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Generic Name: sodium polystyrene sulfonate (SOE dee um pol ee STEER een SUL foe nate)
Brand Name: Kalexate, Kayexalate, Kionex
Physician reviewed Kionex patient information - includes Kionex description, dosage and directions.
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Drug Information:
Kionex binds itself to Potassium in your digestive tract. This helps prevent your body from absorbing too much Potassium. Kionex is used to treat high levels of Potassium in the blood, also called hyperkalemia. Kionex works differently from other medicines because it passes into your intestines without being absorbed into your blood stream. Kionex may also be used for purposes not listed in this medication guide. You should not use Kionex if you have low Potassium levels or a bowel obstruction. Learn more

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Kionex Side Effects

Note: This document contains side effect information about sodium polystyrene sulfonate. Some of the dosage forms listed on this page may not apply to the brand name Kionex.

For the Consumer

Applies to sodium polystyrene sulfonate: oral or rectal powder for suspension, oral or rectal suspension

Side effects include:

Gastric irritation, anorexia, constipation, diarrhea, fecal impaction, GI concretions (bezoars), nausea, vomiting, hypokalemia, hypocalcemia, hypomagnesemia, clinically important sodium retention.

For Healthcare Professionals

Applies to sodium polystyrene sulfonate: oral suspension, oral and rectal powder, oral and rectal suspension, rectal enema


Rare (0.01% to 0.1%): Intestinal/colonic necrosis

Frequency not reported: Gastric irritation, nausea, vomiting, constipation, diarrhea, fecal impaction, intestinal obstruction, other serious gastrointestinal (GI) adverse reactions

Postmarketing reports: GI concretions/bezoars, ischemic colitis, GI tract ulceration, intestinal perforation, GI stenosis

Nausea, vomiting, and constipation have occurred, especially with high doses. In clinical trials, fecal impaction occurred in geriatric patients given large doses; children have experienced impaction with rectal administration. Following oral administration, intestinal obstruction with aluminum hydroxide concretions and bezoar formation occurred in neonates. In postmarketing reports, gastrointestinal tract ulcerations, necrosis, and ischemic colitis may have resulted in intestinal perforation.


Frequency not reported: Anorexia, hypokalemia, hypocalcemia, hypomagnesemia, significant sodium retention

Nervous system

Postmarketing reports: Grand mal seizure

A grand mal seizure occurred in 1 patient with renal dysfunction and concomitant use of this drug and magnesium hydroxide.


Postmarketing reports: Acute bronchitis, bronchopneumonia

Bronchitis with/without pneumonia occurred after inhalation of particles of this drug.

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Kionex (www.drugs.com/mtm/kionex.html).