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Leucovorin Calcium

Leucovorin calcium Prescription
Generic Name: leucovorin (oral) (LOO koe VOR in)
Brand Name:
Physician reviewed leucovorin (oral) patient information - includes leucovorin description, dosage and directions.

Average Savings for leucovorin calcium (generic): 28.29%
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Leucovorin Calcium Drug Information:

Leucovorin is a form of Folic Acid. Folic Acid helps your body produce and maintain new cells, and also helps prevent changes to DNA that may lead to cancer. Folic Acid is present in many foods such as dried beans, peas, oranges, spinach, and others. Leucovorin is used to reduce the side effects of large doses or accidental overdose of medications that can reduce the effects of Folic Acid in the body. This includes Methotrexate (Rheumatrex), Pyrimethamine (DarAprim), Trimethoprim (Trimpex, Proloprim), and others. Learn more

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Leucovorin Calcium Side Effects

For the Consumer

Applies to leucovorin: powder for solution, solution, tablet

Side effects requiring immediate medical attention

Along with its needed effects, leucovorin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking leucovorin:


  • Skin rash, hives, or itching
  • wheezing

Check with your doctor as soon as possible if any of the following side effects occur while taking leucovorin:


- reported with use in treatment of cancer
  • Convulsions (seizures)

For Healthcare Professionals

Applies to leucovorin: compounding powder, injectable powder for injection, injectable solution, oral tablet


Adverse events attributed to use of leucovorin/folinic acid by itself include allergic sensitization, including anaphylactoid reactions and urticaria; gastrointestinal and hematologic adverse events were common when used with fluorouracil.


Very common (10% or more): Stomatitis (75%, when used with fluorouracil), nausea (74%, when used with fluorouracil), diarrhea (66%, when used with fluorouracil), vomiting (46%, when used with fluorouracil), dehydration (when used with fluorouracil)

Common (1% to 10%): Constipation (when used with fluorouracil)

Rare (less than 0.1%): Gastrointestinal disorders (after high doses)

Frequency not reported: Mucositis (when used with fluorouracil), cheilitis (when used with fluorouracil)

When used with fluorouracil, diarrhea and dehydration have resulted in hospital admission and death.


Very common (10% or more): Leucopenia (69%, when used with fluorouracil)

Common (1% to 10%): Thrombocytopenia (when used with fluorouracil)


Very rare (less than 0.01%): Allergic reactions (sensitization, including anaphylactoid reactions, shock, and urticaria)

Frequency not reported: Stevens Johnson Syndrome and Toxic Epidermal Necrolysis (in combination with other agents)


Very common (10% or more): Alopecia (42%, when used with fluorouracil), dermatitis (21%, when used with fluorouracil)

Frequency not reported: Palmar-plantar erythrodysesthesia (when used with fluorouracil)


Very common (10% or more): Lethargy/malaise/fatigue (13%, when used with fluorouracil)

Uncommon (0.1% to 1%): Pyrexial reactions (following parenteral administration)


Very common (10% or more): Anorexia (14%, when used with fluorouracil)

Frequency not reported: Hyperammonemia (when used with fluorouracil)


Common (1% to 10%): Infection (when used with fluorouracil)

Nervous system

Rare (less than 0.1%): Increase in the frequency of attacks in epileptics, seizures, syncope


Rare (less than 0.1%): Insomnia, agitation, depression

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Leucovorin Calcium (www.drugs.com/mtm/leucovorin.html).