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Hyzaar Prescription
Generic Name: hydrochlorothiazide and losartan (HYE droe KLOR oh THYE a zide and loe SAR tan)
Brand Names: Hyzaar
Hyzaar (hydrochlorothiazide and losartan) is used to treat high blood pressure and to reduce the risk of stroke in people with hypertension. Includes Hyzaar side effects, interactions and indications.

Average Savings for losartan potassium/hydroc (generic): 59.49%
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Hyzaar Drug Information:

Hyzaar contains a combination of hydroChlorothiazide and losartan. HydroChlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention. Losartan is an angiotensin II receptor antagonist (sometimes called an ARB blocker). Losartan keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Hyzaar is used to treat high blood pressure (hypertension). Hyzaar is also used to lower the risk of stroke in certain people with heart disease. Learn more

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Hyzaar Side Effects

Note: This document contains side effect information about hydrochlorothiazide / losartan. Some of the dosage forms listed on this page may not apply to the brand name Hyzaar.

In Summary

More frequent side effects include: dizziness. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to hydrochlorothiazide / losartan: oral tablet


Oral route (Tablet)

Drugs that act directly on the renin-angiotensin system can cause injury or death to the developing fetus. Stop therapy as soon as possible when pregnancy is detected.

Along with its needed effects, hydrochlorothiazide/losartan may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydrochlorothiazide / losartan:


  • Black, tarry stools
  • blood in the urine or stools
  • cough or hoarseness accompanied by chills or fever, lower back or side pain, or painful or difficult urination
  • fainting
  • pinpoint red spots on the skin
  • pounding heartbeat
  • severe stomach pain, nausea, and vomiting
  • skin rash
  • swelling of the feet or lower legs
  • unusual bleeding or bruising

Incidence not known

  • Coma
  • confusion
  • dark-colored urine
  • decreased urine output
  • dry mouth
  • fast or irregular heartbeat
  • fever
  • increased thirst
  • irritability
  • large, flat, blue, or purplish patches in the skin
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • light-colored stools
  • muscle cramps or pain
  • muscle spasms
  • muscle stiffness
  • muscle twitching
  • nausea or vomiting
  • painful knees and ankles
  • raised red swellings on the skin, the buttocks, legs, or ankles
  • restlessness
  • seizures
  • shortness of breath
  • swelling of the face, ankles, or hands
  • upper right abdominal or stomach pain
  • unusual tiredness or weakness
  • weak or irregular heartbeat
  • yellow eyes and skin

Some side effects of hydrochlorothiazide / losartan may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Cold or flu-like symptoms
  • dizziness
  • headache
  • increased sensitivity of the skin to sunlight
  • sore throat
  • stomach pain


  • Dry cough
  • sinus problems

For Healthcare Professionals

Applies to hydrochlorothiazide / losartan: oral tablet


The most common adverse reaction was dizziness.

Nervous system

Common (1% to 10%): Dizziness, headache


Frequency not reported: Syncope, cerebrovascular accident, ataxia, hypesthesia, memory impairment, migraine, paresthesia, peripheral neuropathy, somnolence, vertigo, tremor, taste perversion, tinnitus


Common (1% to 10%): Cough, sinusitis, upper respiratory infection, bronchitis, pharyngitis


Frequency not reported: Respiratory distress, pneumonitis, pulmonary edema


Frequency not reported: Dyspnea, epistaxis, nasal congestion, pharyngeal discomfort, respiratory congestion, rhinitis, sinus disorder

Postmarketing reports: Dry cough


Common (1% to 10%): Abdominal pain, diarrhea, nausea


Frequency not reported: Pancreatitis, sialadenitis, cramping, gastric irritation


Frequency not reported: Constipation, dental pain, dry mouth, dyspepsia, flatulence, gastritis, vomiting


Common (1% to 10%): Palpitation, essential hypertension

Uncommon (0.1% to 1%): Hypotension


Frequency not reported: Vasculitis


Frequency not reported: Angina pectoris, arrhythmias, atrial fibrillation, sinus bradycardia, tachycardia, ventricular tachycardia, ventricular fibrillation, hypotension, myocardial infarction, second degree atrioventricular block, flushing

Postmarketing reports: Vasculitis


Common (1% to 10%): Edema/swelling, asthenia/fatigue


Frequency not reported: Weakness, fever


Frequency not reported: Chest pain, facial edema, fever, orthostatic effects, malaise


Common (1% to 10%): Rash


Frequency not reported: Purpura, photosensitivity, urticaria, cutaneous vasculitis, erythema multiforme, Stevens-Johnson syndrome, exfoliative dermatitis, toxic epidermal necrolysis


Common (1% to 10%): Rash

Frequency not reported: Angioedema, superficial peeling of palms, alopecia, dermatitis, dry skin, ecchymosis, erythema, photosensitivity, pruritus, sweating, urticaria

Postmarketing reports: Erythroderma


Common (1% to 10%): Back pain


Frequency not reported: Muscle spasm


Frequency not reported: Arm pain, arthralgia, arthritis, fibromyalgia, hip pain, joint swelling, knee pain, leg pain, muscle cramps, muscle weakness, musculoskeletal pain, myalgia, shoulder pain, stiffness

Postmarketing reports: Rhabdomyolysis


Uncommon (0.1% to 1%): Serum creatinine increased greater than 5 mg/dL, BUN increased


Frequency not reported: Renal failure, renal dysfunction, interstitial nephritis


Common (1% to 10%): Serum creatinine increased greater than 5 mg/dL


Frequency not reported: Liver enzymes elevated, serum bilirubin elevated

Postmarketing reports: Hepatitis


Frequency not reported: Intrahepatic cholestatic jaundice


Postmarketing reports: Hepatitis


Frequency not reported: Hemoglobin decreased, hematocrit decreased


Frequency not reported: Aplastic anemia, agranulocytosis, leukopenia, hemolytic anemia, thrombocytopenia


Frequency not reported: Hemolysis, anemia


Postmarketing reports: Hyperkalemia


Frequency not reported: Hyperglycemia, hyperuricemia


Frequency not reported: Anorexia, gout

Postmarketing reports: Hyperkalemia, hyponatremia



Frequency not reported: Transient blurred vision, xanthopsia


Frequency not reported: Blurred vision, burning/stinging in the eye, conjunctivitis, visual acuity decreased



Frequency not reported: Restlessness


Frequency not reported: Anxiety, anxiety disorder, confusion, dream abnormality, depression, insomnia, libido decreased, nervousness, panic disorder, sleep disorder



Frequency not reported: Glycosuria


Frequency not reported: Impotence, nocturia, urinary frequency, urinary tract infection



Postmarketing reports: Anaphylactic reactions

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Hyzaar (www.drugs.com/hyzaar.html).