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Irbesartan is an angiotensin II receptor antagonist. Irbesartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow.
Irbesartan is used to treat high blood pressure (hypertension). It is sometimes given together with other blood pressure medications.
Irbesartan is also used to treat kidney problems caused by type 2 diabetes.
Irbesartan may also be used for purposes not listed in this medication guide.
Do not use if you are pregnant. Stop using and tell your doctor right away if you become pregnant.
If you have diabetes, do not use irbesartan together with any medication that contains aliskiren (a blood pressure medicine).
You should not use irbesartan if you are allergic to it.
If you have diabetes, do not use irbesartan together with any medication that contains aliskiren (a blood pressure medicine).
You may also need to avoid taking irbesartan with aliskiren if you have kidney disease.
Tell your doctor if you have ever had:
kidney disease;
liver disease;
congestive heart failure; or
if you are dehydrated.
Do not use if you are pregnant, and tell your doctor right away if you become pregnant. Irbesartan can cause injury or death to the unborn baby if you take the medicine during your second or third trimester.
You should not breast-feed while using irbesartan.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Irbesartan may be taken with or without food.
Your blood pressure will need to be checked often.
If you are being treated for high blood pressure, keep using this medication even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medication for the rest of your life.
Store at room temperature away from moisture and heat.
Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Drinking alcohol can further lower your blood pressure and may increase certain side effects of irbesartan.
Do not use potassium supplements or salt substitutes, unless your doctor has told you to.
Avoid getting up too fast from a sitting or lying position, or you may feel dizzy.
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
In rare cases, irbesartan can cause a condition that results in the breakdown of skeletal muscle tissue, leading to kidney failure. Call your doctor right away if you have unexplained muscle pain, tenderness, or weakness especially if you also have fever, unusual tiredness, and dark colored urine.
Call your doctor at once if you have:
a light-headed feeling, like you might pass out;
little or no urination;
swelling, rapid weight gain; or
confusion, loss of appetite, vomiting, pain in your side or lower back.
Common side effects may include:
diarrhea;
heartburn, upset stomach; or
tired feeling.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Hypertension:
Initial dose: 150 mg orally once a day
Maximum dose: 300 mg orally once a day
Usual Adult Dose for Diabetic Nephropathy:
Target maintenance dose: 300 mg orally once a day
Use: Treatment of diabetic nephropathy with an elevated serum creatinine and proteinuria (greater than 300 mg/day) in patients with type 2 diabetes and hypertension.
Tell your doctor about all your other medicines, especially:
lithium.
This list is not complete. Other drugs may affect irbesartan, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Irbesartan (www.drugs.com/irbesartan.html).
Commonly reported side effects of irbesartan include: hyperkalemia. See below for a comprehensive list of adverse effects.
Applies to irbesartan: oral tablet
Oral route (Tablet)
When pregnancy is detected, discontinue irbesartan as soon as possible; drugs that act directly on the renin-angiotensin system can cause serious fetal toxicity.
Along with its needed effects, irbesartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking irbesartan:
More common
Less common
Rare
Incidence not known
Some side effects of irbesartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Rare
Incidence not known
Applies to irbesartan: oral tablet
The most common adverse reactions were hyperkalemia, headache, and dizziness.
Hyperkalemia (5.5 mEq/L or greater) occurred in 29.4% of hypertensive diabetic patients with microalbuminuria and normal renal function and in 46.3% of hypertensive diabetic patients with chronic renal insufficiency and overt proteinuria.
Very common (10% or more): Hyperkalemia (up to 46.3%)
Uncommon (0.1% to 1%): Weight gain
Rare (less than 0.1%): Gout, decreased appetite, increased appetite
Frequency not reported: Hyperkalemia
Very common (10% or more): Headache (up to 12.3%), dizziness (up to 10.2%)
Common (1% to 10%): Orthostatic dizziness
Uncommon (0.1% to 1%): Numbness, somnolence, vertigo, paresthesia
Rare (less than 0.1%): Syncope, tremor, coordination disturbance, taste disturbance
Frequency not reported: Tinnitus, dysgeusia, transient ischemic attack, cerebrovascular accident
Common (1% to 10%): Upper respiratory tract infection, sinus abnormality, cough, pharyngitis, rhinitis
Uncommon (0.1% to 1%): Epistaxis, dyspnea
Frequency not reported: Tracheobronchitis, congestion, pulmonary congestion, wheezing
Common (1% to 10%): Nausea/vomiting, diarrhea, dyspepsia/heartburn, abdominal pain
Uncommon (0.1% to 1%): Constipation, flatulence, dry mouth, abdomen distention
Rare (less than 0.1%): Abnormal stool, oral lesion, dysphagia, esophagitis
Frequency not reported: Gastroenteritis
Common (1% to 10%): Fatigue, chest pain, edema
Uncommon (0.1% to 1%): Weakness, malaise, upper extremity edema, extremity swelling, hearing abnormality
Rare (less than 0.1%): Breast disorder, cold sensation, warmth sensation, pain, head/neck edema, medication bad taste
Frequency not reported: Ear pain, ear abnormality, fever, chills, facial edema
Postmarketing reports: Asthenia
Common (1% to 10%): Musculoskeletal pain, musculoskeletal trauma, plasma creatine kinase increased
Uncommon (0.1% to 1%): Muscle cramp
Rare (less than 0.1%): Arthritis, muscle ache, myalgia, extremity weakness, lower extremity stiffness
Frequency not reported: Arthralgia, musculoskeletal chest pain, joint stiffness, bursitis, muscle weakness
Postmarketing reports: Rhabdomyolysis
Common (1% to 10%): Orthostatic hypotension, tachycardia
Uncommon (0.1% to 1%): Flushing, subjective rhythm disturbance, ECG abnormality, cardiac murmur, cardiac rhythm disturbance, atrial rhythm disturbance, bradycardia, hypotension
Rare (less than 0.1%): Conduction disorder, myocardial infarction, hot flashes
Frequency not reported: Hypertension, angina pectoris, arrhythmic disorder, cardiorespiratory arrest, heart failure, hypertensive crisis
Common (1% to 10%): Anxiety/nervousness
Uncommon (0.1% to 1%): Libido change, sleep disturbance, depression, emotion labile/disturbance
Rare (less than 0.1%): Stress related disorder, disturbing dreams
Common (1% to 10%): Rash
Uncommon (0.1% to 1%): Pruritus, facial erythema, hyperhidrosis
Rare (less than 0.1%): Dermatitis, acne, scalp-hair abnormality
Frequency not reported: Angioedema, urticaria, leukocytoclastic vasculitis, ecchymosis
Common (1% to 10%): Urinary tract infection
Uncommon (0.1% to 1%): Sexual dysfunction, urination abnormality
Frequency not reported: Prostate disorder
Common (1% to 10%): Hemoglobin decreased
Uncommon (0.1% to 1%): Neutropenia
Rare (less than 0.1%): Anemia
Postmarketing reports: Thrombocytopenia
Common (1% to 10%): Influenza
Frequency not reported: Hypersensitivity reactions, ear infection
Postmarketing reports: Anaphylactic reaction, anaphylactic shock
Uncommon (0.1% to 1%): BUN increased, serum creatinine increased
Frequency not reported: Impaired renal function, renal failure
Uncommon (0.1% to 1%): Vision disturbance
Rare (less than 0.1%): Eye disturbance, eyelid abnormality, visual field abnormality
Frequency not reported: Conjunctivitis
Uncommon (0.1% to 1%): Jaundice
Frequency not reported: Hepatitis, abnormal liver function
Postmarketing reports: Elevated liver function tests
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Irbesartan (www.drugs.com/irbesartan.html).
June 18, 2020
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