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Lanthanum carbonate is used to lower phosphate levels in patients with end stage kidney disease. High levels of phosphate can make it hard for your body to absorb calcium, which can cause serious medical problems.
Lanthanum carbonate may also be used for purposes not listed in this medication guide.
You should not use lanthanum carbonate if you have a bowel obstruction or severe constipation.
lanthanum carbonate may cause severe bowel obstruction or a perforation (a hole or tear) in your intestines. Your risk is higher if you have ever had stomach or intestinal problems including ulcers, cancer, surgery, or a bowel obstruction.
Call your doctor at once if you have severe stomach pain or tenderness, fever, chills, nausea, vomiting, loss of appetite, severe constipation, or blood in your stools.
You should not use lanthanum carbonate if you are allergic to it, or if you have:
a bowel obstruction or severe constipation.
This medicine may cause severe bowel obstruction or a perforation (a hole or tear) in your intestines, especially if you have ever had stomach or intestinal problems.
Tell your doctor if you have ever had:
a stomach ulcer;
a bowel obstruction;
slow digestion or severe constipation;
surgery on your stomach or intestines;
ulcerative colitis, Crohn's disease, diverticulitis;
stomach or intestinal cancer; or
peritonitis (infection or inflammation of the stomach or intestines).
If you need to have any type of x-ray of your stomach area, tell the doctor ahead of time that you are using lanthanum carbonate.
Tell your doctor if you are pregnant or breast-feeding.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Take lanthanum carbonate with food or immediately after eating.
The chewable tablet must be chewed completely before you swallow it. Do not swallow a chewable tablet whole. Not chewing the tablet completely may lead to serious stomach or intestinal problems.
If you have tooth problems or cannot chew easily, crush the chewable tablet before swallowing, or ask your doctor about using the oral powder form of lanthanum carbonate.
Sprinkle the oral powder into a small amount of applesauce or other soft food (oral powder will not dissolve in liquid). Swallow right away without chewing. Do not save the mixture for later use.
While using lanthanum carbonate, you may need frequent blood tests.
Store at room temperature away from moisture and heat.
Skip the missed dose and use your next dose at the regular time. Do not use two doses at one time.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Avoid taking lanthanum carbonate at the same time you take your other medicines. Lanthanum carbonate can make it harder for your body to absorb other medicines you take by mouth.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
This medicine may cause severe bowel obstruction or a perforation (a hole or tear) in your intestines.
Call your doctor at once if you have:
severe stomach pain, bloating, or tenderness;
fever, chills, nausea, vomiting, loss of appetite;
severe constipation; or
bleeding from your rectum or blood in your stools;
Common side effects may include:
nausea, vomiting;
diarrhea; or
stomach pain.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Hyperphosphatemia of Renal Failure:
Initial dose: 1500 mg orally per day in divided doses with meals
Titrate in increments of 750 mg/day every 2 to 3 weeks until an acceptable serum phosphate level is reached
Maximum dose: 4500 mg/day
Comments:
-In addition to reduction of intestinal phosphate with phosphate binders, management of elevated serum phosphorus levels in ESRD requires reduction in dietary intake of phosphate and removal of phosphate by dialysis.
-Most patients will require daily doses between 1500 and 3000 mg to reduce plasma phosphate levels to less than 6 mg/dL.
Use: To reduce serum phosphate levels in patients with end stage renal disease.
Lanthanum carbonate can make certain medicines less effective when taken at the same time. If you take any of the following medicines, take them separately from your dose of lanthanum carbonate:
Thyroid medication: Take it at least 2 hours before or 2 hours after you take lanthanum carbonate.
An antibiotic such as ciprofloxacin (Cipro) or levofloxacin (Levaquin): Take it at least 1 hour before or 4 hours after you take lanthanum carbonate.
An antacid: Take it at least 2 hours before or 2 hours after you take lanthanum carbonate.
Other drugs may affect lanthanum carbonate, including prescription and over-the-counter medicines, vitamins, and herbal products. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Lanthanum Carbonate (www.drugs.com/mtm/lanthanum-carbonate.html).
Commonly reported side effects of lanthanum carbonate include: dialysis graft complication, nausea, and vomiting. Other side effects include: dialysis graft occlusion, and abdominal pain. See below for a comprehensive list of adverse effects.
Applies to lanthanum carbonate: oral powder, oral tablet chewable
Along with its needed effects, lanthanum carbonate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking lanthanum carbonate:
Incidence not known
Get emergency help immediately if any of the following symptoms of overdose occur while taking lanthanum carbonate:
Symptoms of overdose
Some side effects of lanthanum carbonate may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Incidence not known
Applies to lanthanum carbonate: oral powder for reconstitution, oral tablet chewable
The most common adverse reactions included nausea, vomiting, and abdominal pain.
Nausea, diarrhea, and vomiting occurred more frequently among patients taking the oral powder formulation than those receiving the chewable tablets (18% versus 7%).
Very common (10% or more): Nausea (up to 37%), vomiting (up to 27%), diarrhea (up to 24%), abdominal pain (up to 17%), constipation (up to 15%)
Common (1% to 10%): Dyspepsia, flatulence
Uncommon (0.1% to 1%): Gastroenteritis, eructation, indigestion, irritable bowel syndrome, dry mouth, stomatitis, loose stools, esophagitis, tooth disorder
Postmarketing reports: Tooth injury chewing the tablet, intestinal perforation, intestinal obstruction, ileus, subileus
Common (1% to 10%): Hypocalcemia
Uncommon (0.1% to 1%): Hypercalcemia, hyperglycemia, hyperphosphatemia, hypophosphatemia, anorexia, appetite increased, thirst
Common (1% to 10%): Bronchitis, rhinitis
Uncommon (0.1% to 1%): Laryngitis
Uncommon (0.1% to 1%): Hyperparathyroidism
Serum parathyroid concentrations may fluctuate depending on a patient's serum calcium, phosphate and vitamin D status. This drug has not been shown to have any direct effects on PTH secretion.
Postmarketing reports: Allergic skin reactions (skin rashes, urticaria, and pruritus)
The effects of this drug on the bones of patients undergoing dialysis have been evaluated in studies of up to 4.5 years duration. Compared with standard treatments including calcium carbonate, no differences in adverse effects on the musculoskeletal system, including fractures, were observed.
Uncommon (0.1% to 1%): Arthralgia, myalgia, osteoporosis
Uncommon (0.1% to 1%): Alopecia, increased sweating
Uncommon (0.1% to 1%): Vertigo, asthenia, fatigue, malaise
Uncommon (0.1% to 1%): Chest pain, peripheral edema
Uncommon (0.1% to 1%): Eosinophilia
Very common (10% or more): Headache (up to 22%)
Uncommon (0.1% to 1%): Dizziness, taste alteration
Very common (10% or more): Dialysis graft occlusion (up to 25%)
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Lanthanum Carbonate (www.drugs.com/mtm/lanthanum-carbonate.html).
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