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Applies to glimepiride: oral tablet
Along with its needed effects, glimepiride may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking glimepiride:
Incidence not known
Get emergency help immediately if any of the following symptoms of overdose occur while taking glimepiride:
Symptoms of overdose
Some side effects of glimepiride may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
Incidence not known
For Healthcare Professionals
Applies to glimepiride: oral tabletGeneral
The most commonly reported adverse events included hypoglycemia, headache, nausea, asthenia, and dizziness.Metabolic
Hyponatremia and syndrome of inappropriate antidiuretic hormone secretion (SIADH) occurred in mostly in patients who were on other medications or who had medical conditions known to cause hyponatremia or increased release of antidiuretic hormone.
Very common (10% or more): Hypoglycemia (up to 19.7%)
Frequency not reported: Weight gain
Postmarketing reports: Hyponatremia, SIADHHematologic
Rare (less than 0.1%): Thrombocytopenia, leukopenia, agranulocytosis, granulocytopenia, erythropenia, aplastic anemia, pancytopenia
Postmarketing reports: Hemolytic anemia in patients without G6PD deficiency, thrombocytopenia purpuraHypersensitivity
Uncommon (0.1% to 1%): Allergic reactions such as pruritus, erythema, urticaria, a morbilliform or maculopapular eruptions
Frequency not reported: Cutaneous eruptions with or without pruritus, cross-allergenicity with sulfonylureas, sulfonamides, or related substances
Postmarketing reports: Anaphylaxis, angioedema, Stevens-Johnson syndrome, dyspneaOcular
Temporary visual impairment due to changes in blood glucose levels may occur due to temporary alteration in the turgidity and hence the refractive index of the lens which is dependent on blood glucose levels.
Frequency not reported: Transient visual disturbancesDermatologic
Dermatologic side effects have included pruritus, erythema, urticaria, and morbilliform or maculopapular rashes in less than 1% of cases. Sulfonylureas have caused porphyria cutanea tarda and photosensitivity reactions.Nervous system
Common (1% to 10%): Headache, dizzinessGastrointestinal
Rare (less than 0.1%): Nausea, vomiting, diarrhea, abdominal discomfort, abdominal pain, sensations of pressure or fullness in the epigastriumHepatic
Common (1% to 10%): Elevated ALT
Very rare (less than 0.01%): Hepatic function abnormal, hepatitis, hepatic failure
Postmarketing reports: Hepatitis and liver impairment, e.g. with cholestasis and jaundice, hepatic porphyria reactions and disulfiram-like reactionsImmunologic
Common (1% to 10%): Flu syndrome
Very rare (less than 0.01%): Leukocytoclastic vasculitisOther
Common (1% to 10%): Asthenia, accidental injury
Accidental injury was reported more frequently in patients receiving this drug (5.4% vs 3.4%). There was insufficient information available to determine if these events were associated with hypoglycemia.
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