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Glipizide is an oral diabetes medicine that helps control blood sugar levels by helping your pancreas produce insulin.
Glipizide is used together with diet and exercise to improve blood sugar control in adults with type 2 diabetes mellitus.
Glipizide is not for treating type 1 diabetes.
You should not use glipizide if you have diabetic ketoacidosis (call your doctor for treatment).
You should not use this medicine if you are allergic to glipizide, or if you have diabetic ketoacidosis (call your doctor for treatment).
Tell your doctor if you have ever had:
liver or kidney disease;
chronic diarrhea, or a blockage in your intestines; or
an enzyme deficiency called glucose-6-phosphate dehydrogenase deficiency (G6PD).
Follow your doctor's instructions about using this medicine if you are pregnant. Blood sugar control is very important during pregnancy, and your dose needs may be different during each trimester. You should not take glipizide during the last 2 weeks of pregnancy. Agents other than glipizide are currently recommended to treat diabetes in pregnant women.
It may not be safe to breast-feed while using this medicine. Ask your doctor about any risk.
Take glipizide exactly as prescribed by your doctor. Follow all directions on your prescription label. Your doctor may occasionally change your dose. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Take the regular tablet 30 minutes before your first meal of the day.
Take the glipizide extended-release tablet with your first meal of the day.
Swallow the tablet whole and do not crush, chew, or break it.
Your blood sugar may need to be checked often, and you may need other blood tests at your doctor's office.
Low blood sugar (hypoglycemia) can happen to anyone who has diabetes. Symptoms include headache, hunger, sweating, irritability, dizziness, nausea, fast heart rate, and feeling anxious or shaky. To quickly treat low blood sugar, always keep a fast-acting source of sugar with you such as fruit juice, hard candy, crackers, raisins, or non-diet soda.
Your doctor can prescribe a glucagon emergency injection kit to use in case you have severe hypoglycemia and cannot eat or drink. Be sure your family and close friends know how to give you this injection in an emergency.
Also watch for signs of high blood sugar (hyperglycemia) such as increased thirst or urination, blurred vision, headache, and tiredness.
Blood sugar levels can be affected by stress, illness, surgery, exercise, alcohol use, or skipping meals. Ask your doctor before changing your dose or medication schedule.
Some forms of glipizide are made with a shell that is not absorbed or melted in the body. Part of the tablet shell may appear in your stool. This is a normal side effect and will not make the medication less effective.
Store at room temperature away from moisture, heat, and light.
Take your dose as soon as you can, but only if you are getting ready to eat a meal. If you skip a meal, skip the missed dose and wait until your next meal. Do not take two doses at one time.
Get your prescription refilled before you run out of medicine completely.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. A glipizide overdose can cause life-threatening hypoglycemia.
Symptoms of severe hypoglycemia include extreme weakness, blurred vision, sweating, trouble speaking, tremors, stomach pain, confusion, and seizure (convulsions).
Avoid drinking alcohol. It lowers blood sugar and can cause side effects.
Avoid driving or operating machinery until you know how this medicine will affect you.
Get emergency medical help if you have signs of an allergic reaction to glipizide: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.
Call your doctor at once if you have symptoms of low blood sugar:
headache, irritability
sweating, fast heart rate;
dizziness, nausea; or
hunger, feeling anxious or shaky.
Common glipizide side effects may include:
diarrhea, constipation, gas;
dizziness, drowsiness;
tremors; or
skin rash, redness, or itching.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Sometimes it is not safe to use certain medications at the same time. Some drugs can affect your blood levels of other drugs you take, which may increase side effects or make the medications less effective.
Many drugs can interact with glipizide. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible interactions are listed here. Tell your doctor about all your current medicines and any medicine you start or stop using.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use glipizide only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Glipizide Er (www.drugs.com/glipizide.html).
Applies to glipizide: oral tablet, oral tablet extended release
Along with its needed effects, glipizide may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking glipizide:
Less common
Rare
Incidence not known
Some side effects of glipizide may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Rare
Incidence not known
Applies to glipizide: compounding powder, oral tablet, oral tablet extended release
The more commonly reported side effects have included dizziness, diarrhea, nervousness, tremor, hypoglycemia, and flatulence.
Disulfiram-like reactions have been reported with sulfonylureas. Clinical experience has shown this drug to have a low incidence of disulfiram-like alcohol reactions.
Common (1% to 10%): Hypoglycemia
Uncommon (less than 1%): Thirst
Frequency not reported: Disulfiram like reactions, hepatic porphyria, hyponatremia, syndrome of inappropriate antidiuretic hormone (SIADH), elevation of LDH
Frequency not reported: Leucopenia, agranulocytosis, thrombocytopenia, aplastic anemia, hemolytic anemia, pancytopenia
Common (1% to 10%): Syncope
Uncommon (less than 1%): Arrhythmia, flushing, hypertension
Frequency not reported: Impaired hepatic function, hepatitis, jaundice, mild to moderate ALT, LDH, alkaline phosphatase elevations
Postmarketing reports: Cholestatic and hepatocellular forms of liver injury accompanied by jaundice
Dermatologic side effects frequently disappear with continued therapy. Photosensitivity has been reported with other sulfonylureas.
Common (1% to 10%): Sweating, pruritus
Uncommon (less than 1%): Rash, urticaria
Frequency not reported: Rash, erythema, morbilliform or maculopapular eruptions, urticaria, pruritus, eczema
Common (1% to 10%): Nausea, diarrhea, constipation, gastralgia, vomiting, flatulence, dyspepsia
Uncommon (less than 1%): Anorexia, trace blood in stool
Frequency not reported: Gastrointestinal irritation, gastrointestinal bleeding
Postmarketing reports: Abdominal pain
Gastrointestinal side effects appear to be dose-related and may disappear on division or reduction of dosage.
Common (1% to 10%): Polyuria
Uncommon (less than 1%): Dysuria
Common (1% to 10%): Arthralgia, leg cramps, myalgia
Common (1% to 10%): Headache, dizziness, nervousness, tremors, paresthesia, hypesthesia
Uncommon (less than 1%): Migraine
Frequency not reported: Drowsiness
Common (1% to 10%): Blurred vision
Uncommon (less than 1%): Pain in the eye, conjunctivitis, retinal hemorrhage
Frequency not reported: Diplopia, abnormal vision, visual impairment, decreased vision
Common (1% to 10%): Asthenia, pain
Uncommon (less than 1%): Chills, edema
Frequency not reported: Vertigo, malaise
Common (1% to 10%): Insomnia, anxiety, depression
Frequency not reported: Confusion
Common (1% to 10%): Rhinitis
Uncommon (less than 1%): Pharyngitis, dyspnea
Frequency not reported: Mild to moderate BUN and creatinine elevations
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Glipizide Er (www.drugs.com/glipizide.html).
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