while taking baclofen:

    Less common or rare

    • Bloody or dark urine
    • chest pain
    • fainting
    • hallucinations (seeing or hearing things that are not there)
    • mental depression or other mood changes
    • ringing or buzzing in the ears
    • skin rash or itching

    Symptoms of overdose

    • Blurred or double vision
    • convulsions (seizures)
    • muscle weakness (severe)
    • shortness of breath or unusually slow or troubled breathing
    • vomiting

    Some side effects of baclofen may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

    More common

    • Confusion
    • dizziness or lightheadedness
    • drowsiness
    • nausea
    • unusual weakness, especially muscle weakness

    Less common or rare

    • Abdominal or stomach pain or discomfort
    • clumsiness, unsteadiness, trembling, or other problems with muscle control
    • constipation
    • diarrhea
    • difficult or painful urination or decrease in amount of urine
    • false sense of well-being
    • frequent urge to urinate or uncontrolled urination
    • headache
    • loss of appetite
    • low blood pressure
    • muscle or joint pain
    • numbness or tingling in hands or feet
    • pounding heartbeat
    • sexual problems in males
    • slurred speech or other speech problems
    • stuffy nose
    • swelling of ankles
    • trouble in sleeping
    • unexplained muscle stiffness
    • unusual excitement
    • unusual tiredness
    • weight gain

    After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

    • Convulsions (seizures)
    • hallucinations (seeing or hearing things that are not there)
    • increase in muscle spasm, cramping, or tightness
    • mood or mental changes
    • unusual nervousness or restlessness

    For Healthcare Professionals

    Applies to baclofen: compounding powder, intrathecal solution, oral suspension, oral tablet

    Cardiovascular

    Common (1% to 10%): Cardiac output decreased, hypotension, hypertension, diminished cardiovascular functions, peripheral edema

    Rare (less than 0.1%): Arrhythmias, palpitations, chest pain

    Frequency not reported: Bradycardia, orthostatic hypotension

    Dermatologic

    Common (1% to 10%): Rash, hyperhidrosis, urticaria/pruritus, facial edema

    Uncommon (0.1% to 1%): Alopecia, diaphoresis

    Frequency not reported: Rash, sweating, contact dermatitis, skin ulcer

    Endocrine

    Common (1% to 10%): Ovarian cysts are palpable in 4% of women treated with for up to one year

    Gastrointestinal

    Very common (10% or more): Nausea (especially at start of therapy) (up to 11%)

    Common (1% to 10%): Dry mouth, GI disorder/disturbance, constipation, diarrhea, retching, vomiting, increased salivation

    Uncommon (0.1% to 1%): Dysphagia, dehydration, ileus, decreased taste sensation

    Rare (less than 0.1%): Colicky abdominal pain, anorexia

    Frequency not reported: GI hemorrhage

    Genitourinary

    Very common (10% or more): Urinary retention (up to 12%)

    Common (1% to 10%): Urinary incontinence, urination impaired, sexual dysfunction, urinary frequency, enuresis, dysuria

    Rare (less than 0.1%): Erectile dysfunction

    Frequency not reported: Dysuria, abnormal ejaculation, oliguria, vaginitis

    Hematologic

    Frequency not reported: Leukocytosis, petechial rash

    Hepatic

    Rare (less than 0.1%): Disorders of hepatic function (e.g., increased AST)

    Immunologic

    Common (1% to 10%): Pneumonia

    Uncommon (0.1% to 1%): Septicemia

    Metabolic

    Common (1% to 10%): Decreased appetite

    Frequency not reported: Blood glucose increased

    Musculoskeletal

    Very common (10% or more): Hypotonia (up to 52%), lower extremity weakness (up to 15%), disturbances of gait and balance

    Common (1% to 10%): Muscular weakness, myalgia, upper extremity weakness, back pain, muscular hypertonia

    Nervous system

    Very common (10% or more): Somnolence (up to 28%), drowsiness (up to 18%), headache (up to 16%), seizures (especially on discontinuation of therapy) (up to 15%), sedation, dizziness (up to 12%)

    Common (1% to 10%): Fatigue, ataxia, tremor, lightheadedness, lassitude, exhaustion, numbness/itching/tingling, slurred speech, lethargy, hypertonia, paresthesia

    Rare (less than 0.1%): Dysarthria, dysgeusia, syncope, dyskinesia, coma, potentially life-threatening withdrawal symptoms (as a result of sudden interruption of drug delivery)

    Other

    Common (1% to 10%): Tinnitus, pain, asthenia

    Uncommon (0.1% to 1%): Accidental injury, weight loss

    Very rare (less than 0.01%): Hypothermia

    Frequency not reported: Drug withdrawal syndrome

    Uncommon (0.1% to 1%): Subdural hemorrhage, accidental injury, weight loss

    Ocular

    Common (1% to 10%): Nystagmus, visual impairment, accommodation disorder, blurred vision, double vision, amblyopia

    Psychiatric

    Common (1% to 10%): Confusional state, hallucination, depression, insomnia, euphoric mood, nightmare, personality changes

    Uncommon (0.1% to 1%): Memory loss/impairment, suicidal ideation, attempted suicide

    Rare (less than 0.1%): Excitement

    Renal

    Very rare (less than 0.01%): Kidney calculus

    Respiratory

    Common (1% to 10%): Respiratory depression, hypoventilation, dyspnea, bradypnea, feeling of pressure in the chest

    Editorial References and Review

    Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

    Source: Drugs.com Lioresal Intrathecal (www.drugs.com/lioresal.html).

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