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Note: This document contains side effect information about clonazepam. Some of the dosage forms listed on this page may not apply to the brand name Klonopin.
In SummaryCommon side effects of Klonopin include: drowsiness. Other side effects include: upper respiratory tract infection, ataxia, depression, and dizziness. See below for a comprehensive list of adverse effects.
For the ConsumerApplies to clonazepam: oral tablet, oral tablet disintegrating
Oral route (Tablet)
Concomitant use of benzodiazepines and opioids may result in profound sedation, respiratory depression, coma, and death. Reserve concomitant prescribing for patients with inadequate alternative treatment options. Limit dosages and durations to the minimum required and follow patients for signs and symptoms of respiratory depression and sedation.
Along with its needed effects, clonazepam (the active ingredient contained in Klonopin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking clonazepam:
More common
Less common
Rare
Incidence not known
Some side effects of clonazepam may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Rare
Incidence not known
For Healthcare Professionals
Applies to clonazepam: oral tablet, oral tablet disintegrating
GeneralThe most commonly reported side effects included drowsiness, somnolence, ataxia, and behavior problems.
Nervous systemReversible ataxia, dysarthria, anterograde amnesia, and nystagmus may occur, especially in long-term treatment and/or at high doses.
Transient somnolence, dizziness, ataxia, lightheadedness, muscular hypotonia, and/or coordination disturbances may occur, and usually disappear spontaneously when treatment is continued or upon dose reductions.
Very common (10% or more): Drowsiness (up to 50%), somnolence (up to 50%), ataxia (up to 30%), dizziness (up to 12%)
Common (1% to 10%): Abnormal coordination, dysarthria, intellectual ability reduced, memory disturbance, nystagmus
Rare (0.01% to 0.1%): Convulsions, headache
Very rare (less than 0.01%): Generalized fits, lightheadedness
Frequency not reported: Activation of new types of seizures, amnestic effects, anterograde amnesia/amnesia, aphonia, attention lack, coma, coordination disturbances, decreased movement and gait coordination, disturbance in attention, dysdiadochokinesis/inability to perform rapid, alternating movements, dysphagia, epileptic seizures, extremity numbness and tingling, forgetfulness, head fullness, hemiparesis, hyperactivity, hyperphagia, hypersensitivity to light/noise/physical contact, hypertonia, hypoesthesia, impaired concentration/poor concentration, lethargy, migraine, motion sickness, muscular hypotonia, paresis, paresthesia, seizures, speech slowing/slurring, taste loss, tremor, vertigo, visual field defect
Postmarketing reports: Choreiform movements, hypotonia, preexisting brain damage
PsychiatricReversible inappropriate behavior may occur, especially in long-term treatment and/or at high doses.
Very common (10% or more): Behavior problems (up to 25%)
Common (1% to 10%): Confusion/confusional state, decreased libido, depression, emotional lability, nervousness
Rare (0.01% to 0.1%): Decrease in sexual drive, loss of libido
Frequency not reported: Aggressive behavior/aggressive reaction/aggression/aggressiveness, agitation, anger, anxiety, apathy, depersonalization, derealization, disorientation, drug withdrawal symptoms, dysphoria, excessive dreaming, excitability/excitement, extreme anxiety, feeling mad, hallucinations, hostility, hysteria, illusion, inappropriate behavior, increased libido, insomnia, irritability, nightmares, organic disinhibition, physical dependence, psychological dependence, psychosis, psychotic disorders, restlessness, sleep disorder, sleep disturbance, suicidal attempt, suicide ideation, tension, vivid dreams, worsening/emergence of clinical depression
Postmarketing reports: Abnormal dreams, change in libido, dependence, encopresis
RespiratoryVery common (10% or more): Upper respiratory tract infection (up to 10%)
Common (1% to 10%): Bronchitis, coughing, pharyngitis, rhinitis, sinusitis
Rare (0.01% to 0.1%): Respiratory depression
Frequency not reported: Asthmatic attach, bronchial hypersecretion/hypersecretion in upper respiratory passages, chest congestion, dyspnea, excessive sneezing, hoarseness, mucus obstruction of the nasopharynx, nosebleed, pneumonia, rhinorrhea, shortness of breath, yawning
Postmarketing reports: Airway obstruction, pharyngeal edema
GenitourinaryCommon (1% to 10%): Colpitis, dysmenorrhea, ejaculation delayed, impotence, micturition frequency, urinary tract infection
Rare (0.01% to 0.1%): Erectile dysfunction, urinary incontinence
Frequency not reported: Bladder dysfunction, breast pain, dysuria, ejaculation decreased, enuresis/feeling of enuresis, menstrual irregularity, nocturia, pain pelvic, polyuria, urinary retention, urinary tract bleeding, urine discoloration
OtherTransient fatigue, lassitude, slowed reaction, and/or tiredness may occur, and usually disappear spontaneously when treatment is continued or upon dose reductions.
Common (1% to 10%): Fatigue, lassitude, tiredness
Frequency not reported: Accident, drunkenness, earache, fever, herpes simplex infection, hyperacusis, injury, malaise, otitis, pain, paradoxical reaction, reaction slowed/decreased, shivering, thirst, wound
Postmarketing reports: Falls, general deterioration
GastrointestinalCommon (1% to 10%): Abdominal pain, constipation
Rare (0.01% to 0.1%): Epigastric discomfort/symptoms, gastrointestinal symptoms, nausea
Frequency not reported: Abdominal discomfort, bowel movements frequent, coated tongue, dyspepsia, flatulence, gastrointestinal inflammation, hemorrhoids, pyrosis, salivary hypersecretion/saliva increased/hypersalivation, stomach upset, tongue thick, toothache, tooth disorder, vomiting
Postmarketing reports: Diarrhea, dry mouth, gastritis, sore gums
MusculoskeletalCommon (1% to 10%): Muscle weakness, myalgia
Frequency not reported: Ankle pain, arthralgia, back pain, foot pain, fracture traumatic, knee pain, knee swelling, jaw pain, leg cramps, leg pain, lumbago, muscle cramps, muscle pain, nape pain, shoulder pain, sprains, strains, tendinitis, twitching
Postmarketing reports: Fractures
HypersensitivityCommon (1% to 10%): Allergic reaction
Rare (0.01% to 0.1%): Angioedema
Frequency not reported: Anaphylaxis
OcularCommon (1% to 10%): Blurred vision
Frequency not reported: Diplopia/double vision, eye irritation, eye twitching, periorbital edema, stye, visual disturbance, xerophthalmia
Postmarketing reports: Abnormal eye movements, "glassy-eyed" appearance
Reversible vision disorders (e.g., diplopia) may occur, especially in long-term treatment and/or at high doses.
MetabolicCommon (1% to 10%): Appetite decreased
Frequency not reported: Anorexia, dehydration, gout, hunger abnormal, increased appetite, weight gain, weight loss
ImmunologicCommon (1% to 10%): Influenza
Frequency not reported: Infection mycotic, infection streptococcal, infection viral, moniliasis
DermatologicRare (0.01% to 0.1%): Pigmentation changes, pruritus, rash/skin rash, transient hair loss, urticaria
Frequency not reported: Abrasions, acne flare, alopecia/transient hair loss, bleeding dermal, burning skin, cellulitis, dermatitis contact, facial edema, hair loss, hirsutism, pustular reaction, skin disorder, sweating, xeroderma
Postmarketing reports: Angioneurotic edema, pigmentation disorder
HematologicRare (0.01% to 0.1%): Decreased platelet count
Frequency not reported: Anemia, blood dyscrasias, eosinophilia, infectious mononucleosis, leukopenia, lymphadenopathy
Postmarketing reports: Thrombocytopenia
CardiovascularFrequency not reported: Ankle edema, chest pain, edema, flushing, foot edema, palpitations, postural hypotension, tachycardia, thrombophlebitis leg
Postmarketing reports: Cardiac arrest, cardiac failure, thrombophlebitis, thrombosis
Tachycardia occurred after IV administration.
HepaticFrequency not reported: Abnormal liver function tests, hepatomegaly
Postmarketing reports: Transient elevations of serum transaminases and alkaline phosphatase
EndocrineFrequency not reported: Incomplete precocious puberty/premature secondary sex characteristics
LocalFrequency not reported: Localized inflammation
RenalFrequency not reported: Cystitis
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Klonopin (www.drugs.com/klonopin.html).
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