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Kisqali femara 400 dose

Generic Name: ribociclib (RYE boe SYE klib)
Brand Names: Kisqali
Kisqali (ribociclib) is used to treat a certain type of advanced metastatic breast cancer. Includes Kisqali side effects, interactions and indications.
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Drug Information:
Kisqali (ribociclib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Kisqali is used to treat hormone-related breast cancer in women. Ribociclib is used only if your cancer tests negative for a protein called human epidermal growth factor receptor 2 (HER2). HER2 protein can speed the growth of cancer cells. Kisqali is used when the cancer has progressed or has spread to other parts of the body after other treatments. Kisqali is given in combination with another cancer medicine such as Letrozole (Femara) or fulvestrant (Faslodex). Learn more

Kisqali femara 400 dose Side Effects

Kisqali Side Effects

Note: This document contains side effect information about ribociclib. Some of the dosage forms listed on this page may not apply to the brand name Kisqali.

For the Consumer

Applies to ribociclib: oral tablet

Along with its needed effects, ribociclib (the active ingredient contained in Kisqali) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ribociclib:

More common

  • Black, tarry, stools
  • bladder pain
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • bloody or cloudy urine
  • chills
  • cough
  • difficult or labored breathing
  • difficult, burning, or painful urination
  • fever
  • frequent urge to urinate
  • lower back or side pain
  • pale skin
  • rapid weight gain
  • sore throat
  • tightness in the chest
  • tingling of the hands or feet
  • troubled breathing with exertion
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss

Less common

  • Fainting
  • irregular heartbeat recurrent

Some side effects of ribociclib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back pain
  • decreased appetite
  • diarrhea
  • difficulty having a bowel movement
  • hair loss or thinning of the hair
  • headache
  • nausea
  • rash or itching skin
  • stomach pain
  • swelling or inflammation of the mouth
  • trouble sleeping
  • vomiting

For Healthcare Professionals

Applies to ribociclib: oral tablet

General

-The most common adverse reactions (reported at a frequency 20% or more) were neutropenia, nausea, fatigue, diarrhea, leukopenia, alopecia, vomiting, constipation, headache, and back pain.

-The most common laboratory abnormalities (reported at a frequency 20% or more) were decreased leukocyte count, decreased neutrophil count, decreased hemoglobin, decreased lymphocyte count, increased ALT, increased AST, decreased platelet count, and increased creatinine.

Hematologic

Very common (10% or more): Decreased leukocyte count (93%), decreased neutrophil count (93%), neutropenia (75%), decreased hemoglobin (57%), decrease lymphocyte count (51%), leukopenia (33%), decreased platelet count (29%), anemia (18%), lymphopenia (11%)

Gastrointestinal

Very common (10% or more): Nausea (52%), diarrhea (35%), vomiting (29%), constipation (25%), stomatitis (12%), abdominal pain (11%)

Hepatic

Very common (10% or more): Increased ALT (46%), increased AST (44%), abnormal liver function tests (18%), decreased appetite

Frequency not reported: Increased blood bilirubin

Other

Very common (10% or more): Fatigue (37%), pyrexia (13%), peripheral edema (12%)

Uncommon (0.1% to 1%): On-treatment deaths, sudden death

Dermatologic

Very common (10% or more): Alopecia (33%), rash (17%), pruritus (14%)

Nervous system

Very common (10% or more): Headache (22%), insomnia (12%)

Common (1% to 10%): Syncope

Metabolic

Very common (10% or more): Increased creatinine (20%), decreased appetite (19%), decreased phosphorous (13%), decreased potassium (11%)

Musculoskeletal

Very common (10% or more): Back pain (20%)

Respiratory

Very common (10% or more): Dyspnea (12%)

Common (1% to 10%): Epistaxis

Genitourinary

Very common (10% or more): Urinary tract infection (11%)

Cardiovascular

Frequency not reported: QT interval prolongation

Ocular

Common (1% to 10%): Lacrimation increased, dry eye

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Kisqali Femara 400 Dose (www.drugs.com/kisqali.html).