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Hydroxocobalamin

Generic Name: hydroxocobalamin (injection) (hye DROX o koe BAL a min)
Brand Name: Cyanokit, Hydroxy-Cobal, Hydro-Cobex, Cobalin-H, Neo-Cytamen
Physician reviewed Hydroxocobalamin (injection) (injection) patient information - includes Hydroxocobalamin (injection) description, dosage and directions.
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Drug Information:
Hydroxocobalamin is a form of vitamin B-12. It is used as an antidote to cyanide poisoning. Hydroxocobalamin works by helping cells in the body convert cyanide to a form that can be removed from the body through urination. Hydroxocobalamin is used in an emergency to treat cyanide poisoning. This type of poisoning can occur if you are exposed to smoke from a house or industrial fire, if you swallow or breathe in cyanide, or if you get cyanide on your skin. Hydroxocobalamin may also be used for purposes not listed in this medication guide. Learn more

Hydroxocobalamin Side Effects

Hydroxocobalamin Side Effects

For the Consumer

Applies to hydroxocobalamin: intravenous powder for solution

Along with its needed effects, hydroxocobalamin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking hydroxocobalamin:

More common

  • Blurred vision
  • dizziness
  • headache
  • nervousness
  • pounding in the ears
  • redness of the skin
  • slow or fast heartbeat

Incidence not known

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • cough
  • difficult or labored breathing
  • difficulty with swallowing
  • feeling of warmth
  • hives or welts, itching, or skin rash
  • large, hive-like swelling on the , eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • rapid weight gain
  • redness of the face, neck, arms, and occasionally, upper chest
  • sudden sweating
  • tightness in the chest
  • tingling of the hands or feet
  • unusual tiredness or weakness
  • unusual weight gain or loss

Some side effects of hydroxocobalamin may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Blemishes on the skin
  • dry, red, hot, or irritated skin
  • nausea
  • pimples
  • red colored urine

Incidence not known

  • Acid or sour stomach
  • being forgetful
  • belching
  • diarrhea
  • heartburn
  • indigestion
  • redness or swelling of the eyes
  • restlessness
  • stomach discomfort, upset, or pain

For Healthcare Professionals

Applies to hydroxocobalamin: compounding powder, injectable solution, intravenous powder for injection

Cardiovascular

Ventricular extrasystoles, electrocardiogram repolarization abnormality, and heart rate increased were seen in known/suspected cyanide poisoning patients.

Very common (10% or more): Blood pressure increased (28% with 10 gram dose)

Frequency not reported: Increased blood pressure (particularly diastolic), hot flush, ventricular extrasystoles, electrocardiogram repolarization abnormality, heart rate increased

Gastrointestinal

Very common (10% or more): Nausea (11% with 10 gram dose)

Frequency not reported: Dysphagia, abdominal discomfort, vomiting, diarrhea, dyspepsia, hematochezia

Dermatologic

Very common (10% or more): Erythema (100% with 10 gram dose), rash (primarily acneiform) (44% with 10 gram dose)

Frequency not reported: Urticaria, pruritus

Genitourinary

Very common (10% or more): Chromaturia (red colored urine) (100% with 5 or 10 gram dose), oxalate crystals in urine (61% with 5 gram dose)

Postmarketing reports: Urine calcium oxalate crystals

Hematologic

Very common (10% or more): Lymphocyte count decreased (17% with 10 gram dose)

Local

Very common (10% or more): Infusion site reaction (39% with 10 gram dose)

Renal

Postmarketing reports: Acute renal failure with acute tubular necrosis, renal impairment

Nervous system

Very common (10% or more): Headache (33% with 10 gram dose)

Frequency not reported: Memory impairment, dizziness

Respiratory

Pleural effusion was seen in known/suspected cyanide poisoning patients.

Frequency not reported: Dyspnea, throat tightness, dry throat, pleural effusion

Hypersensitivity

Frequency not reported: Allergic reaction

Ocular

Frequency not reported: Swelling, irritation, redness

Other

Frequency not reported: Peripheral edema, chest discomfort

Psychiatric

Frequency not reported: Restlessness

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Hydroxocobalamin (www.drugs.com/mtm/hydroxocobalamin-injection.html).