Generic Name: irinotecan liposomal (EYE ri noe TEE kan LYE poe SOE mal)
Brand Name: Onivyde
What is irinotecan liposomal?
Irinotecan liposomal is a cancer medicine that interferes with the growth and spread of cancer cells in the body.
Irinotecan liposomal is used to treat pancreatic cancer that has spread to other parts of the body.
Irinotecan liposomal is usually given in combination with other cancer medicines.
Irinotecan liposomal may also be used for purposes not listed in this medication guide.
Serious and sometimes fatal infections may occur during treatment with irinotecan liposomal. Seek medical attention right away if you have signs of infection such as: sudden weakness or ill feeling, fever, chills, confusion, shortness of breath, rapid heart rate, and severe dizziness or fainting.
Irinotecan liposomal can cause severe diarrhea, which can be life-threatening if it leads to dehydration. Call your doctor whenever you have diarrhea during your treatment with this medicine.
Before taking this medicine
You should not be treated with this medicine if you are allergic to irinotecan (Onivyde or Camptosar), or if you have:
To make sure irinotecan liposomal is safe for you, tell your doctor if you have:
This medicine can harm an unborn baby or cause birth defects. Do not use if you are pregnant, and tell your doctor right away if you become pregnant. Use effective birth control while you are using this medicine and for at least 1 month after your treatment ends.
A man using irinotecan liposomal should use a condom during treatment, and for at least 4 months after treatment ends.
It is not known whether irinotecan liposomal passes into breast milk or if it could harm a nursing baby. Do not breast-feed while you are using this medicine, and for at least 1 month after your last dose.
How is irinotecan liposomal given?
Irinotecan liposomal is injected into a vein through an IV. A healthcare provider will give you this injection. irinotecan liposomal is usually given once every 2 weeks.
The IV infusion can take at least 90 minutes to complete. Tell your caregivers if you feel any burning, pain, or swelling around the IV needle.
If any of this medicine gets on your skin, wash right away with soap and water.
You may be given medicine to prevent nausea, vomiting, diarrhea, and other side effects.
Irinotecan liposomal can cause severe diarrhea, which can be life-threatening if it leads to dehydration.
Your doctor may recommend you keep anti-diarrhea medicine (such as loperamide or Imodium) on hand at all times. Take the anti-diarrhea medicine at the first sign of loose or frequent bowel movements. Do not take loperamide for longer than 2 full days without your doctor's advice.
Call your doctor whenever you have diarrhea during your treatment with irinotecan liposomal.
Irinotecan liposomal can lower blood cells that help your body fight infections and help your blood to clot. Your blood will need to be tested often. Your cancer treatments may be delayed based on the results of these tests.
If you need surgery, tell the surgeon ahead of time that you are using irinotecan liposomal.
What happens if I miss a dose?
Call your doctor for instructions if you miss an appointment for your irinotecan liposomal injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while receiving irinotecan liposomal?
Avoid using a laxative or stool softener during treatment with irinotecan liposomal.
Avoid being near people who are sick or have infections. Tell your doctor at once if you develop signs of infection.
Irinotecan liposomal may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert.
irinotecan liposomal can pass into body fluids (urine, feces, vomit). For at least 48 hours after you receive a dose, avoid allowing your body fluids to come into contact with your hands or other surfaces. Caregivers should wear rubber gloves while cleaning up a patient's body fluids, handling contaminated trash or laundry or changing diapers. Wash hands before and after removing gloves. Wash soiled clothing and linens separately from other laundry.
Irinotecan liposomal side effects
Get emergency medical help if you have signs of an allergic reaction: hives; chest tightness, wheezing, difficult breathing; swelling of your face, lips, tongue, or throat.
Serious and sometimes fatal infections may occur during treatment with this medicine. Seek medical attention right away if you have signs of infection such as:
sudden weakness or ill feeling, fever, chills, flu-like symptoms;
shallow breathing, rapid heart rate;
swollen gums, painful mouth sores;
skin sores, pale skin, easy bruising;
unusual bleeding; or
confusion, severe dizziness or fainting.
Also call your doctor at once if you have:
severe or ongoing vomiting or diarrhea;
black, bloody, or tarry stools;
a light-headed feeling, like you might pass out;
nausea or vomiting that keeps you from drinking enough fluids;
sudden chest pain or discomfort, wheezing, dry cough, feeling short of breath; or
dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin.
Your cancer treatments may be delayed or permanently discontinued if you have certain side effects.
Common side effects may include:
fever, mouth sores, or other signs of infection;
nausea, vomiting, loss of appetite;
feeling weak or tired; or
temporary hair loss.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Irinotecan liposomal dosing information
Usual Adult Dose for Pancreatic Cancer:
70 mg/m2 IV over 90 minutes every 2 weeks
-This drug should be administered prior to leucovorin and fluorouracil.
-A corticosteroid and an antiemetic should be given 30 minutes prior to administration of this drug.
Use: Indicated in combination with fluorouracil and leucovorin for the treatment of patients with metastatic adenocarcinoma of the pancreas after disease progression following gemcitabine-based therapy.
What other drugs will affect irinotecan liposomal?
Before you are treated with irinotecan liposomal, tell your doctor about all other cancer medicines you have recently used.
Tell your doctor about all your current medicines and any you start or stop using, especially:
St. John's wort;
an antibiotic--clarithromycin, erythromycin, telithromycin;
antifungal medicine--itraconazole, ketoconazole, voriconazole;
antiviral medicine to treat hepatitis or HIV/AIDS--atazanavir, boceprevir, cobicistat (Stribild, Tybost), delavirdine, efavirenz, fosamprenavir, indinavir, nelfinavir, nevirapine, ritonavir, saquinavir, telaprevir;
seizure medicine--carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone; or
tuberculosis medicine--rifabutin, rifapentine, rifampin.
This list is not complete. Other drugs may interact with irinotecan liposomal, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Editorial References and Review
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Irinotecan (www.drugs.com/mtm/irinotecan-liposomal.html).