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Injectafer

Generic Name: ferric carboxymaltose (FER ik kar BOX ee MAWL tose)
Brand Names: Injectafer
Injectafer (ferric carboxymaltose) is an iron replacement injection used to treat iron deficiency anemia. Includes Injectafer side effects, interactions and indications.
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Drug Information:
Injectafer (ferric carboxymaltose) is an iron replacement product. You normally get iron from the foods you eat. Iron helps your body produce red blood cells that carry oxygen through your blood to tissues and organs. Injectafer is used in adults to treat iron deficiency anemia (a lack of red blood cells caused by having too little iron in the body). Injectafer is usually given after oral (taken by mouth) iron replacement medicines have been tried without success. You should not use Injectafer if you have iron overload disorder, or anemia that is not caused by iron deficiency. Learn more

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Injectafer Side Effects

Note: This document contains side effect information about ferric carboxymaltose. Some of the dosage forms listed on this page may not apply to the brand name Injectafer.

For the Consumer

Applies to ferric carboxymaltose: intravenous solution

Along with its needed effects, ferric carboxymaltose (the active ingredient contained in Injectafer) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking ferric carboxymaltose:

Less common

  • Blurred vision
  • confusion
  • dizziness
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • feeling of warmth
  • headache
  • nervousness
  • pounding in the ears
  • redness of the face, neck, arms, and occasionally, upper chest
  • slow or fast heartbeat
  • sweating
  • unusual tiredness or weakness

Incidence not known

  • Chest discomfort
  • chills
  • cough
  • difficult or labored breathing
  • difficulty swallowing
  • fainting
  • fast, pounding, or irregular heartbeat or pulse
  • fever
  • hives
  • itching
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • skin rash
  • tightness in the chest

Some side effects of ferric carboxymaltose may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Nausea

Less common

  • Change in taste
  • discoloration at the injection site
  • loss of taste
  • vomiting

Rare

  • Abdominal or stomach pain
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • diarrhea
  • difficulty having a bowel movement (stool)
  • pain or irritation at the injection site
  • sneezing

Incidence not known

  • Back pain
  • difficulty with moving
  • hives or welts
  • muscle pain or stiffness
  • pain in the joints
  • redness of the skin

For Healthcare Professionals

Applies to ferric carboxymaltose: intravenous solution

Cardiovascular

Common (1% to 10%): Flushing/hot flush, hypertension, hypotension

Uncommon (0.1% to 1%): Chest pain, peripheral edema, tachycardia

Rare (less than 0.1%): Phlebitis

Postmarketing reports: Chest discomfort, pallor

Dermatologic

Uncommon (0.1% to 1%): Erythema, rash, pruritus, urticaria

Postmarketing reports: Angioedema, dermatitis

Gastrointestinal

Common (1% to 10%): Nausea, vomiting

Uncommon (0.1% to 1%): Abdominal pain, constipation, diarrhea, dyspepsia

Rare (less than 0.1%): Flatulence

Hepatic

Common (1% to 10%): Alanine aminotransferase increase

Uncommon (0.1% to 1%): Aspartate aminotransferase increase, gamma glutamyl transferase increase

Hypersensitivity

Common (1% to 10%): Pruritus, rash, urticaria, wheezing, and hypertension associated with hypersensitivity reactions

Rare (less than 0.1%): Serious anaphylactic/anaphylactoid reactions

Local

Common (1% to 10%): Injection site reactions

Injection site reactions include infusion site burning, -pain, -bruising, -discoloration, -extravasation, -irritation, and -paresthesia.

Metabolic

Common (1% to 10%): Blood phosphorus decrease, hypophosphatemia

Uncommon (0.1% to 1%): Blood alkaline phosphatase increase, blood lactate dehydrogenase increase

Musculoskeletal

Postmarketing reports: Arthralgia, back pain, hypophosphatemic osteomalacia, muscle spasms, myalgia

Nervous system

Common (1% to 10%): Dizziness, dysgeusia, headache

Uncommon (0.1% to 1%): Paraesthesia

Rare (less than 0.1%): Syncope, presyncope

Postmarketing reports: Loss of consciousness

Other

Uncommon (0.1% to 1%): Chills, fatigue, pain, pyrexia

Rare (less than 0.1%): Malaise, rigors

Frequency not reported: Overestimate of serum iron and transferrin bound iron laboratory assays

Postmarketing reports: Face edema, vertigo

Respiratory

Uncommon (0.1% to 1%): Sneezing

Rare (less than 0.1%): Bronchospasm

Postmarketing reports: Dyspnea

Psychiatric

Rare (less than 0.1%): Anxiety

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Injectafer (www.drugs.com/injectafer.html).