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Ixempra kit

Generic Name: ixabepilone (IX ab EP i lone)
Brand Names: Ixempra
Ixempra is used to treat advanced breast cancer. Learn about side effects, interactions and indications.
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Drug Information:
Ixempra (ixabepilone) is used to treat advanced breast cancer. Ixempra is usually given after other cancer medications have been tried without successful treatment. Ixempra may also be used for purposes not listed in this medication guide. Do not use Ixempra if you are pregnant. It could harm the unborn baby. You should not receive Ixempra if you are allergic to ixabepilone, or to a medication ingredient called Cremophor (synthetic castor oil). You may not be able to receive Ixempra if you have severe liver disease, or severely low platelets or white blood cell counts. Learn more

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Ixempra kit Side Effects

Ixempra Side Effects

Note: This document contains side effect information about ixabepilone. Some of the dosage forms listed on this page may not apply to the brand name Ixempra.

For the Consumer

Applies to ixabepilone: intravenous powder for solution

Warning

Intravenous route (Powder for Solution)

Ixabepilone in combination with capecitabine is contraindicated in patients with AST or ALT greater than 2.5 times the ULN or bilirubin greater than 1 time the ULN due to an increased risk of toxicity and neutropenia-related death.

Along with its needed effects, ixabepilone (the active ingredient contained in Ixempra) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ixabepilone:

More common

  • Black, tarry stools
  • body aches or pain
  • burning, numbness, tingling, or painful sensations
  • burning pain on urination
  • chest pain
  • chills
  • cough
  • difficult or labored breathing
  • ear congestion
  • fever
  • headache
  • loss of voice
  • lower back or side pain
  • nasal congestion
  • painful or difficult urination
  • pale skin
  • red, swelling, or painful skin
  • runny nose
  • scaling of the skin on the hands and feet
  • shortness of breath
  • sneezing
  • sore throat
  • sores, ulcers, or white spots on the lips, tongue, or inside the mouth
  • swelling of the hands, ankles, feet, or lower legs
  • swollen glands
  • tightness in the chest
  • tingling of the hands and feet
  • troubled breathing with exertion
  • ulceration of the skin
  • unsteadiness or awkwardness
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain
  • weakness in the arms, hands, legs, or feet
  • wheezing

Less common

  • Bleeding gums
  • blood in the urine or stools
  • confusion
  • decreased urination
  • dizziness
  • dry mouth
  • fainting
  • fast heartbeat
  • hives
  • hoarseness
  • increase in heart rate
  • irritation
  • itching
  • joint pain, stiffness, or swelling
  • lightheadedness
  • pinpoint red spots on the skin
  • rapid breathing
  • rash
  • sunken eyes
  • swelling of the eyelids, face, or lips
  • thirst
  • trouble with swallowing
  • wrinkled skin

Some side effects of ixabepilone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Bad, unusual, or unpleasant (after) taste
  • bone pain
  • change in taste
  • cracked lips
  • diarrhea
  • difficulty having a bowel movement (stool)
  • discoloration of the fingernails or toenails
  • feeling of warmth
  • hair loss or thinning of the hair
  • heartburn
  • lack or loss of strength
  • loss of appetite
  • nausea
  • redness of the face, neck, arms, and occasionally, upper chest
  • stomach pain
  • sudden sweating
  • swelling or inflammation of the mouth
  • vomiting
  • weight loss

Less common

  • Darkening of the skin
  • flaking and falling off of the skin
  • sleeplessness
  • trouble with sleeping
  • unable to sleep
  • watering of the eyes

For Healthcare Professionals

Applies to ixabepilone: intravenous powder for injection

Hematologic

Very common (10% or more): Neutropenia (Grade 4) (36%), leukopenia (41%)

Common (1% to 10%): Febrile neutropenia, infection with neutropenia, anemia, thrombocytopenia

Frequency not reported: Coagulopathy, lymphopenia, hemorrhage

Hypersensitivity

Common (1% to 10%): Flushing, rash, dyspnea, bronchospasm, anaphylaxis

Nervous system

Very common (10% or more): Peripheral neuropathy (all Grades) (67%), sensory neuropathy (65%), peripheral neuropathy (Grade 3 or 4) (23%), motor neuropathy (16%), taste disorder (12%)

Common (1% to 10%): Headache, dizziness

Frequency not reported: Cognitive disorder, syncope, cerebral hemorrhage, abnormal coordination, lethargy

Cardiovascular

Common (1% to 10%): Myocardial ischemia, ventricular dysfunction, hot flush

Uncommon (0.1% to 1%): Supraventricular arrhythmia

Frequency not reported: Myocardial infarction, supraventricular arrhythmia, left ventricular dysfunction, angina pectoris, atrial flutter, cardiomyopathy, myocardial ischemia, hypotension, thrombosis, embolism, hypovolemic shock, vasculitis

Musculoskeletal

Very common (10% or more): Myalgia/arthralgia (39%), musculoskeletal pain (23%)

Frequency not reported: Muscular weakness, muscle spasms, trismus

Gastrointestinal

Very common (10% or more): Nausea (53%), abdominal pain (24%), constipation (22%), stomatitis/mucositis, diarrhea

Common (1% to 10%): Dehydration, gastroesophageal reflux disease

Frequency not reported: Enterocolitis, ileus, colitis, impaired gastric emptying, esophagitis, dysphagia, gastritis, GI hemorrhage

Dermatologic

Very common (10% or more): Palmar-plantar erythrodysesthesia syndrome (64%), alopecia (31%), nail disorder (24%), skin rash (17%), skin hyperpigmentation (14%)

Common (1% to 10%): Pruritus, skin exfoliation

Frequency not reported: Erythema multiforme

Postmarketing reports: Radiation recall

Respiratory

Common (1% to 10%): Upper respiratory tract infection, dyspnea, cough

Frequency not reported: Pneumonia, laryngitis, lower respiratory tract infection, pneumonitis, hypoxia, respiratory failure, acute pulmonary edema, dysphonia, pharyngolaryngeal pain

Hepatic

Frequency not reported: Acute hepatic failure, jaundice, increased transaminases, increased blood alkaline phosphatase, increased gamma-glutamyltransferase

Renal

Frequency not reported: Nephrolithiasis, renal failure

Metabolic

Very common (10% or more): Anorexia (34%), weight loss (11%)

Frequency not reported: Hyponatremia, metabolic acidosis, hypokalemia, hypovolemia

Ocular

Common (1% to 10%): Increased lacrimation

Other

Very common (10% or more): Fatigue/asthenia (60%), pyrexia (10%)

Common (1% to 10%): Edema, pain, chest pain

Frequency not reported: Chills

Immunologic

Frequency not reported: Sepsis, infection, neutropenic infection, bacterial infection

Psychiatric

Common (1% to 10%): Insomnia

Genitourinary

Frequency not reported: Urinary tract infection

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Ixempra Kit (www.drugs.com/ixempra.html).