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Generic Name: glyburide (GLYE bue ride)
Brand Names: DiaBeta, glynase prestab, Micronase
Glyburide is an oral diabetes medicine that helps control blood sugar levels.
Glyburide is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.
Glyburide is not for treating type 1 diabetes.
You should not use glyburide if you are being treated with bosentan (Tracleer), or if you have diabetic ketoacidosis (call your doctor for treatment). Glyburide is not for treating type 1 diabetes.
Before taking glyburide, tell your doctor if you are allergic to sulfa drugs, if you have been using insulin or chlorpropamide (Diabinese), or if you have hemolytic anemia (a lack of red blood cells), an enzyme deficiency (G6PD), a nerve disorder, liver disease, or kidney disease.
Take care not to let your blood sugar get too low. Low blood sugar (hypoglycemia) can occur if you skip a meal, exercise too long, drink alcohol, or are under stress. Symptoms include headache, hunger, weakness, sweating, tremor, irritability, or trouble concentrating. Carry hard candy or glucose tablets with you in case you have low blood sugar. Other sugar sources include orange juice and milk. Be sure your family and close friends know how to help you in an emergency.
You should not use glyburide if you are allergic to it, or if:
you are being treated with bosentan (Tracleer);
you have type 1 diabetes; or
you have diabetic ketoacidosis (call your doctor for treatment).
Tell your doctor if you have ever had:
hemolytic anemia (a lack of red blood cells);
an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD);
a nerve disorder affecting bodily functions;
liver or kidney disease; or
an allergy to sulfa drugs.
Before taking glyburide, tell your doctor if you have taken another oral diabetes medicine or used insulin during the past 2 weeks.
Glyburide may increase your risk of serious heart problems, but not treating your diabetes can also damage your heart and other organs. Talk to your doctor about the risks and benefits of this medicine.
Follow your doctor's instructions about using this medicine if you are pregnant or breast-feeding a baby. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester of pregnancy.
You should not breast-feed while using glyburide.
Glyburide is usually taken with breakfast or the first main meal of the day.
Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose. Use the medicine exactly as directed.
Your blood sugar may need to be checked often, and you may need other blood tests at your doctor's office.
Low blood sugar (hypoglycemia) can happen to anyone who has diabetes. Symptoms include headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, and feeling anxious or shaky. To quickly treat low blood sugar, always keep a fast-acting source of sugar with you such as fruit juice, hard candy, crackers, raisins, or non-diet soda.
Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency.
Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination, blurred vision, headache, and tiredness.
Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.
If your doctor changes your brand, strength, or type of glyburide, your dosage needs may change. Ask your pharmacist if you have any questions about the new kind of glyburide you receive at the pharmacy.
Store at room temperature away from moisture and heat. Keep the bottle tightly closed when not in use.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A glyburide overdose can cause life-threatening hypoglycemia.
Symptoms of severe hypoglycemia include extreme weakness, nausea, tremors, sweating, confusion, trouble speaking, fast heartbeats, or seizure.
If you also take colesevelam, avoid taking it within 4 hours after you take glyburide.
Avoid drinking alcohol. It lowers blood sugar and may interfere with your diabetes treatment.
Glyburide could make you sunburn more easily. Avoid sunlight or tanning beds. Wear protective clothing and use sunscreen (SPF 30 or higher) when you are outdoors.
Get emergency medical help if you have signs of an allergic reaction to glyburide (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Call your doctor at once if you have:
dark urine, jaundice (yellowing of the skin or eyes);
severe skin rash, redness, or itching;
pale skin, easy bruising or bleeding;
fever, chills, sore throat, mouth sores; or
low levels of sodium in the bodyheadache, confusion, slurred speech, severe weakness, vomiting, loss of coordination, feeling unsteady.
Older adults may be more likely to have low blood sugar while taking glyburide.
Common glyburide side effects may include:
low blood sugar;
nausea, heartburn, feeling full;
muscle or joint pain;
blurred vision; or
mild rash or skin redness.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Usual Adult Dose for Diabetes Type 2:
Standard glyburide:
-Initial dose: 2.5 mg to 5 mg orally once a day
-Dose titration: Increase in increments of no more than 2.5 mg at weekly intervals based upon blood glucose response
-Maintenance dose: 1.25 to 20 mg orally as a single dose or in pided doses
-Maximum dose: 20 mg/day
Micronized glyburide:
-Initial dose: 1.5 mg to 3 mg orally once a day
-Dose titration: Increase in increments of no more than 1.5 mg at weekly intervals based upon blood glucose response
-Maintenance dose: 0.75 to 12 mg orally as a single dose or in pided doses
-Maximum dose: 12 mg/day
Comments:
-Administer with breakfast or the first main meal of the day
-Lower initial doses may be used in patients who are sensitive to hypoglycemic drugs
-Once a day therapy is generally satisfactory, however, some patients may have a more satisfactory response with twice-a-day dosing, especially those receiving higher doses.
TRANSFER FROM OTHER HYPOGLYCEMIC THERAPY:
-Oral Antidiabetic Therapy: No exact dosage relationships exists between standard glyburide, micronized glyburide, or other oral hypoglycemic agents; when transferring patients from other oral hypoglycemic therapy, the maximum starting doses should be observed.
-Insulin:
--If the insulin dose is less than 20 units per day substitute 2.5 to 5 mg (standard) OR 1.5 to 3 mg (micronized) orally once a day.
--If the insulin dose is between 20 and 40 units per day, substitute 5 mg (standard) OR 3 mg (micronized) orally once a day.
--If the insulin dose is more than 40 units per day; transition the patient by concomitantly decreasing insulin by 50% and starting glyburide at 5 mg (standard) OR 3 mg (micronized) orally once a day; as insulin is progressively withdrawn, titrate in increments of 1.25 to 2.5 mg (standard) OR 0.75 to 1.5 mg (micronized) orally once a day every 2 to 10 days.
Use: As an adjunct to diet and exercise to improve glycemic control in adults with type 2 diabetes mellitus.
Usual Geriatric Dose for Diabetes Type 2:
Initial dose: 1.25 to 2.5 mg (standard) orally or 0.75 to 1.5 mg (micronized) orally once a day.
Glyburide may not work as well when you use other medicines at the same time. Many other drugs can also affect blood sugar control. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
Further informationRemember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.
Source: Drugs.com Glyburide (www.drugs.com/glyburide.html).
Applies to glyburide: oral tablet
Along with its needed effects, glyburide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking glyburide:
Less common
Rare
Incidence not known
Get emergency help immediately if any of the following symptoms of overdose occur while taking glyburide:
Symptoms of overdose
Some side effects of glyburide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Less common
Incidence not known
For Healthcare Professionals
Applies to glyburide: compounding powder, oral tablet
GeneralLike all sulfonylureas, this drug may commonly cause hypoglycemia and in some case it may be severe. Proper patient selection, dose, and patient instructions are important to avoid hypoglycemic episodes.
MetabolicGlyburide:
Very rare (less than 0.01%): Disulfiram-like reaction
Frequency not reported: Hypoglycemia, hyponatremia, weight gain, lactic acidosis, syndrome of inappropriate antidiuretic hormone (SIADH) secretion
Sulfonylureas:
Frequency not reported: Hepatic porphyria
Neonatal Diabetes:
Very common (10% or more): Hypoglycemia
GastrointestinalAdverse gastrointestinal effects occur in about 1% to 2% of patients and appear to be dose related; they may subside following a dose reduction. Pancreatitis has been reported rarely.
Common (1% to 10%): Nausea, vomiting, epigastric fullness or sensation of pressure, abdominal pain, anorexia, dyspepsia, diarrhea, heartburn
Rare (less than 0.1%): Pancreatitis
Neonatal Diabetes:
Very common (10% or more): Transitory diarrhea, abdominal pain, vomiting, dyspepsia
Common (1% to 10%): Tooth discoloration
HypersensitivityVery rare (less than 0.01%): Allergic vasculitis
Frequency not reported: Allergic skin reactions including pruritus, erythema, urticaria, and morbilliform or maculopapular eruptions, angioedema, arthralgia, myalgia, vasculitis, erythema multiforme, erythema nodosum, bullous eruptions, exfoliative dermatitis, photosensitivity, Stevens-Johnson syndrome
Allergic skin reactions including pruritus, erythema, urticaria, and morbilliform or maculopapular eruptions occurred in 1.5 % of patients during clinical trials. In some cases these were transient and disappeared despite continue therapy. Hypersensitivity reactions affecting the skin usually occur within the first 6 weeks of treatment with a sulfonylurea.
DermatologicGlyburide:
Common (1% to 10%): Allergic skin reactions including pruritus, erythema, urticaria, and morbilliform or maculopapular eruptions
Frequency not reported: Alopecia/hypotrichoses, increased sweating, facial edema, angioedema, bullous reactions, erythema multiforme, exfoliative dermatitis
Sulfonylureas:
-Frequency not reported: Porphyria cutanea tarda, photosensitivity reactions
Allergic skin reactions including pruritus, erythema, urticaria, morbilliform, erythematous and maculopapular and bullous skin eruptions or psoriasiform drug eruptions occurred in 1.5 % of patients during clinical trials. These may be transient and may disappear despite continued therapy. Bullous reactions, erythema multiforme, and exfoliative dermatitis have been reported. If skin reactions persist, this drug should be discontinued.
OcularChanges in accommodation and/or blurred vision are thought to be related to fluctuations in glucose levels.
Frequency not reported: Changes in accommodation and/or blurred vision, diplopia, visual disturbances, blindness
HematologicGlyburide:
Postmarketing reports: Hemolytic anemia
Sulfonylureas:
Frequency not reported: Leukopenia, agranulocytosis, thrombocytopenia, thrombocytopenia purpura, eosinophilia, bone marrow aplasia, coagulation disorders, hemolytic anemia, aplastic anemia, anemia, pancytopenia
HepaticGlyburide:
Rare (less than 0.1%): Cholestatic jaundice, hepatitis
Frequency not reported: Liver function abnormalities including isolated transaminase elevations
Postmarketing reports:
Sulfonylureas:
Frequency not reported: Increased liver enzymes (AST, ALT), abnormal liver function, cholestasis, cholestatic hepatitis, granulomatous hepatitis, bilirubinemia
Neonatal Diabetes:
Very common (10% or more): Transient increased transaminases
RenalFrequency not reported: Abnormal renal function, acute renal failure
MusculoskeletalFrequency not reported: Arthralgia, arthritis
Nervous systemFrequency not reported: Paresthesia, tremor, convulsions, encephalopathy, confusion, headache, cerebrovascular disorders
OtherFrequency not reported: Deafness, fever
PsychiatricFrequency not reported: Acute psychosis
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/27/2021.
Source: Drugs.com Glyburide (www.drugs.com/glyburide.html).
September 25, 2020
August 27, 2020
August 6, 2020
August 6, 2020
July 26, 2021
July 26, 2021
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