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Latuda (lurasidone) is an antipsychotic medicine. It works by changing the effects of chemicals in the brain.
Latuda is used to treat schizophrenia in adults and teenagers who are at least 13 years old.
Latuda is also used to treat episodes of depression associated with bipolar disorder (bipolar depression) in adults and children who are at least 10 years old.
Latuda is not approved for use in psychotic conditions related to dementia. Lurasidone may increase the risk of death in older adults with dementia-related conditions.
Some young people have thoughts about suicide when first taking medicine to treat depression. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor.
Before you take Latuda, tell your doctor if you have liver disease, kidney disease, heart disease, high blood pressure, heart rhythm problems, a history of heart attack or stroke, high cholesterol or triglycerides, low white blood cell (WBC) counts, seizures, diabetes, Parkinson's disease, trouble swallowing, or a history of breast cancer or suicidal thoughts.
Some medicines can interact with lurasidone and should not be used at the same time. Tell each of your healthcare providers about all medicines you use now, and any medicine you start or stop using.
While you are taking Latuda, you may be more sensitive to temperature extremes such as very hot or cold conditions. Avoid getting too cold, or becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking this medicine.
Latuda may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Get up slowly and steady yourself to prevent a fall.
Drinking alcohol can increase certain side effects of lurasidone. Stop using this medicine and call your doctor at once if you have very stiff (rigid) muscles, high fever, sweating, confusion, fast or pounding heartbeats, feeling like you might pass out, tremors, or twitching or uncontrollable movements of your eyes, lips, tongue, face, arms, or legs.
You should not use Latuda if you are allergic to lurasidone.
Some medicines can interact with lurasidone and should not be used at the same time. Your doctor may need to change your treatment plan if you use certain other medicines, including:
antifungal medicine such as ketoconazole or voriconazole;
an antibiotic such as clarithromycin or rifampin;
an antiviral such as ritonavir;
St. John's wort; or
seizure medicine such as carbamazepine or phenytoin.
Latuda is not approved for use in psychotic conditions related to dementia. Lurasidone may increase the risk of death in older adults with dementia-related conditions.
Tell your doctor if you have ever had:
heart disease or a stroke;
high or low blood pressure;
high cholesterol or triglycerides (a type of fat in the blood);
diabetes or high blood sugar (in you or your family);
a seizure;
liver or kidney disease;
low white blood cell (WBC) counts;
abnormal hormone function tests (thyroid, pituitary gland);
breast cancer; or
suicidal thoughts or actions.
Some young people have thoughts about suicide when first taking medicine to treat depression. Your doctor should check your progress at regular visits. Your family or other caregivers should also be alert to changes in your mood or symptoms.
Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking lurasidone, do not stop taking it without your doctor's advice.
Your name may be listed on a pregnancy registry. This is to track the outcome of the pregnancy and to evaluate any effects of Latuda on the baby.
It may not be safe to breast-feed a baby while you are using this medicine. Ask your doctor about any risks.
Latuda is not approved for schizophrenia in anyone younger than 13 years old. Latuda is not approved for depression in anyone younger than 10 years old.
Take Latuda exactly as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets.
Latuda should be taken with food (at least 350 calories).
You may need frequent blood tests.
It may take several weeks before your symptoms improve. Keep using the medication as directed. Call your doctor if your symptoms do not improve, or if they get worse while using Latuda.
You should not stop using this medicine suddenly. Stopping suddenly may cause other problems.
Store at room temperature away from moisture and heat.
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Get your prescription refilled before you run out of medicine completely.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Avoid drinking alcohol. Dangerous side effects could occur.
Avoid driving or operating machinery until you know how this medicine will affect you. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Dizziness or drowsiness can cause falls, accidents, or severe injuries.
Grapefruit and grapefruit juice may interact with lurasidone and lead to unwanted side effects. Avoid the use of grapefruit products while taking Latuda.
It is easier to become dangerously overheated and dehydrated while you are taking Latuda. Drink plenty of fluids, especially in hot weather and during exercise. You may also be more sensitive to temperature extremes (hot or cold).
Get emergency medical help if you have signs of an allergic reaction to Latuda: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Report any new or worsening symptoms to your doctor, such as: mood or behavior changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.
High doses or long-term use of Latuda can cause a serious movement disorder that may not be reversible. Symptoms of this disorder include uncontrollable muscle movements of your lips, tongue, eyes, face, arms, or legs. The longer you take lurasidone, the more likely you are to develop a serious movement disorder. The risk of this side effect is higher in diabetics and older adults (especially women).
Call your doctor at once if you have:
any new or unusual muscle movements you cannot control;
a light-headed feeling, like you might pass out;
a seizure (convulsions);
(in women) irregular menstrual periods, breast or vaginal changes, nipple discharge;
(in men) breast swelling, impotence;
trouble swallowing;
low blood cell counts - sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, swollen gums, pain when swallowing, skin sores, cold or flu symptoms, cough, trouble breathing;
high blood sugar - increased thirst, increased urination, hunger, dry mouth, fruity breath odor; or
severe nervous system reaction - very stiff (rigid) muscles, high fever, sweating, confusion, fast or uneven heartbeats, tremors, feeling like you might pass out.
Common Latuda side effects may include:
drowsiness;
weight gain;
tremors, muscle stiffness, problems with muscle movement;
feeling restless or being unable to sit still;
nausea, vomiting;
runny nose; or
sleep problems (insomnia).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Using Latuda with other drugs that slow your breathing can cause dangerous side effects or death. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.
Tell your doctor about all your current medicines. Many drugs can interact with lurasidone, especially:
depression or psychotic episodes;
sleep problems (insomnia);
high blood pressure or a heart rhythm disorder;
swelling or inflammation;
seizures; or
Parkinson's disease.
This list is not complete and many other drugs may interact with lurasidone. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Further informationRemember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Latuda only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.
Source: Drugs.com Latuda (www.drugs.com/latuda.html).
Note: This document contains side effect information about lurasidone. Some of the dosage forms listed on this page may not apply to the brand name Latuda.
In SummaryCommon side effects of Latuda include: psychomotor impairment, akathisia, basal ganglia disease, bradykinesia, cogwheel rigidity, drowsiness, hypokinesia, muscle rigidity, nausea, parkinson's disease, sedated state, tremor, altered serum glucose, and drooling. Other side effects include: oculogyric crisis, trismus, agitation, anxiety, dystonia, torticollis, increased serum prolactin, and weight gain. See below for a comprehensive list of adverse effects.
For the ConsumerApplies to lurasidone: oral tablet
Oral route (Tablet)
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death. Lurasidone is not approved for the treatment of patients with dementia-related psychosis. An increased risk of suicidal thoughts and behavior was found in pediatric and young adult patients taking antidepressants. Monitor for clinical worsening and emergence of suicidal thoughts and behaviors.
Along with its needed effects, lurasidone (the active ingredient contained in Latuda) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking lurasidone:
More common
Less common
Rare
Incidence not known
Some side effects of lurasidone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Rare
For Healthcare Professionals
Applies to lurasidone: oral tablet
GeneralThe most commonly reported adverse events included somnolence, akathisia, extrapyramidal symptoms, and nausea.
MetabolicCommon (1% to 10%): Decreased appetite, increased appetite, increased weight
Uncommon (0.1% to 1%): Hyponatremia, increase in blood sugar levels/blood glucose increased
In uncontrolled, long-term schizophrenia trials, this drug was associated with a mean increase in glucose from baseline of 1.8 mg/dL at 24 weeks, 0.8 mg/dL at 36 weeks, and 2.3 mg/dL at 52 weeks. Similar results were observed in bipolar depression studies. The proportion of patients with a 7% or greater increase in body weight was 4.8% (compared with 3.3% for placebo). Pooled data from short-term trials showed a mean weight gain of 0.43 kg in treated patients (compared with -0.2 kg in placebo).
GastrointestinalVery common (10% or more): Nausea (up to 17.4%), dyspepsia (up to 11%)
Common (1% to 10%): Abdominal pain, diarrhea, dry mouth, salivary hypersecretion, stomach discomfort, upper abdominal pain, vomiting
Uncommon (0.1% to 1%): Dysphagia, flatulence, gastritis
Frequency not reported: Difficulty swallowing, tongue protrusion, tongue spasm, tongue swelling
Nervous systemAkathisia and extrapyramidal symptoms were dose-related.
Very common (10% or more): Somnolence (up to 26%), akathisia (up to 22%), extrapyramidal disorder/symptoms (up to 22%), parkinsonism (up to 17%)
Common (1% to 10%): Dizziness, dyskinesia, dystonia/acute dystonia, tardive dyskinesia
Uncommon (0.1% to 1%): Cerebrovascular accident/adverse reactions, dysarthria, gait disturbance, lethargy, syncope, vertigo
Rare (less than 0.1%): Neuroleptic malignant syndrome, seizure
Frequency not reported: Abnormal glabellar reflex, bradykinesia, cogwheel rigidity, convulsion, drooling, hyperkinesia, hypersomnia, hypersomnolence, hypokinesia, motor impairment, oromandibular dystonia, sedation, stroke, tremor
PsychiatricVery common (10% or more): Insomnia (up to 11%)
Common (1% to 10%): Abnormal dreams, agitation, anxiety, psychomotor hyperactivity, restlessness
Uncommon (0.1% to 1%): Activation of mania/hypomania, catatonia, nightmare, panic attack, sleep disorder
Rare (less than 0.1%): Suicidal behavior/ideation
Frequency not reported: Cognitive impairment, psychomotor retardation
HematologicUncommon (0.1% to 1%): Anemia
Rare (less than 0.1%): Eosinophilia
Frequency not reported: Agranulocytosis, leukopenia, neutropenia
CardiovascularCommon (1% to 10%): Hypertension, tachycardia
Uncommon (0.1% to 1%): Angina pectoris, atrioventricular (AV) block first degree, bradycardia, hot flush, hypotension, increased blood pressure, orthostatic hypotension
Frequency not reported: Deep vein thrombosis, venous thromboembolism
MusculoskeletalCommon (1% to 10%): Back pain, increased blood creatinine phosphokinase, musculoskeletal stiffness
Uncommon (0.1% to 1%): Joint stiffness, myalgia, neck pain
Rare (less than 0.1%): Rhabdomyolysis
Frequency not reported: Muscle rigidity, muscle spasms, neck muscle spasm, torticollis, trismus
DermatologicCommon (1% to 10%): Rash, pruritus
Uncommon (0.1% to 1%): Hyperhidrosis
Frequency not reported: , Stevens-Johnson syndrome, urticaria
Postmarketing reports: Bullous dermatitis, maculopapular rash, pustular rash, severe cutaneous reactions, skin eruption, skin exfoliation
GenitourinaryCommon (1% to 10%): Urinary tract infection
Uncommon (0.1% to 1%): Amenorrhea, dysmenorrhea, dysuria, erectile dysfunction
Rare (less than 0.1%): Breast enlargement, breast pain, galactorrhea
RenalCommon (1% to 10%): Elevated serum creatinine/increased creatinine phosphokinase
Rare (less than 0.1%): Renal failure
EndocrineUncommon (0.1% to 1%): Elevated prolactin levels/blood prolactin increased
Frequency not reported: Hyperprolactinemia
HepaticUncommon (0.1% to 1%): Alanine aminotransferase increased
HypersensitivityCommon (1% to 10%): Hypersensitivity
Rare (less than 0.1%): Angioedema
Frequency not reported: Allergic rhinitis
ImmunologicVery common (10% or more): Viral infection (up to 11%)
Common (1% to 10%): Influenza
OcularCommon (1% to 10%): Blurred vision
Frequency not reported: Oculogyric crisis
OtherCommon (1% to 10%): Fatigue
Rare (less than 0.1%): Sudden death
Frequency not reported: Body temperature dysregulation, falls, neonatal drug withdrawal syndrome
RespiratoryCommon (1% to 10%): Nasopharyngitis, oropharyngeal pain, rhinitis
Frequency not reported: Difficulty breathing, nasal congestion, rhinorrhea, pulmonary embolism, throat tightness, upper respiratory tract infection
Postmarketing reports: Dyspnea, throat swelling
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.
Source: Drugs.com Latuda (www.drugs.com/latuda.html).
July 13, 2020
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February 15, 2021
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February 1, 2021
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