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Intralipid

Generic Name: Fat Emulsion (Plant Based) (fat e MUL shun plant baste)
Brand Name: Clinolipid, Intralipid, Nutrilipid
Easy-to-read patient leaflet for Intralipid. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Drug Information:
This is not a list of all drugs or health problems that interact with Intralipid (fat emulsion (plant based)). Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Intralipid (fat emulsion (plant based)) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Use Intralipid (fat emulsion (plant based)) as ordered by your doctor. Read all information given to you. Follow all instructions closely. Learn more

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Intralipid Side Effects

Note: This document contains side effect information about fat emulsion. Some of the dosage forms listed on this page may not apply to the brand name Intralipid.

For the Consumer

Applies to fat emulsion: intravenous emulsion

Warning

Intravenous route (Emulsion)

Deaths due to intravascular fat accumulation in the lungs in preterm infants after infusion of intravenous fat emulsion have been reported in the medical literature. Autopsy findings included intravascular fat accumulation in the lungs. Preterm infants and low-birth-weight infants have poor clearance of intravenous lipid emulsion and increased free fatty acid plasma levels following lipid emulsion infusion. Use caution when treating premature and low birth weight infants with intravenous fat emulsion and strictly adhere to the recommended total daily dose and hourly infusion rates. Hourly infusion rate should be as slow as possible in each case and fat should not in any case exceed 1 g fat/kg in four hours. Carefully monitor serum triglycerides and/or plasma free fatty acid levels in these patients..

Along with its needed effects, fat emulsion (the active ingredient contained in Intralipid) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking fat emulsion:

More common

  • Accumulation of pus
  • black, tarry stools
  • bladder pain
  • bloody or cloudy urine
  • bluish lips or skin
  • chest pain or discomfort
  • chills
  • cough
  • diarrhea
  • difficult, burning, or painful urination
  • excessive muscle tone
  • fever
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • headache
  • hoarseness
  • joint pain
  • lightheadedness, dizziness, or fainting
  • loss of appetite
  • lower back or side pain
  • muscle aches and pains
  • muscle stiffness, tension, or tightness
  • nausea
  • pale skin
  • runny nose
  • shivering
  • slow or irregular heartbeat
  • sore throat
  • sweating
  • swollen, red, tender area of infection
  • trouble sleeping
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • vomiting

Rare

  • Back pain
  • fast heartbeat
  • hives

Incidence not known

  • Bleeding gums
  • changes in skin color
  • changes in urination
  • coughing up blood
  • difficulty in breathing or swallowing
  • fruit-like breath odor
  • increased menstrual flow or vaginal bleeding
  • increased thirst
  • nosebleed
  • paralysis
  • prolonged bleeding from cuts
  • rash
  • red or dark brown urine
  • red or black, tarry stools
  • stomach pain
  • swelling and redness in the lower leg

Some side effects of fat emulsion may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Agitation
  • redness of the skin
  • redness, swelling, or pain at the injection site

Less common

  • Itchy skin

For Healthcare Professionals

Applies to fat emulsion: intravenous emulsion

Hepatic

Common (1% to 10%): Cholestasis, blood bilirubin increased

Uncommon (0.1% to 1%): Cytolytic hepatitis, cholecystitis, cholelithiasis, liver function test abnormalities, pancreatic enzyme increased

Frequency not reported: Increased gamma-glutamyltransferase, hepatomegaly, jaundice due to central lobular cholestasis, transient increases in liver function tests

Hematologic

Common (1% to 10%): Anemia

Uncommon (0.1% to 1%): Leukopenia

Rare (less than 0.1%): Thrombocytopenia in neonates

Frequency not reported: Leukocytosis, hypercoagulability, splenomegaly, thrombocytopenia

Cardiovascular

Common (1% to 10%): Hypertension, mean arterial pressure decreased

Uncommon (0.1% to 1%): Circulatory collapse, hypotension, hot flush

Frequency not reported: Tachycardia, thrombophlebitis, cyanosis, flushing, arrhythmia

Hypersensitivity

Frequency not reported: Allergic reaction, hypersensitivity

Immunologic

Common (1% to 10%): Sepsis, device related infection

Frequency not reported: Pneumonia, infection, septicemia

Other

Common (1% to 10%): Pyrexia

Frequency not reported: Increased blood alkaline phosphatase, increased C-reactive protein, increase in temperature, pain in chest and back, slight pressure over the eyes, overloading syndrome (focal seizures, fever, leukocytosis, hepatomegaly, splenomegaly, and shock), intravenous fat pigment (deposition of brown pigmentation in the reticuloendothelial system), increased blood level of immunosuppressant drug, asthenia, malaise

Postmarketing reports: International normalized ration decreased

Nervous system

Frequency not reported: Dysgeusia, headache, dizziness, sleepiness, cerebral edema, convulsion

Musculoskeletal

Common (1% to 10%): Muscle spasms

Uncommon (0.1% to 1%): Back pain, chills

Frequency not reported: Bone necrosis

Respiratory

Frequency not reported: Respiratory insufficiency

Gastrointestinal

Common (1% to 10%): Nausea, vomiting, flatulence, abdominal pain, dyspepsia, abdominal distension, epigastric discomfort

Frequency not reported: Diarrhea

Dermatologic

Frequency not reported: Pruritus, rash, sweating

Genitourinary

Common (1% to 10%): Urinary tract infection

Local

Frequency not reported: Irritation at sight of infusion

Metabolic

Common (1% to 10%): Hyperglycemia, blood triglycerides increased, hyperproteinemia, hyperlipidemia

Frequency not reported: Hyperlipemia, diabetes mellitus inadequate control, hypoproteinemia

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Intralipid (www.drugs.com/cdi/intralipid.html).