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Commonly reported side effects of isosorbide dinitrate include: headache. See below for a comprehensive list of adverse effects.
For the ConsumerApplies to isosorbide dinitrate: capsule extended release, tablet, tablet extended release
Along with its needed effects, isosorbide dinitrate may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking isosorbide dinitrate:
Rare
Incidence not known
Get emergency help immediately if any of the following symptoms of overdose occur while taking isosorbide dinitrate:
Symptoms of overdose
For Healthcare Professionals
Applies to isosorbide dinitrate: oral capsule extended release, oral tablet, oral tablet chewable, oral tablet extended release, sublingual tablet
GeneralThe most common side effect was headache.
Nervous systemFrequency not reported: Headache, dizziness, syncope, lightheadedness
CardiovascularCommon (1% to 10%): Decrease in blood pressure and/or orthostatic hypotension with reflex tachycardia and symptoms/signs of cerebral ischemia (including drowsiness and dizziness and weakness) with first time use and when the dose is increased
Uncommon (0.1% to 1%): Marked decreases in blood pressure with an aggravation of symptomatic angina pectoris, collapse associated with bradycardia and cardiac rhythm disturbances
Frequency not reported: Pallor, crescendo angina, rebound hypertension, hypotension
OtherCommon (1% to 10%): Peripheral edema in patients treated for left ventricular failure
DermatologicUncommon (0.1% to 1%): Allergic skin reactions
Very rare (less than 0.01%): Exfoliative dermatitis/Stevens-Johnson Syndrome or angioedema
Frequency not reported: Cutaneous vasodilation with flushing, excessive perspiration, rash
GastrointestinalUncommon (0.1% to 1%): Nausea and vomiting
Frequency not reported: Heartburn
EndocrineVery rare (less than 0.01%): Pituitary apoplexy in patients with undiagnosed pituitary tumors
OcularVery rare (less than 0.01%): Angle closure glaucoma
RespiratoryVery rare (less than 0.01%): Alveolar hypoventilation with consequent hypoxemia and the risk of developing a myocardial infarction in patients with coronary heart disease
HematologicFrequency not reported: Methemoglobinemia, hemolytic anemia in patients with glucose-6-phosphate dehydrogenase-deficient syndrome
PsychiatricFrequency not reported: Restlessness
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Isosorbide Mononitrate (www.drugs.com/isosorbide.html).
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