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Heparin sodium lock flush

Generic Name: heparin (injection) (HEP a rin)
Brand Names: Hep-Pak (obsolete), Heparin Lock Flush (obsolete), Hep-Pak CVC (obsolete), Hep-Lock (obsolete), Heparin Sodium ADD-Vantage
Heparin injection is used to treat and prevent blood clots in the veins, arteries, or lungs. Learn about side effects, interactions and indications.
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Drug Information:
Heparin is an anticoagulant (blood thinner) that prevents the formation of blood clots. Heparin is used to treat and prevent blood clots caused by certain medical conditions or medical procedures. It is also used before surgery to reduce the risk of blood clots. Do not use heparin injection to flush (clean out) an intravenous (IV) catheter. A separate product is available to use as catheter lock flush. Using the wrong type of heparin to flush a catheter can result in fatal bleeding. Do not use heparin injection to flush (clean out) an intravenous (IV) catheter, or fatal bleeding could result. A separate product is available to use as catheter lock flush. Learn more

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Heparin sodium lock flush Side Effects

For the Consumer

Applies to heparin: solution

Along with its needed effects, heparin may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking heparin:

Less common

  • Abdominal or stomach pain or swelling
  • back pain or backaches
  • bleeding from the gums when brushing teeth
  • blood in the urine
  • constipation
  • coughing up blood
  • dizziness
  • headaches, severe or continuing
  • heavy bleeding or oozing from cuts or wounds
  • joint pain, stiffness, or swelling
  • menstrual bleeding, unexpected or unusually heavy
  • unexplained bruising or purplish areas on the skin
  • unexplained nosebleeds
  • vomiting of blood or material that looks like coffee grounds

Rare

  • Blood under the skin (blood blister) at the place of injection
  • chest pain
  • chills or fever
  • fast or irregular breathing
  • irritation, pain, redness, or ulcers at the place of injection
  • itching and burning feeling, especially on the bottom of the feet
  • nausea or vomiting
  • numbness or tingling in the hands or feet
  • pain, coldness, or blue color of the skin on the arms or legs
  • peeling of the skin
  • puffiness or swelling of the eyelids or around the eyes
  • shortness of breath
  • skin color change, especially near the place of injection or in the fingers, toes, arms, or legs
  • skin rash, hives, or itching
  • tearing of the eyes
  • tightness in the chest
  • trouble with breathing
  • wheezing

After you stop using this medicine, it may still produce some side effects that need attention. During this period of time, check with your doctor immediately if you notice the following side effects:

  • Black, tarry stools
  • bleeding gums
  • blood in the urine or stools
  • pain in the chest, groin, or legs, especially calves of legs
  • pinpoint red spots on the skin
  • severe headaches of sudden onset
  • sudden loss of coordination
  • sudden shortness of breath for no apparent reason
  • sudden slurred speech
  • sudden vision changes
  • unusual bleeding or bruising

For Healthcare Professionals

Applies to heparin: injectable kit, injectable solution, intravenous solution

General

The most common adverse reaction was hemorrhage.

Cardiovascular

Postmarketing reports: Hemorrhage, retroperitoneal hemorrhage

Hematologic

Very common (10% or more): Thrombocytopenia (up to 30%)

Frequency not reported: Plasma lipoprotein lipase increased

Postmarketing reports: Heparin resistance

Hypersensitivity

Frequency not reported: Conjunctivitis, cyanosis, tachypnea, feeling of oppression, angioneurotic edema, anaphylactic shock

Postmarketing reports: Chills, fever, urticaria, asthma, rhinitis, lacrimation, headache, nausea, vomiting, anaphylactoid reactions, shock, itching, burning

Local

Frequency not reported: Erythematous nodules, infiltrated and sometimes eczema-like plaques

Postmarketing reports: Local irritation, erythema, mild pain, hematoma, ulceration, histamine-like reactions, skin necrosis

Immunologic

Frequency not reported: Allergic reactions, hypereosinophilia

Postmarketing reports: Heparin-induced thrombocytopenia, heparin-induced thrombocytopenia and thrombosis, generalized hypersensitivity reactions

Endocrine

Frequency not reported: Hypoaldosteronism

Postmarketing reports: Adrenal hemorrhage, acute adrenal insufficiency, fatal adrenal hemorrhage, aldosterone synthesis suppressed

Metabolic

Frequency not reported: Plasma potassium increased, hyperkalemia, metabolic acidosis

Postmarketing reports: Rebound hyperlipidemia

Musculoskeletal

Frequency not reported: Significant bone demineralization, spontaneous bone fracture

Postmarketing reports: Osteoporosis

Dermatologic

Frequency not reported: Ecchymoses

Postmarketing reports: Cutaneous necrosis, delayed transient alopecia

Hepatic

Frequency not reported: Serum transaminases increased

Postmarketing reports: ALT elevated significantly, AST elevated significantly

Genitourinary

Postmarketing reports: Ovarian hemorrhage, priapism

Renal

Frequency not reported: Renal function suppression

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Heparin Sodium Lock Flush (www.drugs.com/heparin.html).