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Glyburide Prescription
Generic Name: glyburide (GLYE bue ride)
Brand Names: DiaBeta, glynase prestab, Micronase
Glyburide is used to treat type 2 diabetes along with diet, exercise, and insulin therapy. Learn about side effects, interactions and indications.

Average Savings for glyburide (generic): 25.06%
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Glyburide Drug Information:

Glyburide is an oral Diabetes medicine that helps control blood sugar levels. Glyburide is used together with diet and exercise to improve blood sugar control in adults with type 2 Diabetes mellitus. Glyburide is not for treating type 1 Diabetes. You should not use glyburide if you are being treated with Bosentan (Tracleer), or if you have Diabetic ketoacidosis (call your doctor for treatment). Glyburide is not for treating type 1 Diabetes. Before taking glyburide, tell your doctor if you are allergic to sulfa drugs, if you have been using insulin or chlorpropamide (Diabinese), or if you have hemolytic anemia (a lack of red blood cells), an enzyme deficiency (G6PD), a nerve disorder, liver disease, or kidney disease. Learn more

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Glyburide Side Effects

For the Consumer

Applies to glyburide: oral tablet

Along with its needed effects, glyburide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking glyburide:

Less common

  • Difficulty with swallowing
  • dizziness
  • fast heartbeat
  • hives
  • itching
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • shortness of breath
  • skin rash
  • tightness in the chest
  • unusual tiredness or weakness
  • wheezing


  • Abdominal or stomach pain
  • chills
  • clay-colored stools
  • dark urine
  • diarrhea
  • fever
  • headache
  • light-colored stools
  • loss of appetite
  • nausea and vomiting
  • rash
  • unpleasant breath odor
  • upper right abdominal pain
  • vomiting of blood
  • yellow eyes and skin

Incidence not known

  • Agitation
  • back, leg, or stomach pains
  • bleeding gums
  • blood in the urine or stools
  • bloody, black, or tarry stools
  • blurred vision
  • change in near or distance vision
  • chest pain
  • coma
  • confusion
  • convulsions
  • cough or hoarseness
  • decreased urine output
  • depression
  • difficulty in focusing eyes
  • difficulty with breathing
  • fast or irregular heartbeat
  • fluid-filled skin blisters
  • general body swelling
  • high fever
  • hostility
  • increased thirst
  • irritability
  • itching of the skin
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or sex organs
  • lethargy
  • lower back or side pain
  • muscle pain or cramps
  • muscle twitching
  • nosebleeds
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • rapid weight gain
  • seizures
  • sensitivity to the sun
  • skin thinness
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • stupor
  • swelling of the face, ankles, or hands
  • swollen or painful glands
  • unusual bleeding or bruising

Get emergency help immediately if any of the following symptoms of overdose occur while taking glyburide:

Symptoms of overdose

  • Anxiety
  • cold sweats
  • cool, pale skin
  • increased hunger
  • nervousness
  • nightmares
  • shakiness
  • slurred speech

Some side effects of glyburide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Indigestion
  • passing of gas

Incidence not known

  • Difficulty with moving
  • itching
  • joint pain
  • redness or other discoloration of the skin
  • severe sunburn
  • swollen joints

For Healthcare Professionals

Applies to glyburide: compounding powder, oral tablet


Like all sulfonylureas, this drug may commonly cause hypoglycemia and in some case it may be severe. Proper patient selection, dose, and patient instructions are important to avoid hypoglycemic episodes.



Very rare (less than 0.01%): Disulfiram-like reaction

Frequency not reported: Hypoglycemia, hyponatremia, weight gain, lactic acidosis, syndrome of inappropriate antidiuretic hormone (SIADH) secretion


Frequency not reported: Hepatic porphyria

Neonatal Diabetes:

Very common (10% or more): Hypoglycemia


Adverse gastrointestinal effects occur in about 1% to 2% of patients and appear to be dose related; they may subside following a dose reduction. Pancreatitis has been reported rarely.

Common (1% to 10%): Nausea, vomiting, epigastric fullness or sensation of pressure, abdominal pain, anorexia, dyspepsia, diarrhea, heartburn

Rare (less than 0.1%): Pancreatitis

Neonatal Diabetes:

Very common (10% or more): Transitory diarrhea, abdominal pain, vomiting, dyspepsia

Common (1% to 10%): Tooth discoloration


Very rare (less than 0.01%): Allergic vasculitis

Frequency not reported: Allergic skin reactions including pruritus, erythema, urticaria, and morbilliform or maculopapular eruptions, angioedema, arthralgia, myalgia, vasculitis, erythema multiforme, erythema nodosum, bullous eruptions, exfoliative dermatitis, photosensitivity, Stevens-Johnson syndrome

Allergic skin reactions including pruritus, erythema, urticaria, and morbilliform or maculopapular eruptions occurred in 1.5 % of patients during clinical trials. In some cases these were transient and disappeared despite continue therapy. Hypersensitivity reactions affecting the skin usually occur within the first 6 weeks of treatment with a sulfonylurea.



Common (1% to 10%): Allergic skin reactions including pruritus, erythema, urticaria, and morbilliform or maculopapular eruptions

Frequency not reported: Alopecia/hypotrichoses, increased sweating, facial edema, angioedema, bullous reactions, erythema multiforme, exfoliative dermatitis


-Frequency not reported: Porphyria cutanea tarda, photosensitivity reactions

Allergic skin reactions including pruritus, erythema, urticaria, morbilliform, erythematous and maculopapular and bullous skin eruptions or psoriasiform drug eruptions occurred in 1.5 % of patients during clinical trials. These may be transient and may disappear despite continued therapy. Bullous reactions, erythema multiforme, and exfoliative dermatitis have been reported. If skin reactions persist, this drug should be discontinued.


Changes in accommodation and/or blurred vision are thought to be related to fluctuations in glucose levels.

Frequency not reported: Changes in accommodation and/or blurred vision, diplopia, visual disturbances, blindness



Postmarketing reports: Hemolytic anemia


Frequency not reported: Leukopenia, agranulocytosis, thrombocytopenia, thrombocytopenia purpura, eosinophilia, bone marrow aplasia, coagulation disorders, hemolytic anemia, aplastic anemia, anemia, pancytopenia



Rare (less than 0.1%): Cholestatic jaundice, hepatitis

Frequency not reported: Liver function abnormalities including isolated transaminase elevations

Postmarketing reports:


Frequency not reported: Increased liver enzymes (AST, ALT), abnormal liver function, cholestasis, cholestatic hepatitis, granulomatous hepatitis, bilirubinemia

Neonatal Diabetes:

Very common (10% or more): Transient increased transaminases


Frequency not reported: Abnormal renal function, acute renal failure


Frequency not reported: Arthralgia, arthritis

Nervous system

Frequency not reported: Paresthesia, tremor, convulsions, encephalopathy, confusion, headache, cerebrovascular disorders


Frequency not reported: Deafness, fever


Frequency not reported: Acute psychosis

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.

Source: Drugs.com Glyburide (www.drugs.com/glyburide.html).