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Glucagon

Generic Name: glucagon (nasal) (GLOO ka gon)
Brand Name: Baqsimi
Physician reviewed glucagon (nasal) (nasal) patient information - includes glucagon (nasal) description, dosage and directions.
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Drug Information:
Glucagon is a hormone that increases blood sugar levels. It also slows involuntary muscle movements of the stomach and intestines that aid in digestion. Glucagon nasal (for use in the nose) is used to treat severe hypoglycemia (low blood sugar) in adult and children at least 4 years old. Glucagon may also be used for purposes not listed in this medication guide. Glucagon should be used to treat hypoglycemia only if the person cannot eat, passes out, or is having a seizure. Be sure you know how to give glucagon nasal before you need to use it. Hypoglycemia should be treated as quickly as possible. Having low blood sugar for too long can cause seizure, coma, or death. Learn more

Glucagon Side Effects

Glucagon Side Effects

For the Consumer

Applies to glucagon: injection powder for solution

Along with its needed effects, glucagon may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking glucagon:

Rare

  • Anxiety
  • blurred vision
  • chills
  • cold sweats
  • coma
  • confusion
  • cool, pale skin
  • depression
  • dizziness
  • fast heartbeat
  • headache
  • increased hunger
  • nausea
  • nervousness
  • nightmares
  • seizures
  • shakiness
  • slurred speech
  • unusual tiredness or weakness

Incidence not known

  • Difficulty with swallowing
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • fast, pounding, or irregular heartbeat or pulse
  • hives, itching, or skin rash
  • pounding in the ears
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • slow or fast heartbeat
  • sweating
  • tightness in the chest

Some side effects of glucagon may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Vomiting

For Healthcare Professionals

Applies to glucagon: injectable powder for injection, nasal powder, subcutaneous solution

General

The more commonly reported adverse reactions have included nausea, vomiting, and headache; nasal and ocular symptoms including watery eyes and nasal congestion and itching have been reported with nasal administration.

Hypersensitivity

Very rare (less than 0.01%): Anaphylactic reactions

Frequency not reported: Generalized allergic reactions

Nervous system

Very common (10% or more): Headache (up to 18.3%)

Frequency not reported: Dysgeusia (nasal), parosmia (nasal)

Metabolic

Hypoglycemia/hypoglycemia coma have been reported in patients using this drug as a diagnostic aid, especially among those patients who have fasted.

Uncommon (0.1% to 1%): Hypoglycemia

Very rare (less than 0.01%): Hypoglycemia coma

Ocular

Watery eyes, itchy eyes, and eye redness were reported when adult patients were specifically questioned if these symptoms were present; some increase in symptom severity was reported by 58.8%, 21.6%, 24.8%, respectively. Symptom worsening of watery eyes, itchy eyes, and eye redness were reported by 47.2%, 16.7%, 13.9%, of pediatric patients, respectively.

Frequency not reported: Watery eyes, itchy eyes, redness of eyes

Gastrointestinal

Very common (10% or more): Nausea (up to 26.1%), vomiting (up to 15%)

Rare (less than 0.1%): Abdominal pain

Frequency not reported: Throat irritation (nasal)

Dermatologic

Frequency not reported: Pruritus

Postmarketing reports: Necrolytic migratory erythema (with continuous glucagon infusions)

Cardiovascular

Very rare (less than 0.01%): Bradycardia, tachycardia, hypotension, hypertension

Respiratory

Upper respiratory tract irritation including rhinorrhea, nasal discomfort, nasal congestion, cough, and epistaxis were reported in 12.4% of adult patients in pooled studies of IM and nasal glucagon. In pediatric studies, upper respiratory tract irritation including nasal discomfort, nasal congestion, and sneezing were reported in up to 16.7% of patients. When adult patients were questioned specifically if symptoms of nasal congestion, nasal itchiness, runny nose, sneezing, or itchy throat were present and worsened 42.5%, 39.2%, 34.6%, 19.6%, and 12.4% reported some increase in symptom severity, respectively; 41.7%, 27.8%, and 25% of pediatric patients reported some increase in symptom severity of nasal congestion, nasal itchiness, and runny nose, respectively.

Very common (10% or more): Upper respiratory tract irritation (up to 16.7%)

Frequency not reported: Nasal pruritus (nasal)

Other

Frequency not reported: Itching of ears

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Glucagon (www.drugs.com/mtm/glucagon-nasal.html).