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Ibrance Prescription
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Generic Name: palbociclib (PAL boe SYE klib)
Brand Names: Ibrance
Ibrance (palbociclib) is used to treat metastatic breast cancer. Includes Ibrance side effects, interactions and indications.
Generic Name: palbociclib (PAL boe SYE klib)
Brand Names: Ibrance
Ibrance (palbociclib) is used to treat metastatic breast cancer. Includes Ibrance side effects, interactions and indications.
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3 tablets of Ibrance 40 mg
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Ibrance Drug Information:

Ibrance (palbociclib) is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Ibrance is used in men and women to treat HR-positive, HER2-negative breast cancer that has spread to other parts of the body. In postmenopausal women, Ibrance is given in combination with a hormonal medicine such as Letrozole (Femara). In others, Ibrance is given together with Fulvestrant (Faslodex). Ibrance affects your immune system. You may get infections more easily, even serious or fatal infections. Call your doctor if you have a fever, chills, cough, mouth sores, or unusual bleeding or bruising. Learn more

Ibrance Side Effects

Note: This document contains side effect information about palbociclib. Some of the dosage forms listed on this page may not apply to the brand name Ibrance.

In Summary

Common side effects of Ibrance include: decreased neutrophils. Other side effects include: infection and pulmonary embolism. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to palbociclib: capsule oral, oral capsule

Along with its needed effects, palbociclib (the active ingredient contained in Ibrance) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking palbociclib:

More common

  • Black, tarry stools
  • body aches or pain
  • chills
  • cough
  • ear congestion
  • fever
  • headache
  • loss of voice
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • sneezing
  • sore throat
  • stuffy or runny nose
  • swelling or inflammation of the mouth
  • trouble breathing
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common

  • Anxiety
  • bloody nose
  • chest pain
  • dizziness or lightheadedness
  • fainting
  • fast heartbeat
  • hoarseness
  • sudden shortness of breath or troubled breathing

Some side effects of palbociclib may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • hair loss or thinning of the hair
  • lack or loss of strength
  • nausea
  • vomiting

Less common

  • Burning, numbness, tingling, or painful sensation
  • decreased appetite
  • unsteadiness or awkwardness
  • weakness in the arms, legs, or feet

For Healthcare Professionals

Applies to palbociclib: oral capsule


Very common (10% or more): Decreased white blood cells (95%), decreased neutrophils (94%), decreased hemoglobin (83%), decreased lymphocytes (81%), neutropenia (80%), decreased platelets (61%), leukopenia (39%), anemia (24%), thrombocytopenia (16%)

Frequency not reported: Febrile neutropenia


Very common (10% or more): Upper respiratory infection (up to 31%), epistaxis (up to 11%)

Common (1% to 10%): Pulmonary embolism


Very common (10% or more): Fatigue (37%), asthenia (17%), pyrexia (12%)


Most common adverse reactions (10% or greater incidence): Neutropenia, leukopenia, fatigue, anemia, infections, nausea, stomatitis, alopecia, diarrhea, thrombocytopenia, decreased appetite, vomiting, asthenia, peripheral neuropathy, and epistaxis.


Very common (10% or more): Nausea (35%), stomatitis (30%), diarrhea (26%), vomiting (16%)


Very common (10% or more): Alopecia (33%), rash (18%), dry skin (12%)


Very common (10% or more): Decreased appetite (16%)

Nervous system

Very common (10% or more): Peripheral neuropathy (13%), dysgeusia (10%)


Very common (10% or more): Infections (e.g., nasopharyngitis, upper respiratory tract infection, urinary tract infection, oral herpes, sinusitis, rhinitis, bronchitis, influenza, pneumonia, gastroenteritis, conjunctivitis, herpes zoster, pharyngitis, cellulitis, cystitis, lower respiratory tract infection, tooth infection, gingivitis, skin infection, gastroenteritis viral, respiratory tract infection, respiratory tract infection viral, folliculitis) (60%)

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Ibrance (www.drugs.com/ibrance.html).