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Isosorbide Mononitrate

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Isosorbide mononitrate Prescription
Generic Name: isosorbide dinitrate (EYE soe SOR bide dye NYE trate)
Brand Name: Dilatrate-SR, Isochron, Isordil, Sorbitrate, isordil titradose, ISDN, Isordil Tembids
Physician reviewed isosorbide dinitrate patient information - includes isosorbide dinitrate description, dosage and directions.

Average Savings for isosorbide mononitrate (generic): 62.21%
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Isosorbide Mononitrate Drug Information:

Isosorbide Dinitrate is a nitrate that dilates (widens) blood vessels, making it easier for blood to flow through them and easier for the heart to pump. Isosorbide Dinitrate is used to treat or prevent attacks of chest pain (angina). Only the sublingual tablet should be used to treat an angina attack that has already begun. Isosorbide Dinitrate regular and extended-release tablets are used to prevent angina attacks but will not treat an angina attack. Isosorbide Dinitrate may also be used for purposes not listed in this medication guide. Learn more

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Isosorbide Mononitrate Side Effects

In Summary

Commonly reported side effects of isosorbide dinitrate include: headache. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to isosorbide dinitrate: capsule extended release, tablet, tablet extended release

Along with its needed effects, isosorbide dinitrate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking isosorbide dinitrate:


  • Bluish-colored lips, fingernails, or palms
  • dark urine
  • difficulty with breathing
  • dizziness or lightheadedness
  • fever
  • headache
  • pale skin
  • rapid heart rate
  • sore throat
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Incidence not known

  • Arm, back, or jaw pain
  • blurred vision
  • chest pain or discomfort
  • chest tightness or heaviness
  • confusion
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fainting
  • fast or irregular heartbeat
  • sweating

Get emergency help immediately if any of the following symptoms of overdose occur while taking isosorbide dinitrate:

Symptoms of overdose

  • Blurred or loss of vision
  • bulging soft spot on the head of an infant
  • change in consciousness
  • change in the ability to see colors, especially blue or yellow
  • cold, clammy skin
  • convulsions
  • disturbed color perception
  • double vision
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling of constant movement of self or surroundings
  • halos around lights
  • headache, severe and throbbing
  • increased sweating
  • loss of appetite
  • loss of consciousness
  • nausea
  • night blindness
  • overbright appearance of lights
  • paralysis
  • sensation of spinning
  • slow heartbeat
  • tunnel vision
  • vomiting

For Healthcare Professionals

Applies to isosorbide dinitrate: oral capsule extended release, oral tablet, oral tablet chewable, oral tablet extended release, sublingual tablet


The most common side effect was headache.

Nervous system

Frequency not reported: Headache, dizziness, syncope, lightheadedness


Common (1% to 10%): Decrease in blood pressure and/or orthostatic hypotension with reflex tachycardia and symptoms/signs of cerebral ischemia (including drowsiness and dizziness and weakness) with first time use and when the dose is increased

Uncommon (0.1% to 1%): Marked decreases in blood pressure with an aggravation of symptomatic angina pectoris, collapse associated with bradycardia and cardiac rhythm disturbances

Frequency not reported: Pallor, crescendo angina, rebound hypertension, hypotension


Common (1% to 10%): Peripheral edema in patients treated for left ventricular failure


Uncommon (0.1% to 1%): Allergic skin reactions

Very rare (less than 0.01%): Exfoliative dermatitis/Stevens-Johnson Syndrome or angioedema

Frequency not reported: Cutaneous vasodilation with flushing, excessive perspiration, rash


Uncommon (0.1% to 1%): Nausea and vomiting

Frequency not reported: Heartburn


Very rare (less than 0.01%): Pituitary apoplexy in patients with undiagnosed pituitary tumors


Very rare (less than 0.01%): Angle closure glaucoma


Very rare (less than 0.01%): Alveolar hypoventilation with consequent hypoxemia and the risk of developing a myocardial infarction in patients with coronary heart disease


Frequency not reported: Methemoglobinemia, hemolytic anemia in patients with glucose-6-phosphate dehydrogenase-deficient syndrome


Frequency not reported: Restlessness

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Isosorbide Mononitrate (www.drugs.com/isosorbide.html).