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Kevzara

Generic Name: sarilumab (sar IL ue mab)
Brand Names: Kevzara
Kevzara (sarilumab) is used to treat rheumatoid arthritis. Includes Kevzara side effects, interactions and indications.
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Drug Information:
Kevzara (sarilumab) reduces the effects of a substance in the body that can cause inflammation. Kevzara is used to treat moderate to severe rheumatoid arthritis in adults. Itis sometimes given together with other arthritis medicines. Kevzara is usually given after other medications have been tried without successful treatment of symptoms. Kevzara affects your immune system. You may get infections more easily, even serious or fatal infections. Tell your doctor if you have a fever, chills, tiredness, cough, diarrhea, stomach pain, weight loss, skin sores, or painful urination. Learn more

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Kevzara Side Effects

Note: This document contains side effect information about sarilumab. Some of the dosage forms listed on this page may not apply to the brand name Kevzara.

For the Consumer

Applies to sarilumab: subcutaneous solution

Warning

Subcutaneous route (Solution)

Serious infections leading to hospitalization or death including bacterial, viral, invasive fungal, and other opportunistic infections have occurred in patients receiving sarilumab.If a serious infection develops, interrupt sarilumab until the infection is controlled.Cases of tuberculosis (TB) have been reported. Prior to starting sarilumab, test for latent TB; if positive, start treatment for TB.Closely monitor patients for signs and symptoms of infection during treatment with sarilumab.

Along with its needed effects, sarilumab (the active ingredient contained in Kevzara) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking sarilumab:

More common

  • Bloody, black, or tarry stools
  • chills
  • cough
  • fever
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • sore throat
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common

  • Bladder pain
  • bloody or cloudy urine
  • body ache or pain
  • difficulty breathing
  • ear congestion
  • frequent urge to urinate
  • headache
  • loss of voice
  • nasal congestion
  • painful cold sores or blisters on the lips
  • runny nose
  • sneezing

Rare

  • Difficulty swallowing
  • dizziness
  • fast heartbeat
  • heartburn
  • hives, itching, skin rash
  • indigestion
  • nausea
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • severe stomach pain, cramping, or burning
  • tightness in the chest
  • vomiting of material that looks like coffee grounds, severe and continuing

Some side effects of sarilumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bleeding, blistering, burning, coldness, discoloration of skin, feeling of pressure, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site

For Healthcare Professionals

Applies to sarilumab: subcutaneous solution

Dermatologic

Frequency not reported: Cellulitis

Hematologic

Common (1% to 10%): Neutropenia, leukopenia

Uncommon (0.1% to 1%): Decreased platelet counts

Frequency not reported: Thrombocytopenia

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity reactions

Immunologic

Common (1% to 10%): Serious (sometimes fatal) infections due to bacterial, mycobacterial, invasive fungal, viral, or other opportunistic pathogens which can be chronic or recurrent

Frequency not reported: Immunosuppression

Local

Common (1% to 10%): Injection site reactions (e.g., erythema, pruritus)

Metabolic

Common (1% to 10%): Lipid abnormalities (elevated LDL, HDL, and triglycerides)

Genitourinary

Common (1% to 10%): Urinary tract infection

Hepatic

Very common (10% or more): Elevated alanine aminotransferase (ALT) (up to 43%), elevated aspartate aminotransferase (AST) (up to 30%)

Respiratory

Common (1% to 10%): Upper respiratory tract infection

Frequency not reported: Pneumonia

General

The most frequent adverse reactions (occurring in at least 3% of patients treated with this drug in combination with DMARDs) were neutropenia, increased ALT, injection site erythema, upper respiratory infections, and urinary tract infections.

Gastrointestinal

Frequency not reported: GI perforation

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Kevzara (www.drugs.com/kevzara.html).