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Note: This document contains side effect information about levothyroxine. Some of the dosage forms listed on this page may not apply to the brand name Levoxyl.For the Consumer
Applies to levothyroxine: oral capsule liquid filled, oral tablet
Other dosage forms:
Oral route (Capsule; Tablet; Solution)
Thyroid hormones, including levothyroxine, should not be used either alone or with other therapeutic agents for the treatment of obesity or weight loss. In euthyroid patients, doses within the range of daily hormonal requirements are ineffective for weight reduction. Larger doses may produce serious or even life-threatening manifestations of toxicity, particularly when given in association with sympathomimetic amines such as those used for their anorectic effects.
Along with its needed effects, levothyroxine (the active ingredient contained in Levoxyl) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking levothyroxine:
Get emergency help immediately if any of the following symptoms of overdose occur while taking levothyroxine:
Symptoms of overdose
Some side effects of levothyroxine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
For Healthcare Professionals
Applies to levothyroxine: compounding powder, injectable powder for injection, intravenous powder for injection, intravenous solution, oral capsule, oral solution, oral tabletGeneral
The more commonly reported adverse events have included those of hyperthyroidism due to therapeutic overdose including arrhythmias, myocardial infarction, dyspnea, muscle spasm, headache, nervousness, irritability, insomnia, tremors, muscle weakness, increased appetite, weight loss, diarrhea, heat intolerance, menstrual irregularities, and skin rash.Cardiovascular
Cardiac function was evaluated in 20 patients requiring TSH suppression for either thyroid goiter or following thyroidectomy and radioactive iodine therapy for thyroid cancer and in 20 age and sex-matched controls. TSH suppression was associated with an increased incidence of premature ventricular beats, an increased left ventricular mass index, and enhanced left ventricular systolic function. The clinical significance of these changes remains to be determined.
Overtreatment with this drug may cause an increase in heart rate, cardiac wall thickness, and cardiac contractility and may precipitate angina or arrhythmias, particularly in patients with cardiovascular disease and in elderly patients.
Frequency not reported: Palpitations, tachycardia, hypertension, arrhythmias, increased pulse and blood pressure, heart failure, angina, myocardial infarction, cardiac arrestEndocrine
Frequency not reported: Changes in symptom presentation for diabetes and adrenal cortical insufficiencyNervous system
Frequency not reported: Headache, hyperactivity, insomnia, seizures, pseudotumor cerebri (children)Dermatologic
Frequency not reported: Hair loss, flushing, urticaria, pruritus, skin rash, angioedema, excessive sweatingMusculoskeletal
A study evaluated the effect of long-term thyroid hormone therapy on bone mineral density in 196 women (mean age, 74.4 years) compared to a control group comprised of 795 women (mean age, 72.1 years). The mean daily thyroxine dose was 1.99 mcg/kg (range, 0.3 to 6.6 mcg/kg) with a mean duration of therapy of 20.4 years (range, less than 1 to 68 years). Women taking daily doses of 1.6 mcg/kg or more had significantly lower bone mineral density levels at the ultradistal radius, midshaft radius, hip, and lumbar spine compared to controls. However, estrogen use appeared to negate the adverse effects of thyroid hormone on bone mineral density.
Higher rates of femur fractures have been found in males (p=0.008) prescribed long-term thyroid hormone therapy as compared to controls in a case-control analysis of 23,183 patients, from the United Kingdom General Practice Research Database, prescribed thyroid hormone.
Overtreatment may result in craniosynostosis in infants and premature closure of the epiphyses in children with resultant compromised adult height.
Frequency not reported: Tremors, muscle weakness, muscle cramps, increased risk of osteoporosis, slipped capital femoral epiphysis (children)Gastrointestinal
Frequency not reported: Diarrhea, vomiting, abdominal crampsGenitourinary
Frequency not reported: Menstrual irregularities, impaired fertilityHypersensitivity
Hypersensitivity reactions have occurred; however, it has been attributed to the inactive ingredients. These reactions have included urticaria, pruritus, skin rash, flushing, angioedema, various GI symptoms (abdominal pain, nausea, vomiting and diarrhea), fever, arthralgia, serum sickness and wheezing. Hypersensitivity to levothyroxine (the active ingredient contained in Levoxyl) itself is not known to occur.
Frequency not reported: Serum sickness, hypersensitivity to inactive ingredientsMetabolic
Frequency not reported: Increased appetite, weight lossImmunologic
Frequency not reported: Autoimmune disorders (e.g., chronic autoimmune thyroiditis)Other
Frequency not reported: Fatigue, heat intolerance, feverPsychiatric
Frequency not reported: Nervousness, anxiety, irritability, emotional lability
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