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Iodoquinol

Detailed drug Information for iodoquinol. Includes common brand names, drug descriptions, warnings, side effects and dosing information.
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Drug Information:
In the U.S. Chemical Class: Halogenated Hydroxyquinoline Iodoquinol belongs to the group of medicines called antiprotozoals. These medicines are used to treat infections caused by protozoa (tiny, one-celled animals). Iodoquinol is used most often in the treatment of an intestinal infection called amebiasis. However, it may be used to treat other types of infection as determined by your doctor. Iodoquinol is available only with your doctor's prescription. In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For iodoquinol, the following should be considered: Learn more

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Iodoquinol Side Effects

For the Consumer

Applies to iodoquinol: oral tablets

Side effects include:

Iodism manifested by generalized furunculosis (iodine toxicoderma) and skin reactions (papular and pustular acneiform eruptions, bullae, vegetating or tuberous iododerma), urticaria and pruritus, GI effects (anorexia, nausea, vomiting, diarrhea, abdominal cramps, pruritus ani), fever, chills, headache, vertigo, thyroid enlargement, optic neuritis, optic atrophy, peripheral neuropathy.

For Healthcare Professionals

Applies to iodoquinol: compounding powder, oral tablet

Gastrointestinal

Gastrointestinal side effects have included nausea, vomiting, abdominal cramps, diarrhea, and pruritus ani.

Nervous system

Some neuropathy may be irreversible. Seizures and encephalopathy have been reported in at least one patient. Optic atrophy has been reported, generally in children being treated for acrodermatitis enteropathica at daily dosages between 1300 to 3600 mg for up to two years. Visual deterioration is generally irreversible.

Clioquinol, another hydroxyquinoline, was associated with several thousand cases of subacute myelo-optic neuropathy in Japan, leading to its removal from the market. This syndrome consisted of peripheral weakness, spastic paraparesis, dysesthesia, and optic neuropathy.

Because of the neurotoxicity associated with iodoquinol and its growing use in pediatric patients for the treatment of nonspecific chronic diarrhea in the 1970's, the American Academy of Pediatrics Committee on Drugs issued a statement recommending that products containing clioquinol or iodoquinol not be used in pediatric patients.

Nervous system side effects have been reported rarely. These have included peripheral neuropathy and headache. Optic atrophy has been reported, generally in pediatric patients receiving large doses for long periods of time.

Dermatologic

Dermatologic side effects have included acneiform papular or pustular skin eruptions, bulla, urticaria, and pruritus. These reactions are related to the iodine content of iodoquinol.

Other

Other side effects have included fever, chills, and enlargement of the thyroid.

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Iodoquinol (www.drugs.com/cons/iodoquinol.html).