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Indapamide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.
Indapamide treats fluid retention (edema) in people with congestive heart failure. indapamide is also used to treat high blood pressure (hypertension).
Indapamide may also be used for purposes not listed in this medication guide.
You should not use this medicine if you are allergic to sulfa drugs or if you are unable to urinate.
You should not use indapamide if you are allergic to it, or if:
you are unable to urinate; or
you are allergic to sulfa drugs.
To make sure indapamide is safe for you, tell your doctor if you have:
cirrhosis or other liver disease;
kidney disease;
low levels of potassium or sodium in your blood;
gout;
diabetes;
lupus; or
if you are on a low-salt diet.
Indapamide is not expected to be harmful to an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It is not known whether indapamide passes into breast milk or if it could harm a nursing baby. You should not breast-feed while using indapamide.
Indapamide is not approved for use by anyone younger than 18 years old.
Follow all directions on your prescription label. Your doctor may occasionally change your dose to make sure you get the best results. Do not use this medicine in larger or smaller amounts or for longer than recommended.
Indapamide is usually taken once per day in the morning. Follow your doctor's dosing instructions very carefully.
Call your doctor if you have ongoing vomiting or diarrhea, or if you are sweating more than usual. You can easily become dehydrated while taking this medicine, which can lead to severely low blood pressure or a serious electrolyte imbalance.
While using indapamide, you may need frequent medical tests and blood pressure checks. Your blood and urine may both be tested if you have been vomiting or are dehydrated.
If you are being treated for high blood pressure, keep using this medicine even if you feel well. High blood pressure often has no symptoms. You may need to use blood pressure medicine for the rest of your life.
Store at room temperature away from moisture, heat, and light. Keep the bottle tightly closed when not in use.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
Overdose symptoms may include vomiting, weakness, dizziness, dry mouth, thirst, and muscle pain or weakness.
Avoid becoming overheated or dehydrated during exercise, in hot weather, or by not drinking enough fluids. Follow your doctor's instructions about the type and amount of liquids you should drink. In some cases, drinking too much liquid can be as unsafe as not drinking enough.
Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have signs of an electrolyte imbalance, such as:
drowsiness, lack of energy, feeling tired;
leg cramps, muscle weakness or limp feeling;
severe weakness, loss of coordination, feeling unsteady;
fast or irregular heartbeats, fluttering in your chest, feeling restless;
numbness or tingling;
vomiting, constipation;
headache, confusion, slurred speech;
a light-headed feeling, like you might pass out;
dry mouth, increased thirst; or
little or no urinating.
Common side effects may include:
dizziness;
weakness, tiredness;
back pain, muscle cramps;
feeling anxious or agitated;
headache; or
runny nose.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Edema:
Initial dose: 2.5 mg orally once a day.
Usual Adult Dose for Hypertension:
Initial dose: 1.25 mg orally once a day.
Tell your doctor about all your current medicines and any you start or stop using, especially:
digoxin, digitalis;
lithium;
blood pressure medication; or
steroids (prednisone and others).
This list is not complete. Other drugs may interact with indapamide, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed in this medication guide.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Indapamide (www.drugs.com/mtm/indapamide.html).
Commonly reported side effects of indapamide include: hypokalemia. See below for a comprehensive list of adverse effects.
Applies to indapamide: oral tablet
Along with its needed effects, indapamide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor as soon as possible if any of the following side effects occur while taking indapamide:
Signs and symptoms of an imbalance of water or potassium in the body
Rare
Some side effects of indapamide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common or rare
Applies to indapamide: compounding powder, oral tablet
Most adverse side effects are mild and transient.
Dermatologic reactions, such as rashes, occur in less than 5% of patients, and comprise up to 36% of all adverse drug reactions associated with indapamide.
Metabolic abnormalities are common, but are rarely clinically significant. Hypokalemia occurs in 15% of patients, although clinically relevant hypokalemia is reported in only 1% and 3% of patients receiving 2.5 and 5.0 mg/day, respectively. Hyponatremia, hyperglycemia, and hyperuricemia are reported in 1% to 5% of patients but are rarely clinically relevant. Unlike the thiazides, indapamide has little or no adverse effect on the lipid profile. Severe cases of hyponatremia, accompanied by hypokalemia have been reported with recommended doses of indapamide in elderly females.
Renal side effects are unusual, consisting primarily of azotemia.
A case of interstitial nephritis and an urticarial rash associated with indapamide has been reported.
Gastrointestinal side effects include dyspepsia, constipation, diarrhea, flatulence, and dry mouth in less than 5% of patients.
Nervous system side effects include dizziness, lightheadedness, headache, and fatigue in 5% of patients.
Cardiovascular side effects are usually limited to postural hypotension. Indapamide does not affect the heart rate.
Musculoskeletal cramps are reported in about 5% of patients. A single case of skeletal muscle damage has been associated with indapamide.
A 71-year-old woman with a history of psychiatric problems and reflux esophagitis developed chest pain, finger numbness, sweating, and nausea while gardening. Her medications included indapamide, trifluoperazine, oxazepam, and ranitidine. Myocardial infarction was definitively ruled out by ECG and CPK isoenzyme analysis. Interesting laboratory values included a reduced serum sodium (117 mmol/L), elevated LDH and AST enzymes, and elevated CPK-MM isoenzymes. There was no history of muscular trauma, and thyroid function tests were normal. The hyponatremia and elevated CPK-MM fractions fell precipitously upon hydration with normal saline. A definite causal link between indapamide and rhabdomyolysis could not be made, but thiazide diuretics have been previously implicated in some cases of hypokalemia with subsequent muscle damage.
Genitourinary side effects generally reflect the activity of the drug, with less than 5% of patients reporting polyuria and nocturia.
Decreased sexual libido is rare, with up to 88% of patients reporting no change and most of the remaining 12% reporting improvement of sexual libido during indapamide therapy.
A case of reversible hepatitis associated with indapamide has been reported.
Hepatic side effects are rare, at least one case of hepatitis has been reported.
Hypersensitivity reactions occur in less than 5% of patients. Cases of severe reactions including toxic epidermal necrolysis, erythema multiforme, and Stevens-Johnson syndrome have been reported. Patients with a sulfa allergy may react to indapamide.
Endocrine side effects include at least one case of indapamide-induced hyperparathyroidism. In one study, indapamide significantly reduced parathyroid hormone levels in all patients.
Hematologic side effects are rare, but have included at least one case of mild thrombocytopenia and mucosal bleeding from the tongue. Bleeding stopped promptly and platelet counts returned to normal following discontinuation of indapamide.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Indapamide (www.drugs.com/mtm/indapamide.html).
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