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Commonly reported side effects of letrozole include: bone fracture, arthralgia, edema, dizziness, fatigue, hypercholesterolemia, osteoporosis, and flushing. Other side effects include: myalgia. See below for a comprehensive list of adverse effects.
For the ConsumerApplies to letrozole: oral tablet
Along with its needed effects, letrozole may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking letrozole:
Less common
Rare
Incidence not known
Some side effects of letrozole may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Incidence not known
For Healthcare Professionals
Applies to letrozole: oral tablet
CardiovascularVery common (10% or more): Hot flash/flushing (50%), cardiovascular disease (14%), other cardiovascular event (13%)
Common (1% to 10%): Hypertension, chest pain, cardiac event (angina, coronary heart disease, myocardial ischemia, myocardial infarction), cardiac failure
Uncommon (0.1% to 1%): Palpitation, tachycardia, arterial thrombosis
GastrointestinalVery common (10% or more): Nausea (17%), constipation (11%)
Common (1% to 10%): Vomiting, diarrhea, abdominal pain, dyspepsia
Uncommon (0.1% to 1%): Stomatitis, dry mouth
OtherVery common (10% or more): Fatigue/lethargy/malaise/asthenia (34%), edema (18%), night sweats (15%)
Common (1% to 10%): Influenza, peripheral edema, pain, post-mastectomy lymphedema, thromboembolic event, viral infection
Uncommon (0.1% to 1%): Pyrexia, mucosal dryness, thirst
Frequency not reported: Peripheral thromboembolic event (venous thrombosis, thrombophlebitis, portal vein thrombosis, pulmonary embolism)
MusculoskeletalVery common (10% or more): Arthralgia/arthritis (25%), bone fracture (22%), musculoskeletal pain/back pain/arm pain/leg pain (22%), osteoporosis (15%), extremity/limb pain (10%)
Common (1% to 10%): Myalgia, bone pain, osteopenia, decreased lumbar spine bone mineral density
Postmarketing reports: Trigger finger
Nervous systemVery common (10% or more): Headache (20%), dizziness/lightheadedness (14%)
Common (1% to 10%): Somnolence, cerebrovascular events (transient ischemic attack, thrombotic or hemorrhagic stroke, hemiparesis development)
Uncommon (0.1% to 1%): Memory impairment, dysesthesia (hypesthesia/paresthesia), taste and thirst disturbance, carpal tunnel syndrome
Rare (less than 0.1%): Cerebrovascular infarction
Frequency not reported: Vertigo
RespiratoryVery common (10% or more): Dyspnea (18%), cough (13%)
Common (1% to 10%): Chest wall pain
Frequency not reported: Pleural effusion
DermatologicVery common (10% or more): Increased sweating (24%)
Common (1% to 10%): Alopecia, dry skin, rash (erythematous, maculopapular, psoriasiform, vesicular), pruritus
Uncommon (0.1% to 1%): Urticaria
Very rare (less than 0.01%): Angioedema, toxic epidermal necrolysis, erythema multiforme
HepaticUncommon (0.1% to 1%): Increased hepatic enzymes
Very rare (less than 0.01%): Hepatitis
HematologicUncommon (0.1% to 1%): Leukopenia
Frequency not reported: Decreased lymphocyte count, thrombocytopenia
OcularCommon (1% to 10%): Cataract
Uncommon (0.1% to 1%): Eye irritation, blurred vision
MetabolicVery common (10% or more): Hypercholesterolemia (53%), increased weight (13%)
Common (1% to 10%): Decreased weight, anorexia, increased appetite
Frequency not reported: Hypercalcemia
GenitourinaryVery common (10% or more): Vaginal bleeding (13%)
Common (1% to 10%): Vaginal irritation, vaginal hemorrhage, vulvovaginal dryness, breast pain, urinary tract infection
Uncommon (0.1% to 1%): Increased urinary frequency, vaginal discharge
HypersensitivityVery rare (less than 0.01%): Anaphylactic reactions
OncologicCommon (1% to 10%): Secondary malignancy
Uncommon (0.1% to 1%): Endometrial hyperplasia/cancer, endometrial proliferation disorder, tumor pain
Rare (less than 0.1%): Other endometrial disorder
Frequency not reported: Stomatitis cancer pain
PsychiatricCommon (1% to 10%): Depression, insomnia
Uncommon (0.1% to 1%): Anxiety, nervousness, irritability
RenalCommon (1% to 10%): Renal disorders
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Letrozole (www.drugs.com/mtm/letrozole.html).
May 17, 2022
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