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Generic Name: canakinumab (KAN a KIN ue mab)
Brand Names: Ilaris
Ilaris is used to treat rare genetic conditions such as Familial Cold Autoinflammatory Syndrome. Learn about side effects, interactions and indications.
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Drug Information:
Ilaris (canakinumab) is a monoclonal antibody that blocks certain proteins in the body that can affect inflammation and other immune responses. Ilaris is used to treat certain types of periodic fever syndromes, sometimes called auto-inflammatory syndromes. Periodic fever syndromes are rare and often inherited conditions caused by mutations in certain genes; usually genes that are involved in producing a certain protein or enzyme in the body. People with a periodic fever syndrome have episodes of fever and inflammation without other causes such as infection or virus. Learn more

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Ilaris Side Effects

Note: This document contains side effect information about canakinumab. Some of the dosage forms listed on this page may not apply to the brand name Ilaris.

For the Consumer

Applies to canakinumab: subcutaneous solution

Along with its needed effects, canakinumab (the active ingredient contained in Ilaris) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking canakinumab:

More common

  • Body aches or pain
  • chills
  • congestion
  • cough
  • diarrhea
  • dryness or soreness of the throat
  • fever
  • headache
  • hoarseness
  • joint pain
  • loss of appetite
  • muscle aches and pains
  • nausea
  • shivering
  • shortness of breath
  • sneezing
  • stuffy or runny nose
  • sweating
  • tender, swollen glands in the neck
  • tightness in the chest
  • trouble sleeping
  • trouble swallowing
  • unusual tiredness or weakness
  • voice changes
  • vomiting

Some side effects of canakinumab may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Abdominal or stomach pain
  • bleeding, blistering, burning, coldness, discoloration of the skin, feeling of pressure, hives, infection, inflammation, itching, lumps, numbness, pain, rash, redness, scarring, soreness, stinging, swelling, tenderness, tingling, ulceration, or warmth at the injection site
  • dizziness or lightheadedness
  • feeling of constant movement of self or surroundings
  • increased weight
  • muscle or bone pain
  • sensation of spinning
  • weakness

For Healthcare Professionals

Applies to canakinumab: subcutaneous powder for injection, subcutaneous solution


Very common (10% or more): Diarrhea (20%), nausea (14%), gastroenteritis, tonsillitis, upper abdominal pain, gastroesophageal reflux disease


Very common (10% or more): Urinary tract infection


Very common (10% or more): Leukopenia

Frequency not reported: Hemoglobin increased, decreased white blood cells, decreased neutrophils, decreased platelets


Rare (less than 0.1%): Elevated transaminases

Frequency not reported: Elevated serum bilirubin


Frequency not reported: Hypersensitivity reactions (unspecified)


Very common (10% or more): Influenza (17%), viral infection (13%)


Very common (10% or more): Injection site reaction


Very common (10% or more): Musculoskeletal pain (11%), arthralgia

Common (1% to 10%): Back pain

Nervous system

Very common (10% or more): Headache (14%), dizziness/vertigo (11%)


Very common (10% or more): Ear infection

Common (1% to 10%): Fatigue/asthenia


Very common (10% or more): Nasopharyngitis (34%), rhinitis (17%), bronchitis (11%), pneumonia, sinusitis, rhinitis, pharyngitis, upper respiratory tract infection


Very common (10% or more): Cellulitis


Very common (10% or more): Weight gain (11%)


Very common (10% or more): Creatinine clearance decreased, proteinuria

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Ilaris (www.drugs.com/ilaris.html).