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Note: This document contains side effect information about gabapentin enacarbil. Some of the dosage forms listed on this page may not apply to the brand name Horizant.
In SummaryCommon side effects of Horizant include: dizziness, drowsiness, and sedated state. Other side effects include: irritability. See below for a comprehensive list of adverse effects.
For the ConsumerApplies to gabapentin enacarbil: oral tablet extended release
Along with its needed effects, gabapentin enacarbil (the active ingredient contained in Horizant) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking gabapentin enacarbil:
More common
Incidence not known
Some side effects of gabapentin enacarbil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
For Healthcare Professionals
Applies to gabapentin enacarbil: compounding powder, oral capsule, oral solution, oral tablet, oral tablet extended release
CardiovascularCommon (1% to 10%): Peripheral edema, vasodilation, hypertension
Rare (less than 0.1%): Atrial fibrillation, heart failure, myocardial infarction, cerebrovascular accident, ventricular extrasystoles, bradycardia, premature atrial contraction, pericardial rub, heart block, pericardial effusion, pericarditis
Postmarketing reports: Cardiac arrest, chest pain, palpitation, tachycardia
DermatologicCommon (1% to 10%): Abrasion, facial edema, purpura, rash, pruritus, acne
Uncommon (0.1% to 1%): Alopecia, eczema, dry skin, increased sweating, urticaria, hirsutism, seborrhea, cyst, herpes simplex
Rare (less than 0.1%): Stevens-Johnson syndrome, angioedema, erythema multiforme, drug rash (with eosinophilia and systemic symptoms), herpes zoster, skin discolor, skin papules, photosensitive reaction, psoriasis, desquamation, maceration, skin nodules, subcutaneous nodule, melanosis, skin necrosis, local swelling
Frequency not reported: DRESS/multiorgan hypersensitivity
EndocrineRare (less than 0.1%): Hyperthyroid, hypothyroid, goiter, hypoestrogenism, ovarian failure, epididymitis, cushingoid appearance
GastrointestinalCommon (1% to 10%): Diarrhea, dry mouth or throat, constipation, nausea, vomiting, dyspepsia, dental abnormalities, gingivitis, abdominal pain, flatulence
Uncommon (0.1% to 1%): Glossitis, gum hemorrhage, thirst, stomatitis, increased salivation, gastroenteritis, hemorrhoids, bloody stools, fecal incontinence
Rare (less than 0.1%): Pancreatitis, dysphagia, eructation, pancreatitis, peptic ulcer, colitis, blisters in mouth, tooth discoloration, perlèche, salivary gland enlarged, lip hemorrhage, esophagitis, hiatal hernia, hematemesis, proctitis, irritable bowel syndrome, rectal hemorrhage, esophageal spasm
Frequency not reported: Dehydration
GeneralThe most common adverse reactions associated with the use of this drug were dizziness, somnolence, and peripheral edema.
GenitourinaryCommon (1% to 10%): Incontinence, impotence
Uncommon (0.1% to 1%): Hematuria, dysuria, urinary frequency, cystitis, urinary retention, vaginal hemorrhage, amenorrhea, dysmenorrhea, menorrhagia
Frequency not reported: Breast hypertrophy, gynecomastia, sexual dysfunction (including changes in libido, ejaculation disorders, and anorgasmia)
HematologicCommon (1% to 10%): Leucopenia, purpura
Uncommon (0.1% to 1%): Anemia, lymphadenopathy
Rare (less than 0.1%): Thrombocytopenia, thrombophlebitis, leukocytosis, lymphocytosis, increased bleeding time
Frequency not reported: Blood creatine phosphokinase increased, coagulation defect
HepaticRare (less than 0.1%): Hepatitis, jaundice, elevated liver function tests SGOT (AST), SGPT (ALT), and bilirubin, hepatomegaly, hepatotoxicity
HypersensitivityVery rare (less than 0.01%): Hypersensitivity syndrome, a systemic reaction with a variable presentation that can include fever, rash, hepatitis, lymphadenopathy, eosinophilia, and sometimes other signs and symptoms
MetabolicCommon (1% to 10%): Weight gain, hyperglycemia
Postmarketing reports: Hyponatremia
MusculoskeletalCommon (1% to 10%): Back pain, arthralgia, myalgia, twitching
Uncommon (0.1% to 1%): Tendonitis, arthritis, joint stiffness, joint swelling
Frequency not reported: Rhabdomyolysis, myoclonus
Postmarketing reports: Elevated creatine kinase, rhabdomyolysis
Nervous systemVery common (10% or more): Somnolence (21%), dizziness (17%), ataxia (13%)
Common (1% to 10%): Abnormal gait, incoordination, neuralgia, tremor, dysarthria, hyperkinesia, seizures, dysarthria, paresthesia, hypesthesia, coordination abnormal, increased/decreased/absent reflexes, vertigo
Uncommon (less than 1%): Hypokinesia
Rare (less than 0.1%): Movement disorders (e.g., choreoathetosis, dyskinesia, dystonia), loss of consciousness
Frequency not reported: Withdrawal precipitated seizure/status epilepticus
Postmarketing reports: Movement disorder
OcularCommon (1% to 10%): Amblyopia, conjunctivitis, diplopia, nystagmus
Uncommon (0.1% to 1%): Cataract, dry eyes, eye pain, visual field defect, photophobia, bilateral or unilateral ptosis, eye hemorrhage, hordeolum, eye twitching
Rare (less than 0.1%): Eye itching, abnormal accommodation, eye focusing problem, watery eyes, retinopathy, glaucoma, iritis, corneal disorders, lacrimal dysfunction, degenerative eye changes, blindness, retinal degeneration, miosis, chorioretinitis, strabismus
OncologicUncommon (0.1% to 1%): Breast cancer
Rare (less than 0.1%): Non-Hodgkin's lymphoma
OtherVery common (10% or more): Fatigue (11%), fever (11%)
Common (1% to 10%): Asthenia, accidental injury, otitis media, tremor, pain
Rare (0.01% to 0.1%): Tinnitus
Very rare (less than 0.01%): Sudden unexplained death in patients with epilepsy
Frequency not reported: Sleepwalking, withdrawal symptoms, hearing loss, earache, tinnitus, inner ear infection, otitis, taste loss, unusual taste, ear fullness, perforated ear drum, sensitivity to noise, eustachian tube dysfunction, otitis externa, odd smell, labyrinthitis
PsychiatricCommon (1% to 10%): Abnormal thinking, amnesia, depression, hostility, confusion, emotional liability, anxiety, nervousness, insomnia
Uncommon (0.1% to 1%): Mental impairment
Rare (less than 0.1%): Hallucinations
Frequency not reported: Suicidal behavior and ideation, hypomania
RenalRare (less than 0.1%): Acute renal failure
RespiratoryCommon (1% to 10%): Pharyngitis, dyspnea, cough, bronchitis, respiratory infection, rhinitis
Rare (less than 0.1%): Pulmonary thrombosis, pulmonary embolism
Frequency not reported: Pseudo-croup, hoarseness
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Horizant (www.drugs.com/horizant.html).
February 5, 2021
July 31, 2020
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FAQ Disclaimer: USA Rx LLC has a full endorsement of our prescription savings discount program. This product does not replace your insurance plan. You may check the price of both your insurance plan (copay) and our patient assistance program. We work with our affiliates to find the best way to get the lowest out of pocket cost on your prescriptions. Our affiliates use the “powered by USA Rx” symbol in marketing materials. If you have a medical condition and need savings tips or assistance with figuring out your best option is for a discount program of prescription savings and lower prices, or you have questions about our terms of use, please give us a call or drop us an e-mail. Our e-mail address is listed on our web site, as well as our terms of use for informational purposes. Visit our web site for new discount codes. A Horizant prescription is intended to treat severe restless legs syndrome and works for management of postherpetic neuralgia (PHN). The Horizant oral tablet should be taken on a regular schedule according to your doctor's instructions. Horizant is not the same as Neurontin, although Neurontin may be used for similar treatments. If you need medical help with PHN or any other serious condition, please seek proper medical care as soon as possible. All cardholders adhere to our privacy policy and we use recent information to create our pricing estimates, which are subject to change, as per our terms of use. USA Rx provides no warranty for the pricing information on this web site. See our terms of use for more information. Prescription prices are subject to change.