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Istalol Prescription
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Generic Name: timolol ophthalmic (TIM oh lol off THAL mik)
Brand Names: Betimol, Istalol, Timoptic Ocudose, Timoptic Ocumeter, Timoptic Ocumeter Plus, Timoptic-XE
Istalol ophthalmic (for the eyes) is a beta-blocker that is used to treat open-angle glaucoma and other causes of high pressure inside the eye. Average Savings for timolol maleate (generic): 43.8%
Generic Name: timolol ophthalmic (TIM oh lol off THAL mik)
Brand Names: Betimol, Istalol, Timoptic Ocudose, Timoptic Ocumeter, Timoptic Ocumeter Plus, Timoptic-XE
Istalol ophthalmic (for the eyes) is a beta-blocker that is used to treat open-angle glaucoma and other causes of high pressure inside the eye. Average Savings for timolol maleate (generic): 43.8%
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30 tablets of Istalol 40 mg
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Istalol Drug Information:

Istalol (timolol) is a beta-blocker that also reduces pressure inside the eye. Istalol ophthalmic solution is used to treat open-angle glaucoma and other causes of high pressure inside the eye. Istalol may also be used for purposes not listed in this medication guide. You should not use Istalol if you have asthma or severe COPD, or a serious heart condition (such as "sick sinus syndrome," 2nd or 3rd degree "AV block," severe heart failure, or very slow heartbeats). Side effects may occur if timolol is absorbed into your bloodstream. Call your doctor right away if you have: chest pain, trouble breathing, slow heartbeats, muscle weakness, numbness or coldness in your hands or feet, unusual mood or behavior changes, or severe dizziness. Learn more

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Istalol Side Effects

Note: This document contains side effect information about timolol ophthalmic. Some of the dosage forms listed on this page may not apply to the brand name Istalol.

For the Consumer

Applies to timolol ophthalmic: ophthalmic gel forming solution, ophthalmic solution

Along with its needed effects, timolol ophthalmic (the active ingredient contained in Istalol) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking timolol ophthalmic:

More common

  • Blurred vision
  • burning or stinging in the eye

Less common

  • Arm, back, or jaw pain
  • blisters, hives, welts, or itching
  • blue lips, fingernails, or skin
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in vision
  • chest pain or discomfort
  • chest tightness or heaviness
  • confusion about identity, place, and time
  • continuing ringing or buzzing or other unexplained noise in ears
  • coughing that sometimes produces a pink frothy sputum
  • depression
  • difficult, fast, noisy breathing
  • difficulty with chewing, swallowing, or talking
  • dilated neck veins
  • discharge, excessive tearing
  • disturbed color perception
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • double vision
  • drooping eyelids
  • dry or itching eyes
  • extreme fatigue
  • false sense of well-being
  • fast, slow, irregular, pounding, or racing heartbeat or pulse
  • fear or nervousness
  • feeling of having something in the eye
  • fever and chills
  • flashes of light, floaters in vision
  • general feeling of discomfort or illness
  • hair loss
  • halos around lights
  • headache
  • inability to speak
  • increased sweating
  • irregular, fast or slow, or shallow breathing
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lightheadedness, dizziness, or fainting
  • loss of vision
  • memory loss
  • mood swings
  • muscle or joint pain
  • muscle weakness
  • nausea
  • night blindness
  • no blood pressure or pulse
  • overbright appearance of lights
  • pain, tension, and weakness upon walking that subsides during periods of rest
  • pale skin
  • paleness or cold feeling in the fingertips, toes, hands, and feet
  • personality changes
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redness of the skin
  • redness, pain, swelling or irritation of the eye, eyelid, or inner lining of the eyelid
  • seeing double
  • seeing, hearing, or feeling things that are not there
  • seizures
  • severe numbness, especially on one side of the face or body
  • severe or sudden headache
  • severe tiredness
  • skin irritation or rash, including rash that looks like psoriasis
  • slurred speech
  • sore throat
  • stopping of heart
  • sweating
  • swelling of the face, fingers, feet, lower legs, and ankles
  • swollen glands
  • temporary blindness
  • tingling or pain in the fingers or toes when exposed to cold
  • tunnel vision
  • unconsciousness
  • unusual tiredness or weakness
  • weakness in arm and/or leg on one side of the body, sudden and severe
  • weight gain

Some side effects of timolol ophthalmic may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Acid or sour stomach
  • belching
  • body aches or pain
  • diarrhea
  • dry mouth
  • ear congestion
  • hearing loss
  • heartburn
  • indigestion
  • lack or loss of strength
  • loss of appetite
  • loss of voice
  • nightmares
  • runny nose
  • sleepiness or unusual drowsiness
  • sneezing
  • stomach discomfort, upset, or pain
  • stuffy nose
  • trouble sleeping
  • weight loss

For Healthcare Professionals

Applies to timolol ophthalmic: ophthalmic gel forming solution, ophthalmic solution


The most commonly reported side effects were burning/stinging sensation, blurred vision, and abnormal vision.


Very common (10% or more): Burning/stinging sensation (up to 38%), blurred/abnormal vision (up to 25%)

Common (1% to 10%): Conjunctival hyperemia, foreign body sensation, keratitis, conjunctivitis, cataract, decreased visual acuity

Frequency not reported: Itching, tearing, redness, blepharitis, dry eyes, decreased corneal sensitivity, corneal erosion, refractive changes (due to withdrawal of miotic therapy in some cases), diplopia, ptosis and choroidal detachment following filtration surgery, discharge (e.g., crusting), foreign body sensation, cystoid macular edema, pseudopemphigoid


Common (1% to 10%): Hypertension

Frequency not reported: Bradycardia, chest pain, arrhythmia, heart block, congestive heart failure, palpitations, cardiac arrest, atrioventricular block, cardiac failure, edema; AV block (second- or third-degree), sino-atrial block, worsening of arterial insufficiency, worsening of angina pectoris, vasodilation, claudication, hypotension, syncope, Raynaud's phenomenon, cold hands and feet


Frequency not reported: Pulmonary edema, bronchospasm (predominantly in patients with pre-existing bronchospastic disease), respiratory failure, dyspnea, cough, rales, sore throat, laryngospasm, respiratory distress

Postmarketing reports: Bronchial obstruction

Nervous system

Common (1% to 10%): Headache

Frequency not reported: Tinnitus, memory loss, diminished concentration, increased dreaming, cerebrovascular accident, cerebral ischemia, dizziness, increase in signs and symptoms of myasthenia gravis, paresthesia, vertigo, local weakness


Frequency not reported: Depression, insomnia, nightmares, catatonia


Frequency not reported: Alopecia, psoriasiform rash or exacerbation of psoriasis, skin rash, sweating, exfoliative dermatitis


Frequency not reported: Nausea, diarrhea, dyspepsia, dry mouth, dysgeusia, abdominal pain, vomiting, mesenteric artery thrombosis, ischemic colitis


Frequency not reported: Systemic lupus erythematosus


Frequency not reported: Anaphylaxis, angioedema, urticaria, localized/generalized rash, anaphylactic reaction

Postmarketing reports: Erythematous rash


Frequency not reported: Decreased libido, Peyronie's disease, impotence, micturition difficulties, retroperitoneal fibrosis


Frequency not reported: Asthenia, fatigue, extremity pain, decreased exercise tolerance, fever


Frequency not reported: Non-thrombocytopenic purpura, thrombocytopenic purpura, agranulocytosis


Frequency not reported: Myalgia, arthralgia


Postmarketing reports: Hepatomegaly


Frequency not reported: Hypoglycemia, hyperglycemia, anorexia

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Istalol (www.drugs.com/istalol.html).