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Humalog Prescription
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Generic Name: insulin lispro (IN soo lin LISS pro)
Brand Names: Admelog, Humalog
Humalog (insulin lispro) is used to treat type 1 (insulin-dependent) diabetes in adults. Includes Humalog side effects, interactions and indications.
Generic Name: insulin lispro (IN soo lin LISS pro)
Brand Names: Admelog, Humalog
Humalog (insulin lispro) is used to treat type 1 (insulin-dependent) diabetes in adults. Includes Humalog side effects, interactions and indications.
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1 tablets of Humalog 40 mg
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Humalog Drug Information:

Humalog (Insulin Lispro) is a fast-acting insulin that starts to work about 15 minutes after injection, peaks in about 1 hour, and keeps working for 2 to 4 hours. Insulin is a hormone that works by lowering levels of glucose (sugar) in the blood. Humalog is used to improve blood sugar control in adults and children with Diabetes mellitus. Humalog is used to treat type 2 Diabetes in adults. Humalog is also used to treat type 1 Diabetes in adults and children who are at least 3 years old. Humalog is a fast-acting insulin that begins to work very quickly. If you use this medication with meal, use it within 15 minutes before or just after you eat. Learn more

Humalog Medicare Coverage

Humalog Medicare Overview

Does Medicare cover Humalog?


In general, Medicare plans do not cover this drug. This drug will likely be quite expensive and you may want to consider using a USARx discount instead of Medicare to find the best price for this prescription.
How much is my Humalog co-pay with Medicare?

It depends. Which coverage stage are you in? Click on a tab below…



In the Deductible co-pay stage, you are responsible for the full cost of your prescriptions. Your Medicare deductible cannot exceed $360 in 2016.

Ways to Save on Humalog

Here are some ways that may lower the cost of your humalog prescription.

  • Instead of Medicare, Use a USA Rx Coupon

    If your Medicare co-pay is higher, you can save money by using a USARx coupon instead.

Humalog Side Effects

Note: This document contains side effect information about insulin lispro. Some of the dosage forms listed on this page may not apply to the brand name Humalog.

For the Consumer

Applies to insulin lispro: suspension

Along with its needed effects, insulin lispro (the active ingredient contained in Humalog) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking insulin lispro:

More common

  • Anxious or nervous feeling
  • behavior change similar to being drunk
  • blurred vision
  • chills
  • cold sweats
  • confusion or difficulty thinking
  • depression
  • dizziness or lightheadedness
  • drowsiness
  • excessive hunger
  • fast heartbeat
  • fever
  • headache
  • irritability or abnormal behavior
  • lower back or side pain
  • nightmares
  • painful or difficult urination
  • restless sleep
  • seizures
  • shakiness
  • slurred speech
  • tingling in the hands, feet, lips, or tongue

Less common

  • Dry, red, hot, or irritated skin


  • Depression of the skin at the injection site
  • dryness of the mouth
  • fast or weak pulse
  • itching, redness, or swelling at the injection site
  • muscle cramps or pain
  • nausea
  • skin rash or itching over the whole body
  • sweating
  • thickening of the skin at the injection site
  • trouble breathing
  • unusual tiredness or weakness
  • vomiting

Incidence not known

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • decreased urine
  • difficulty with swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, pounding, or irregular heartbeat or pulse
  • hives or itching skin
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • redistribution or accumulation of body fat
  • tightness in the chest
  • unusual weight gain or loss

Some side effects of insulin lispro may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Body aches or pain
  • congestion
  • runny nose
  • sneezing
  • sore throat
  • stuffy nose
  • tender, swollen glands in the neck
  • unusual tiredness or weakness
  • voice changes

Incidence not known

  • Redness, swelling, or itching at the injection site

For Healthcare Professionals

Applies to insulin lispro: injectable solution, subcutaneous solution


Adverse reactions observed have included hypoglycemia, allergic reactions, local injection site reactions, lipodystrophy, rash, and pruritus.


Weight gain has been reported with insulin therapy and has been attributed to the anabolic effects of insulin and the decrease in glucosuria.

Very common (10% or more): Hypoglycemia

Frequency not reported: Weight gain


Frequency not reported: Allergic reactions including anaphylaxis

Hypersensitivity side effects have included both local and systemic reactions. Anaphylaxis has been reported. Local reactions have presented as erythema, local edema, and pruritus at the injection site. Most minor reactions to insulin at the injection site resolve in a few days to a few weeks.

Generalized allergy to insulin may present as a whole body rash, dyspnea, wheezing, hypotension, tachycardia, or diaphoresis. In clinical trials, pruritus (with or without rash) was seen in 17 patients receiving human insulin (n=2969) and 30 patients receiving insulin lispro (n=2944).


Common (1% to 10%): Infusion site reactions

Rare (less than 0.1%): Catheter occlusions/month


Rapid improvement in glucose control has been associated with a transitory, reversible ophthalmologic refraction disorder and worsening of diabetic retinopathy. However, long-term glycemic control decreases the risk of diabetic retinopathy.

Uncommon (0.1% to 1%): Refraction disorder, worsening of diabetic retinopathy

Nervous system

Very common (10% or more): Headache (up to 29.6%)

Rare (less than 0.1%): Painful peripheral neuropathy

Rapid improvement in glucose control has been associated with a transitory, reversible acute painful peripheral neuropathy. However, long-term glycemic control decreases the risk.


The clinical significance of the development of these antibody titers is unknown.

Very common (10% or more): Flu syndrome (up to 34.6%), infection (up to 13.6%)

Frequency not reported: Anti-insulin antibody titers


Frequency not reported: Peripheral edema

Insulin may cause sodium retention and edema, especially as metabolic control is improving.


Long-term use of insulin may cause lipodystrophy at the site of repeated injection. Lipodystrophy includes lipohypertrophy, a thickening of adipose tissue, and lipoatrophy, thinning of adipose tissue.

Uncommon (0.1% to 1%): Urticaria, rash

Frequency not reported: Lipodystrophy including lipohypertrophy and lipoatrophy


Common (1% to 10%): Nausea, diarrhea, abdominal pain


Common (1% to 10%): Urinary tract infection, dysmenorrhea


Common (1% to 10%): Myalgia


Very common (10% or more): Pain (up to 19.8%)

Common (1% to 10%): Fever


Very common (10% or more): Pharyngitis (up to 33.3%), rhinitis (up to 24.7%), increased cough (up to 17.3%)

Common (1% to 10%): Sinusitis, bronchitis

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.

Source: Drugs.com Humalog (www.drugs.com/humalog.html).