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Ketoprofen Micronized

Ketoprofen micronized Prescription
Generic Name: ketoprofen (kee toe PROE fen)
Brand Name: Oruvail, Orudis, Actron, Orudis KT
Physician reviewed ketoprofen patient information - includes ketoprofen description, dosage and directions.
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Ketoprofen Micronized Drug Information:

Ketoprofen is a nonsteroidal anti-inflammatory drug (NSAID). Ketoprofen works by reducing hormones that cause inflammation and pain in the body. Ketoprofen is used to treat pain or inflammation caused by arthritis. The Ketoprofen regular capsule is also used to treat mild to moderate pain, or menstrual pain. Only Ketoprofen extended-release capsules are used for treating arthritis. This form of Ketoprofen will not work fast enough to treat acute pain. Ketoprofen may also be used for purposes not listed in this medication guide. Learn more

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Ketoprofen Micronized Side Effects

In Summary

Commonly reported side effects of ketoprofen include: dyspepsia. Other side effects include: abdominal pain, constipation, diarrhea, edema, headache, increased blood urea nitrogen, nausea, renal insufficiency, and flatulence. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ketoprofen: oral capsule, oral capsule extended release


Oral route (Tablet; Capsule; Capsule, Extended Release)

NSAIDs may cause an increased risk of serious cardiovascular thrombotic events, myocardial infarction, and stroke, which can be fatal. This risk may be increased in patients with cardiovascular disease or risk factors for cardiovascular disease. Ketoprofen is contraindicated for the treatment of perioperative pain in the setting of CABG surgery. NSAIDs can also cause an increased risk of serious gastrointestinal adverse events especially in the elderly, including bleeding, ulceration, and perforation of the stomach or intestines, which can be fatal.

Along with its needed effects, ketoprofen may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ketoprofen:

More common

  • Abdominal pain
  • bloody urine
  • decreased frequency or amount of urine
  • headache
  • increased blood pressure
  • increased thirst
  • loss of appetite
  • lower back or side pain
  • nausea
  • swelling of face, fingers, feet, or lower legs
  • troubled breathing
  • unusual tiredness or weakness
  • vomiting
  • weight gain

Less common

  • Bladder pain
  • cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • rash
  • swelling or inflammation of the mouth


  • Back pain
  • bleeding from rectum
  • bleeding gums
  • blistering, peeling, loosening of skin
  • blood in vomit
  • bloody nose
  • bloody, black, or tarry stools
  • blurred vision
  • body aches or pain
  • burning feeling in chest or stomach
  • burning, dry or itching eyes
  • change in color of eye
  • chest pain
  • chills
  • clay-colored stools
  • cold hands and feet
  • coma
  • confusion
  • congestion
  • constipation
  • convulsions
  • cough or hoarseness
  • coughing or spitting up blood
  • cracks in the skin
  • dark urine
  • decreased urination
  • decreased vision or other changes in vision
  • diarrhea
  • difficult or labored breathing
  • difficulty swallowing
  • dilated neck veins
  • discharge, excessive tearing
  • dryness or soreness of throat
  • extreme fatigue
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling faint, dizzy, or lightheadedness
  • feeling of warmth or heat
  • fever with or without chills
  • flushing or redness of skin, especially on face and neck
  • general tiredness and weakness
  • heartburn
  • hives or welts
  • increased sensitivity of skin to sunlight
  • indigestion
  • itching
  • joint or muscle pain
  • light-colored stools
  • loss of heat from the body
  • muscle pain or cramps
  • nervousness
  • noisy breathing
  • pale or blue lips, fingernails, or skin
  • pale skin
  • pinpoint red or purple spots on skin
  • pounding in the ears
  • problems with bleeding or clotting
  • puffiness or swelling of the eyelids or around the eyes, face, lips or tongue
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • red, swollen skin
  • redness or other discoloration of skin
  • redness or soreness around fingernails or loosening of the fingernails
  • redness, pain, swelling of eye, eyelid, or inner lining of eyelid
  • runny nose
  • scaly skin
  • severe abdominal cramping
  • severe or continuing stomach pain
  • severe sunburn
  • shortness of breath
  • skin rash, encrusted, scaly and oozing
  • slow heartbeat
  • slow or irregular breathing
  • sores, ulcers, or white spots on lips or in mouth
  • stomach pain or upset
  • sweating
  • swelling of face, ankles, or hands
  • tender, swollen glands in neck
  • tenderness in stomach area
  • tightness in chest
  • trouble in swallowing
  • troubled breathing with exertion
  • unpleasant breath odor
  • unusual bleeding or bruising
  • upper right abdominal pain
  • voice changes
  • vomiting of blood
  • vomiting of material that looks like coffee grounds, severe and continuing
  • wheezing
  • yellow eyes or skin

Symptoms of overdose

  • Dizziness, faintness, or lightheadedness when getting up from a lying or sitting position suddenly
  • fast or shallow breathing
  • pain or discomfort in chest, upper stomach, or throat
  • unusual drowsiness, dullness, tiredness, weakness or feeling of sluggishness

Some side effects of ketoprofen may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Acid or sour stomach
  • belching
  • bloated
  • discouragement
  • dreams
  • excess air or gas in stomach or intestines
  • excitation
  • feeling sad or empty
  • full feeling
  • general feeling of discomfort or illness
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • passing gas
  • sleepiness
  • sleeplessness
  • trouble concentrating
  • trouble sleeping
  • unable to sleep

Less common

  • Continuing ringing or buzzing or other unexplained noise in ears
  • disturbed color perception
  • double vision
  • halos around lights
  • hearing loss
  • loss of vision
  • night blindness
  • overbright appearance of lights
  • tunnel vision
  • weight loss

For Healthcare Professionals

Applies to ketoprofen: compounding powder, oral capsule, oral capsule extended release, oral tablet


The most frequently reported side effects were gastrointestinal in nature and included dyspepsia, abdominal pain, nausea, diarrhea, constipation, and flatulence.


Very common (10% or more): Dyspepsia (up to 11.5%)

Common (1% to 10%): Abdominal pain, diarrhea, constipation, flatulence, anorexia, vomiting, stomatitis, nausea, gastralgia

Uncommon (0.1% to 1%): Gastritis

Rare (0.01% to 0.1%): Peptic ulcer

Very rare (less than 0.01%): Pancreatitis

Frequency not reported: Dry mouth, eructation, gastritis, rectal hemorrhage, melena, fecal occult blood, salivation, gastrointestinal (GI) perforation, hematemesis, intestinal ulceration, buccal necrosis, ulcerative colitis, microvesicular steatosis, ulcerative colitis exacerbated, Crohn's disease exacerbated, GI bleeding, mouth ulcer, sore tongue, GI hemorrhage

Nervous system

Common (1% to 10%): Headache, central nervous system (CNS) inhibition, CNS excitation, somnolence, dizziness

Rare (less than 0.1%): Paresthesia

Frequency not reported: Amnesia, migraine, taste perversion, convulsions, drowsiness, dysgeusia, optic neuritis


Frequency not reported: Hypertension, palpitation, tachycardia, congestive heart failure, peripheral vascular disease, vasodilation, shock, arrhythmia, myocardial infarction, heart failure exacerbated, atrial fibrillation, flushing, vasculitis


Rare (less than 0.1%): Hepatitis, transaminases increased, bilirubin elevated

Frequency not reported: Hepatic dysfunction, hepatitis, cholestatic hepatitis, jaundice, liver function abnormal


Frequency not reported: Renal failure/acute renal failure, interstitial nephritis, nephrotic syndrome, renal function tests abnormal, acute tubulopathy


Common (1% to 10%): Depression, insomnia, nervousness

Frequency not reported: Confusion, dysphoria, hallucination, libido disturbance, nightmares, personality disorder, tension, anxiety, mood altered


Common (1% to 10%): Rash

Uncommon (0.1% to 1%): Pruritus

Frequency not reported: Purpura, alopecia, eczema, purpuric rash, sweating, urticaria, bullous rash, exfoliative dermatitis, photosensitivity, skin discoloration, onycholysis, toxic epidermal necrolysis, erythema multiforme, Stevens-Johnson syndrome, angioedema, leukocytoclastic vasculitis, acute generalized exanthematous pustulosis, bruising


Common (1% to 10%): Visual disturbance

Frequency not reported: Conjunctivitis, conjunctivitis sicca, eye pain, retinal hemorrhage, retinal pigmentation change


Common (1% to 10%): Urinary tract irritated

Frequency not reported: Impotence, menometrorrhagia, hematuria, gynecomastia


Rare (less than 0.1%): Anemia, hemorrhagic anemia

Frequency not reported: Hypocoagulability, agranulocytosis, hemolysis, thrombocytopenia, neutropenia, bone marrow failure, bone marrow aplasia, hemolytic anemia, leukopenia


Rare (less than 0.1%): Asthma/asthma attack

Frequency not reported: Dyspnea, hemoptysis, epistaxis, pharyngitis, rhinitis, bronchospasm, laryngeal edema


Frequency not reported: Appetite increased, hyponatremia, diabetes mellitus aggravated, hyperkalemia


Frequency not reported: Myalgia


Rare (less than 0.1%): Anaphylaxis

Frequency not reported: Allergic reaction


Frequency not reported: Rectal bleeding, rectal pain, rectal burning, rectal pruritus, rectal tenesmus


Common (1% to 10%): Malaise, tinnitus, edema, BUN increased

Uncommon (0.1% to 1%): Fatigue

Rare (less than 0.1%): Weight gain

Frequency not reported: Infection, pain, facial edema, chills, weight loss, thirst, vertigo, hearing impaired, septicemia, aseptic meningitis

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Ketoprofen Micronized (www.drugs.com/mtm/ketoprofen.html).