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Levoleucovorin Calcium

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Levoleucovorin calcium Prescription
Generic Name: Levoleucovorin (LEE voe LOO koe voe rin)
Brand Names: Fusilev, Khapzory
Levoleucovorin (Fusilev) is used to treat toxic effects of methotrexate in people who have received methotrexate to treat bone cancer. Includes levoleucovorin side effects, interactions and indications.
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Levoleucovorin Calcium Drug Information:

Levoleucovorin (Fusilev) is used to treat or prevent toxic effects of Methotrexate in people who have received Methotrexate to treat bone cancer. Levoleucovorin is also used to treat or prevent toxic effects of Methotrexate in people whose bodies do not eliminate Methotrexate properly after the drug is metabolized. It may also be used to treat toxic effects of an overdose of Methotrexate or certain other medications. Levoleucovorin is also used in combination chemotherapy with Fluorouracil to treat colorectal cancer that has spread to other parts of the body. Levoleucovorin treats only the symptoms of colorectal cancer but does not treat the cancer itself. Learn more

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Levoleucovorin Calcium Side Effects

In Summary

More frequently reported side effects include: diarrhea. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to Levoleucovorin: intravenous powder for solution, intravenous solution

Along with its needed effects, Levoleucovorin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking Levoleucovorin:

More common

  • Cloudy urine
  • decrease in urine output or decrease in urine-concentrating ability
  • difficult or labored breathing
  • fever
  • general feeling of discomfort or illness
  • lack or loss of strength
  • shortness of breath
  • stomach cramps, tenderness, or pain
  • tightness in the chest
  • unusual tiredness or weakness
  • watery or bloody diarrhea
  • wheezing

Incidence not known

  • Feeling unusually cold
  • shivering

Some side effects of Levoleucovorin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Acid or sour stomach
  • bad, unusual, or unpleasant (after) taste
  • belching
  • blistering, crusting, irritation, itching, reddening, or swelling of the skin
  • burning, tingling, numbness, or pain in the hands, arms, feet, or legs
  • change in taste
  • cracked, dry, or scaly skin
  • decreased appetite
  • diarrhea
  • hair loss or thinning of the hair
  • heartburn
  • indigestion
  • loss of appetite
  • mood or mental changes
  • nausea
  • sensation of pins and needles
  • stabbing pain
  • stomach discomfort or upset
  • swelling or inflammation of the mouth
  • vomiting
  • weight loss

Incidence not known

  • Rash

For Healthcare Professionals

Applies to Levoleucovorin: intravenous powder for injection, intravenous solution


Very common (10% or more): Stomatitis (37.5%), vomiting (37.5%), nausea (18.8%)

Common (1% to 10%): Diarrhea, dyspepsia, typhlitis


Common (1% to 10%): Dyspnea


Common (1% to 10%): Dermatitis

Postmarketing reports: Pruritus, rash


Postmarketing reports: Temperature change, rigors

Nervous system

Common (1% to 10%): Neuropathy, taste perversion


Common (1% to 10%): Renal function abnormal


Postmarketing reports: Possible allergic reactions


Frequency not reported: Leukopenia, thrombocytopenia


Common (1% to 10%): Confusion

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Levoleucovorin Calcium (www.drugs.com/levoleucovorin.html).