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Keytruda

Generic Name: pembrolizumab (PEM broe LIZ ue mab)
Brand Names: Keytruda
Keytruda (pembrolizumab) is used to treat advanced melanoma, non-small cell lung cancer, small cell lung cancer, head and neck squamous cell carcinoma, classical Hodgkin lymphoma, primary mediastinal large B-cell lymphoma, urothelial carcinoma, microsatellite instability-high cancer, gastric cancer, esophageal cancer, cervical cancer, hepatocellular carcinoma, Merkel cell carcinoma, renal cell carcinoma, and endometrial carcinoma. Includes Keytruda side effects, interactions and indications.
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Drug Information:
Keytruda (pembrolizumab) is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Keytruda is used alone or in combination with other medicines to treat certain types of cancer such as: advanced skin cancer (melanoma or Merkel cell carcinoma); lung cancer; small cell lung cancer; head and neck cancer; Classical Hodgkin lymphoma in adults and children; primary mediastinal large B-cell lymphoma; cancer of the kidney, bladder, and urinary tract; liver; cancer of the cervix or uterus; Learn more

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Keytruda Side Effects

Note: This document contains side effect information about pembrolizumab. Some of the dosage forms listed on this page may not apply to the brand name Keytruda.

In Summary

More frequent side effects include: hyperthyroidism. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to pembrolizumab: intravenous solution

Along with its needed effects, pembrolizumab (the active ingredient contained in Keytruda) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking pembrolizumab:

More common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • body aches or pain
  • chills
  • constipation
  • cough
  • depressed mood
  • difficulty with breathing
  • difficulty with moving
  • dry skin and hair
  • ear congestion
  • feeling cold
  • fever
  • hair loss
  • headache
  • hoarseness or husky voice
  • loss of voice
  • muscle cramps, pain, and stiffness
  • pain in the joints
  • pale skin
  • rapid weight gain
  • runny or stuffy nose
  • slowed heartbeat
  • sneezing
  • sore throat
  • tingling of the hands or feet
  • trouble breathing
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss

Less common

  • Chest pain
  • general feeling of discomfort or illness
  • nervousness
  • pain
  • sensitivity to heat
  • stomach cramps
  • sweating
  • tenderness
  • thickening of bronchial secretions
  • trouble sleeping
  • watery or bloody diarrhea
  • weight loss

Rare

  • Back, leg, or stomach pains
  • bleeding gums
  • blurred vision or other change in vision
  • cracks in the skin
  • darkened urine
  • drowsiness
  • eye pain
  • fast heartbeat
  • general body swelling
  • general tiredness and weakness
  • indigestion
  • light-colored stools
  • loss of appetite
  • loss of heat from the body
  • nausea
  • nosebleeds
  • pain, swelling, or redness in the joints
  • pains in the stomach, side, or abdomen, possibly radiating to the back
  • pale skin
  • red, swollen skin
  • redness of the eye
  • scaly skin
  • seizures
  • sensitivity of the eye to light
  • tearing
  • upper right abdominal or stomach pain
  • vomiting
  • yellow eyes and skin

Some side effects of pembrolizumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Decreased appetite
  • diarrhea
  • dizziness
  • rash

For Healthcare Professionals

Applies to pembrolizumab: intravenous powder for injection, intravenous solution

Cardiovascular

Very common (10% or more): Peripheral edema (up to 17%)

Dermatologic

Very common (10% or more): Pruritus (up to 30%), rash (up to 29%), vitiligo (up to 11%)

Uncommon (0.1% to 1%): Exfoliative dermatitis

Endocrine

Very common (10% or more): Hyperglycemia (up to 40%), hypertriglyceridemia (up to 25%)

Common (1% to 10%): Hypothyroidism, hyperthyroidism

Uncommon (0.1% to 1%): Hypophysitis, adrenal insufficiency

Gastrointestinal

Very common (10% or more): Nausea (up to 30%), constipation (up to 21%), diarrhea (up to 20%), vomiting (up to 16%), abdominal pain (up to 12%)

Common (1% to 10%): Colitis

Uncommon (0.1% to 1%): Pancreatitis

Hematologic

Very common (10% or more): Anemia (up to 55%), immune-mediated hemolytic anemia

Hepatic

Very common (10% or more): Hypoalbuminemia (up to 34%), increased aspartate aminotransferase (up to 24%)

Uncommon (0.1% to 1%): Hepatitis

Metabolic

Very common (10% or more): Hyponatremia (up to 35%), decreased appetite (up to 26%), hypocalcemia (up to 24%)

Musculoskeletal

Very common (10% or more): Arthralgia (up to 20%), pain in extremity (up to 18%), myalgia (up to 14%), back pain (up to 12%)

Uncommon (0.1% to 1%): Arthritis, myositis, myasthenic syndrome, rhabdomyolysis

Nervous system

Very common (10% or more): Headache (up to 16%), dizziness (up to 11%)

Uncommon (0.1% to 1%): Partial seizures

Ocular

Uncommon (0.1% to 1%): Uveitis, optic neuritis

Other

Very common (10% or more): Fatigue (up to 47%), chills (up to 14%), pyrexia (up to 11%), sepsis (up to 10%)

Psychiatric

Very common (10% or more): Insomnia (up to 14%)

Renal

Uncommon (0.1% to 1%): Nephritis, renal failure

Respiratory

Very common (10% or more): Cough (up to 30%), dyspnea (up to 18%), upper respiratory tract infection (up to 11%)

Common (1% to 10%): Pneumonitis

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Keytruda (www.drugs.com/keytruda.html).