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Horizant Prescription
Generic Name: gabapentin enacarbil
Brand Names: Horizant
Horizant (gabapentin enacarbil) is used to treat restless legs syndrome and nerve pain caused by the herpes virus. Includes Horizant side effects, interactions and indications.
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Horizant Drug Information:

Horizant (Gabapentin enacarbil) is a prescription medicine used to treat adults with restless legs syndrome and pain from damaged nerves. It affects chemicals and nerves in the body that are involved in the cause of some types of pain. Horizant is used in adults to treat nerve pain (postherpetic neuralgia) caused by herpes virus or shingles (herpes zoster). Horizant is also used to treat restless legs syndrome (RLS). Use only the brand and form of Gabapentin your doctor has prescribed. Check your medicine each time you get a refill to make sure you receive the correct form. Learn more

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Horizant Side Effects

Note: This document contains side effect information about gabapentin enacarbil. Some of the dosage forms listed on this page may not apply to the brand name Horizant.

In Summary

Common side effects of Horizant include: dizziness, drowsiness, and sedated state. Other side effects include: irritability. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to gabapentin enacarbil: oral tablet extended release

Along with its needed effects, gabapentin enacarbil (the active ingredient contained in Horizant) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking gabapentin enacarbil:

More common

  • Bloating or swelling of the face, arms, hands, lower legs, or feet
  • discouragement
  • feeling sad or empty
  • irritability
  • lack of appetite
  • loss of interest or pleasure
  • rapid weight gain
  • tingling of the hands or feet
  • tiredness
  • trouble concentrating

Incidence not known

  • Black, tarry stools
  • bloody or cloudy urine
  • changes in behavior
  • chest pain or discomfort
  • chills or fever
  • confusion
  • difficulty with breathing
  • dizziness or lightheadedness
  • fainting
  • fast heartbeat
  • nausea or vomiting
  • painful or difficult urination
  • rapid, shallow breathing
  • rash
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • swelling of the face, feet, or lower legs
  • swollen, painful, or tender lymph glands in the neck, armpit, or groin
  • thoughts of killing oneself
  • unusual bleeding or bruising
  • upper right abdominal or stomach pain
  • yellow eyes and skin

Some side effects of gabapentin enacarbil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Lack or loss of strength
  • sleepiness or unusual drowsiness

Less common

  • Blurred vision
  • decreased interest in sexual intercourse
  • dry mouth
  • excess air or gas in the stomach or intestines
  • inability to have or keep an erection
  • sensation of spinning
  • weight gain

For Healthcare Professionals

Applies to gabapentin enacarbil: compounding powder, oral capsule, oral solution, oral tablet, oral tablet extended release

Cardiovascular

Common (1% to 10%): Peripheral edema, vasodilation, hypertension

Rare (less than 0.1%): Atrial fibrillation, heart failure, myocardial infarction, cerebrovascular accident, ventricular extrasystoles, bradycardia, premature atrial contraction, pericardial rub, heart block, pericardial effusion, pericarditis

Postmarketing reports: Cardiac arrest, chest pain, palpitation, tachycardia

Dermatologic

Common (1% to 10%): Abrasion, facial edema, purpura, rash, pruritus, acne

Uncommon (0.1% to 1%): Alopecia, eczema, dry skin, increased sweating, urticaria, hirsutism, seborrhea, cyst, herpes simplex

Rare (less than 0.1%): Stevens-Johnson syndrome, angioedema, erythema multiforme, drug rash (with eosinophilia and systemic symptoms), herpes zoster, skin discolor, skin papules, photosensitive reaction, psoriasis, desquamation, maceration, skin nodules, subcutaneous nodule, melanosis, skin necrosis, local swelling

Frequency not reported: DRESS/multiorgan hypersensitivity

Endocrine

Rare (less than 0.1%): Hyperthyroid, hypothyroid, goiter, hypoestrogenism, ovarian failure, epididymitis, cushingoid appearance

Gastrointestinal

Common (1% to 10%): Diarrhea, dry mouth or throat, constipation, nausea, vomiting, dyspepsia, dental abnormalities, gingivitis, abdominal pain, flatulence

Uncommon (0.1% to 1%): Glossitis, gum hemorrhage, thirst, stomatitis, increased salivation, gastroenteritis, hemorrhoids, bloody stools, fecal incontinence

Rare (less than 0.1%): Pancreatitis, dysphagia, eructation, pancreatitis, peptic ulcer, colitis, blisters in mouth, tooth discoloration, perlèche, salivary gland enlarged, lip hemorrhage, esophagitis, hiatal hernia, hematemesis, proctitis, irritable bowel syndrome, rectal hemorrhage, esophageal spasm

Frequency not reported: Dehydration

General

The most common adverse reactions associated with the use of this drug were dizziness, somnolence, and peripheral edema.

Genitourinary

Common (1% to 10%): Incontinence, impotence

Uncommon (0.1% to 1%): Hematuria, dysuria, urinary frequency, cystitis, urinary retention, vaginal hemorrhage, amenorrhea, dysmenorrhea, menorrhagia

Frequency not reported: Breast hypertrophy, gynecomastia, sexual dysfunction (including changes in libido, ejaculation disorders, and anorgasmia)

Hematologic

Common (1% to 10%): Leucopenia, purpura

Uncommon (0.1% to 1%): Anemia, lymphadenopathy

Rare (less than 0.1%): Thrombocytopenia, thrombophlebitis, leukocytosis, lymphocytosis, increased bleeding time

Frequency not reported: Blood creatine phosphokinase increased, coagulation defect

Hepatic

Rare (less than 0.1%): Hepatitis, jaundice, elevated liver function tests SGOT (AST), SGPT (ALT), and bilirubin, hepatomegaly, hepatotoxicity

Hypersensitivity

Very rare (less than 0.01%): Hypersensitivity syndrome, a systemic reaction with a variable presentation that can include fever, rash, hepatitis, lymphadenopathy, eosinophilia, and sometimes other signs and symptoms

Metabolic

Common (1% to 10%): Weight gain, hyperglycemia

Postmarketing reports: Hyponatremia

Musculoskeletal

Common (1% to 10%): Back pain, arthralgia, myalgia, twitching

Uncommon (0.1% to 1%): Tendonitis, arthritis, joint stiffness, joint swelling

Frequency not reported: Rhabdomyolysis, myoclonus

Postmarketing reports: Elevated creatine kinase, rhabdomyolysis

Nervous system

Very common (10% or more): Somnolence (21%), dizziness (17%), ataxia (13%)

Common (1% to 10%): Abnormal gait, incoordination, neuralgia, tremor, dysarthria, hyperkinesia, seizures, dysarthria, paresthesia, hypesthesia, coordination abnormal, increased/decreased/absent reflexes, vertigo

Uncommon (less than 1%): Hypokinesia

Rare (less than 0.1%): Movement disorders (e.g., choreoathetosis, dyskinesia, dystonia), loss of consciousness

Frequency not reported: Withdrawal precipitated seizure/status epilepticus

Postmarketing reports: Movement disorder

Ocular

Common (1% to 10%): Amblyopia, conjunctivitis, diplopia, nystagmus

Uncommon (0.1% to 1%): Cataract, dry eyes, eye pain, visual field defect, photophobia, bilateral or unilateral ptosis, eye hemorrhage, hordeolum, eye twitching

Rare (less than 0.1%): Eye itching, abnormal accommodation, eye focusing problem, watery eyes, retinopathy, glaucoma, iritis, corneal disorders, lacrimal dysfunction, degenerative eye changes, blindness, retinal degeneration, miosis, chorioretinitis, strabismus

Oncologic

Uncommon (0.1% to 1%): Breast cancer

Rare (less than 0.1%): Non-Hodgkin's lymphoma

Other

Very common (10% or more): Fatigue (11%), fever (11%)

Common (1% to 10%): Asthenia, accidental injury, otitis media, tremor, pain

Rare (0.01% to 0.1%): Tinnitus

Very rare (less than 0.01%): Sudden unexplained death in patients with epilepsy

Frequency not reported: Sleepwalking, withdrawal symptoms, hearing loss, earache, tinnitus, inner ear infection, otitis, taste loss, unusual taste, ear fullness, perforated ear drum, sensitivity to noise, eustachian tube dysfunction, otitis externa, odd smell, labyrinthitis

Psychiatric

Common (1% to 10%): Abnormal thinking, amnesia, depression, hostility, confusion, emotional liability, anxiety, nervousness, insomnia

Uncommon (0.1% to 1%): Mental impairment

Rare (less than 0.1%): Hallucinations

Frequency not reported: Suicidal behavior and ideation, hypomania

Renal

Rare (less than 0.1%): Acute renal failure

Respiratory

Common (1% to 10%): Pharyngitis, dyspnea, cough, bronchitis, respiratory infection, rhinitis

Rare (less than 0.1%): Pulmonary thrombosis, pulmonary embolism

Frequency not reported: Pseudo-croup, hoarseness

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Horizant (www.drugs.com/horizant.html).

What pharmacies accept this patient assistance program?

Rite Aid, Wal-Mart, Walgreens, CVS, Duane Reade, Target, K-mart, and all national and regional chains accept the savings card.

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What if the pharmacist refuses to take the card?

If they are in the participating network, they legally have to accept and process the card. If they need help in processing the card, have them call the support phone number or email us directly. Our e-mail address can be found on our web site, as well as our terms of use.

What if the dosage, quantity, or drug name of the Horizant coupon I downloaded is different from what I’m trying to fill right now?

Any Horizant coupon can be applied to any prescription drug at a participating pharmacy and receive a discount. Prescription prices are subject to change and we do not provide a warranty on those listed here.

Who is defined as eligible patients for the free Horizant coupon?

Anyone in the United States and U.S. territories such as Puerto Rico are deemed eligible patients.

Does this Horizant coupon card work for brand name drug and the generic version?

Yes, both generic and brand prescription medication are covered by the coupon. Remember, any coupon can be applied to any prescription drug at a participating pharmacy with this patient assistance program.

Horizant Prescription Savings Explained

FAQ Disclaimer: USA Rx LLC has a full endorsement of our prescription savings discount program. This product does not replace your insurance plan. You may check the price of both your insurance plan (copay) and our patient assistance program. We work with our affiliates to find the best way to get the lowest out of pocket cost on your prescriptions. Our affiliates use the “powered by USA Rx” symbol in marketing materials. If you have a medical condition and need savings tips or assistance with figuring out your best option is for a discount program of prescription savings and lower prices, or you have questions about our terms of use, please give us a call or drop us an e-mail. Our e-mail address is listed on our web site, as well as our terms of use for informational purposes. Visit our web site for new discount codes. A Horizant prescription is intended to treat severe restless legs syndrome and works for management of postherpetic neuralgia (PHN). The Horizant oral tablet should be taken on a regular schedule according to your doctor's instructions. Horizant is not the same as Neurontin, although Neurontin may be used for similar treatments.  If you need medical help with PHN or any other serious condition, please seek proper medical care as soon as possible. All cardholders adhere to our privacy policy and we use recent information to create our pricing estimates, which are subject to change, as per our terms of use. USA Rx provides no warranty for the pricing information on this web site. See our terms of use for more information. Prescription prices are subject to change.