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Hydralazine Hydrochloride

Hydralazine hydrochloride Prescription
Generic Name: hydralazine (hye DRAL a zeen)
Brand Name: Apresoline
Physician reviewed hydralazine patient information - includes hydralazine description, dosage and directions.

Average Savings for hydralazine hydrochloride (generic): 37.96%
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Hydralazine Hydrochloride Drug Information:

Hydralazine is a vasodilator that works by relaxing the muscles in your blood vessels to help them dilate (widen). This lowers blood pressure and allows blood to flow more easily through your veins and arteries. Hydralazine is used to treat high blood pressure (hypertension). Hydralazine may also be used for purposes not listed in this medication guide. You should not use hydralazine if you have coronary artery disease, or rheumatic heart disease affecting the mitral valve. You should not use hydralazine if you are allergic to it, or if you have: Learn more

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Hydralazine Hydrochloride Side Effects

For the Consumer

Applies to hydralazine: oral tablet

Other dosage forms:

  • injection solution
Side effects requiring immediate medical attention

Along with its needed effects, hydralazine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking hydralazine:

More common

  • Arm, back, or jaw pain
  • chest pain or discomfort
  • chest tightness or heaviness
  • fast, pounding, or irregular heartbeat or pulse
  • nausea
  • shortness of breath
  • sweating

Less common

  • Black, tarry stools
  • blindness or vision changes
  • blisters on the skin
  • blurred vision
  • burning of the face or mouth
  • burning, crawling, itching, numbness, painful, prickling, "pins and needles", or tingling feelings
  • chills
  • clumsiness or unsteadiness
  • confusion
  • cough
  • difficult or labored breathing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fever and sore throat
  • general feeling of discomfort or illness or weakness
  • joint pain
  • lower back or side pain
  • muscle pain
  • numbness, tingling, pain, or weakness in the hands or feet
  • painful or difficult urination
  • pale skin
  • shakiness in the legs, arms, hands, or feet
  • skin rash or itching
  • swelling of the feet or lower legs
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • tightness in the chest
  • trembling or shaking of the hands or feet
  • ulcers, sores, or white spots in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • weakness in hands or feet


  • Dark urine
  • light-colored stools
  • upper right abdominal or stomach pain
  • yellow eyes and skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking hydralazine:

Symptoms of overdose

  • Feeling of warmth
  • headache
  • redness of the face, neck, arms, and occasionally, upper chest
Side effects not requiring immediate medical attention

Some side effects of hydralazine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Diarrhea
  • loss of appetite
  • weight loss

Less common

  • Constipation
  • difficulty with moving
  • dizziness
  • feeling anxious or depressed
  • muscle cramps, pain, or stiffness
  • pain in the joints
  • rash, hives, welts, or itching
  • stuffy nose
  • watery eyes

For Healthcare Professionals

Applies to hydralazine: compounding powder, injectable solution, oral tablet


The most frequently reported side effects were palpitations and tachycardia.


Very common (10% or more): Palpitations, tachycardia

Common (1% to 10%): Angina pectoris, flushing, hypotension

Uncommon (0.1% to 1%): Heart failure, vasculitis

Very rare (less than 0.01%): Paradoxical pressor response


Common (1% to 10%): Nausea, vomiting, diarrhea, gastrointestinal disturbances

Very rare (less than 0.01%): Paralytic ileus

Frequency not reported: Constipation

Nervous system

Common (1% to 10%): Headache

Uncommon (0.1% to 1%): Dizziness

Very rare (less than 0.01%): Peripheral neuritis, paresthesia, tremor, polyneuritis

Frequency not reported: Tingling, numbness


Common (1% to 10%): Arthralgia, joint swelling, myalgia

Uncommon (0.1% to 1%): Systemic lupus erythematosus-like syndrome

Frequency not reported: Muscle cramp


Common (1% to 10%): Anorexia


Common (1% to 10%): Positive antinuclear factor


Uncommon (0.1% to 1%): Nasal congestion, dyspnea, pleural pain


Uncommon (0.1% to 1%): Anemia, leukopenia, neutropenia, thrombocytopenia

Very rare (less than 0.01%): Hemolytic anemia, leukocytosis, lymphadenopathy, pancytopenia, splenomegaly, agranulocytosis, eosinophilia

Frequency not reported: Blood dyscrasias, hemoglobin decreased, red cell count decreased


Uncommon (0.1% to 1%): Serum creatinine increased, glomerulonephritis

Very rare (less than 0.01%): Acute renal failure


Uncommon (0.1% to 1%): Rash, purpura, urticaria, pruritus


Uncommon (0.1% to 1%): Jaundice, liver enlarged, abnormal liver function, hepatitis


Uncommon (0.1% to 1%): Hypersensitivity reaction


Uncommon (0.1% to 1%): Proteinuria, hematuria, urinary retention

Very rare (less than 0.01%): Retroperitoneal fibrosis

Frequency not reported: Urination difficult


Uncommon (0.1% to 1%): Lacrimation increased, conjunctivitis

Very rare (less than 0.01%): Exophthalmos


Uncommon (0.1% to 1%): Edema, fever, weight decreased, malaise

Frequency not reported: Chills


Uncommon (0.1% to 1%): Agitation, anxiety

Very rare (less than 0.01%): Depression, hallucinations

Frequency not reported: Psychotic reactions, disorientation, anxiety

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Hydralazine Hydrochloride (www.drugs.com/mtm/hydralazine.html).