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Hydroxychloroquine sulfat

Generic Name: hydroxychloroquine (hye drox ee KLOR oh kwin)
Brand Names: Plaquenil, Quineprox
Hydroxychloroquine is used to treat the symptoms of rheumatoid arthritis and systemic lupus erythematosus and to prevent and treat malaria. Includes hydroxychloroquine side effects, interactions and indications.

Average Savings for hydroxychloroquine sulfat (generic): 52.25%
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Drug Information:
Hydroxychloroquine is a quinoline medicine used to treat or prevent malaria, a disease caused by parasites that enter the body through the bite of a mosquito. Malaria is common in areas such as Africa, South America, and Southern Asia. This medicine is not effective against all strains of malaria. Hydroxychloroquine is also an antirheumatic medicine and is used to treat symptoms of rheumatoid arthritis and discoid or systemic lupus erythematosus. Taking hydroxychloroquine long-term or at high doses may cause irreversible damage to the retina of your eye. Stop taking this medicine and call your doctor at once if you have trouble focusing, if you see light streaks or flashes in your vision, or if you notice any swelling or color changes in your eyes. Learn more

Hydroxychloroquine sulfat Side Effects

Hydroxychloroquine Side Effects

For the Consumer

Applies to hydroxychloroquine: oral tablet

Along with its needed effects, hydroxychloroquine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydroxychloroquine:

Incidence not known

  • Blistering, peeling, loosening of the skin
  • blurred vision or other vision changes
  • chest discomfort, pain, or tightness
  • cough or hoarseness
  • dark urine
  • decreased urination
  • defective color vision
  • diarrhea
  • difficulty breathing
  • difficulty seeing at night
  • dizziness or fainting
  • fast, pounding, uneven heartbeat
  • feeling that others are watching you or controlling your behavior
  • feeling that others can hear your thoughts
  • feeling, seeing, or hearing things that are not there
  • fever with or without chills
  • general feeling of tiredness or weakness
  • headache
  • inability to move the eyes
  • increased blinking or spasms of the eyelid
  • joint or muscle pain
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, and sex organs
  • loss of hearing
  • lower back or side pain
  • noisy breathing
  • painful or difficult urination
  • red irritated eyes
  • red skin lesions, often with a purple center
  • severe mood or mental changes
  • sore throat sores, ulcers, or white spots on the lips or in the mouth
  • sticking out of the tongue
  • stomach pain
  • swelling of the feet or lower legs
  • swollen or painful glands
  • trouble with breathing, speaking, or swallowing
  • uncontrolled twisting movements of the neck, trunk, arms, or legs
  • unusual behavior
  • unusual bleeding or bruising
  • unusual facial expressions
  • unusual tiredness or weakness
  • yellow eyes or skin

Symptoms of overdose

  • Drowsiness
  • dry mouth
  • increased thirst
  • loss of appetite
  • mood changes
  • no pulse or blood pressure
  • numbness or tingling in the hands, feet, or lips
  • unconsciousness

Some side effects of hydroxychloroquine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Incidence not known

  • Continuing ringing or buzzing or other unexplained noise in the ears
  • feeling of constant movement of self or surroundings
  • irritability
  • nausea
  • nervousness
  • nightmares
  • sensation of spinning
  • shakiness and unsteady walk
  • uncontrolled eye movements
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • vomiting

For Healthcare Professionals

Applies to hydroxychloroquine: compounding powder, oral tablet

Cardiovascular

Frequency not reported: Cardiomyopathy (can result in fatal cardiac failure), biventricular hypertrophy

Dermatologic

-Pigmentary changes in skin and mucous membranes, bleaching of hair, and alopecia are usually reversible when therapy is discontinued.

-AGEP should be distinguished from psoriasis, although this drug may precipitate attacks of psoriasis; it may be associated with fever and hyperleukocytosis

Common (1% to 10%): Rash, pruritus

Uncommon (0.1% to 1%): Pigmentary changes in skin and mucous membranes, bleaching of hair, alopecia

Frequency not reported: Urticaria, angioedema, bullous eruptions including erythema multiforme, Stevens-Johnson syndrome and toxic epidermal necrolysis, Drug Rash with Eosinophilia and Systemic Symptoms (DRESS syndrome) photosensitivity, exfoliative dermatitis, acute generalized exanthematous pustulosis (AGEP)

Gastrointestinal

Very common (10% or more): Abdominal pain, nausea

Common (1% to 10%): Diarrhea, vomiting

Hematologic

Frequency not reported: Bone-marrow depression, anemia, aplastic anemia, agranulocytosis, leucopenia, thrombocytopenia

Hepatic

Uncommon (0.1% to 1%): Abnormal liver function tests

Frequency not reported: Fulminant hepatic failure

Hypersensitivity

Frequency not reported: Allergic reactions (urticaria, angioedema, bronchospasm), hypersensitivity myocarditis

Metabolic

Common (1% to 10%): Anorexia

Frequency not reported: Hypoglycemia, exacerbation or precipitation of porphyria

Musculoskeletal

Uncommon (0.1% to 1%): Sensorimotor disorders

Frequency not reported: Skeletal muscle myopathy or neuromyopathy (leading to progressive weakness and atrophy of proximal muscle groups), depression of tendon reflexes and abnormal nerve conduction studies

Myopathy may be reversible after therapy discontinuation, but recovery may take many months.

Nervous system

Very common (10% or more): Headache

Uncommon (0.1% to 1%): Dizziness

Frequency not reported: Seizure, vertigo, nerve deafness, ataxia

Ocular

Common (1% to 10%): Blurred vision

Uncommon (0.1% to 1%): Retinopathy (with changes in pigmentation and visual field defects), corneal changes haloes (e.g., blurring of vision, photophobia)

Frequency not reported: Maculopathies and macular degeneration (may be irreversible), extra-ocular muscle palsies (reversible), nystagmus

-Blurring of vision is due to a disturbance of accommodation which is dose dependent and reversible.

-Retinopathy is uncommon if the recommended daily dose is not exceeded. It is usually reversible if therapy is discontinued. If allowed to develop, there may be a risk of progression even after treatment withdrawal.

-Patients with retinal changes may be asymptomatic initially, or may have scotomatous vision with paracentral, pericentral ring types, temporal scotomas, and abnormal color vision.

-Corneal changes including edema and opacities can be symptomless or may cause disturbances such as haloes, blurring of vision or photophobia. They may be transient and are reversible when therapy is discontinued.

-Maculopathies and macular degeneration can occur from 3 months to several years of exposure to this drug and may be irreversible.

Other

Uncommon (0.1% to 1%): Tinnitus

Frequency not reported: Hearing loss

Psychiatric

Common (1% to 10%): Affect liability

Uncommon (0.1% to 1%): Nervousness

Frequency not reported: Psychosis, suicidal behavior

Respiratory

Frequency not reported: Bronchospasm

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Hydroxychloroquine Sulfat (www.drugs.com/hydroxychloroquine.html).