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Hydroxyurea

Hydroxyurea Prescription
Generic Name: hydroxyurea (hye DROX ee yoo REE a)
Brand Name: Droxia, Hydrea, Mylocel, Siklos
Physician reviewed hydroxyurea patient information - includes hydroxyurea description, dosage and directions.

Average Savings for hydroxyurea (generic): 48.4%
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Hydroxyurea Drug Information:

HydroxyUrea is used to treat chronic myeloid leukemia, ovarian cancer, and certain types of skin cancer (squamous cell cancer of the head and neck). HydroxyUrea is also used to reduce pain episodes and the need for blood transfusions in people with sickle cell anemia. HydroxyUrea will not cure sickle cell anemia. HydroxyUrea may also be used for purposes not listed in this medication guide. Both men and women using hydroxyUrea should use birth control to prevent pregnancy. The use of hydroxyUrea by either parent may cause birth defects. Learn more

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Hydroxyurea Side Effects

For the Consumer

Applies to hydroxyurea: oral capsule, oral tablet

Warning

Oral route (Tablet)

Myelosuppression and MalignanciesMyelosuppression: Hydroxyurea oral tablets may cause severe myelosuppression. Monitor blood counts at baseline and throughout treatment. Interrupt treatment and reduce dose as necessary.Malignancies: Hydroxyurea is carcinogenic. Advise sun protection and monitor patients for malignancies.

Oral route (Capsule)

Hydroxyurea may cause severe myelosuppression. Monitor blood counts at baseline and throughout treatment. Interrupt treatment and reduce dose as necessary. Hydroxyurea is carcinogenic. Advise sun protection and monitor patients for malignancy.

Along with its needed effects, hydroxyurea may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydroxyurea:

More common

  • Chills
  • cough
  • fever
  • hoarseness
  • lower back or side pain
  • painful or difficult urination

Less common

  • Black, tarry stools
  • blackening of the fingernails and toenails
  • blood in the urine or stools
  • pinpoint red spots on the skin
  • sores in the mouth and on the lips
  • unusual bleeding or bruising

Rare

  • Confusion
  • dizziness
  • headache
  • joint pain
  • seeing, hearing, or feeling things that are not there
  • seizures
  • swelling of the feet or lower legs

Incidence not known

  • Bleeding under the skin
  • blisters on the skin
  • bluish or pale color on the skin of the fingers or toes
  • coldness of the fingers or toes
  • crater-like lesions on the skin
  • fast heartbeat
  • hives, itching, skin rash
  • irritation
  • joint pain, stiffness, or swelling
  • numbness or tingling of the fingers or toes
  • pain in the fingers or toes
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled breathing or swallowing
  • unusual tiredness or weakness
  • weight loss

Some side effects of hydroxyurea may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • drowsiness
  • loss of appetite
  • nausea
  • vomiting

Less common

  • Constipation
  • redness of skin at the place of radiation
  • skin rash and itching

Incidence not known

  • Bluish-brownish bands on the nails

For Healthcare Professionals

Applies to hydroxyurea: compounding powder, oral capsule, oral tablet

Hematologic

Very common (10% or more): Bone marrow failure, CD4 lymphocytes decreased, leukopenia, thrombocytopenia, platelet count decreased, anemia

Common (1% to 10%): Neutropenia

Gastrointestinal

Very common (10% or more): Pancreatitis, nausea, vomiting, diarrhea, stomatitis, constipation, mucositis, stomach discomfort, dyspepsia, abdominal pain, melena

Other

Very common (10% or more): Pyrexia, asthenia, chills, malaise, fever, edema

Dermatologic

Very common (10% or more): Cutaneous vasculitis, dermatomyositis, alopecia, maculopapular rash, papular rash, skin exfoliation, skin atrophy, skin ulcer, erythema, skin hyperpigmentation, nail disorder

Very rare (less than 0.01%): Transverse melanonychia

Frequency not reported: Squamous dysplasia, facial erythema

Oncologic

Common (1% to 10%): Skin cancers, neoplasms benign and malignant [including cysts and polyps])

Frequency not reported: This drug has been shown to be mutagenic, clastogenic, and cause cellular transformation to a tumorigenic phenotype. This drug has been reported to be unequivocally genotoxic and a presumed transspecies carcinogen, which implies a carcinogenic risk to humans.

Genitourinary

Very common (10% or more): Azoospermia, oligospermia

Very rare (less than 0.01%): Dysuria

Nervous system

Common (1% to 10%): Convulsion, dizziness, peripheral neuropathy, drowsiness

Frequency not reported: Severe peripheral neuropathy has been reported in HIV-infected patients who received this drug in combination with antiretroviral drugs

Hepatic

Common (1% to 10%): Hepatotoxicity, hepatic enzyme increased, cholestasis, hepatitis

Frequency not reported: Both fatal and nonfatal hepatotoxicity have been reported in HIV-infected patients who received this drug in combination with antiretroviral agents

Respiratory

Common (1% to 10%): Pulmonary fibrosis, pulmonary edema, lung infiltration, dyspnea

Metabolic

Very rare (less than 0.01%): Tumor lysis syndrome

Psychiatric

Common (1% to 10%): Hallucination, disorientation

Renal

Very common (10% or more): Dysuria, blood creatinine increased, blood urea increased, blood uric acid increased

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Hydroxyurea (www.drugs.com/mtm/hydroxyurea.html).