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Gleostine

Generic Name: lomustine (LOE mus teen)
Brand Name: Gleostine
Physician reviewed Gleostine patient information - includes Gleostine description, dosage and directions.
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Drug Information:
Gleostine is a cancer medicine that interferes with the growth of cancer cells and slows their spread in the body. Gleostine is used to treat brain tumors in people who have already received surgery or radiation. This medicine is also used to treat Hodgkin's disease. Gleostine is sometimes given with other cancer medicines. Gleostine may also be used for purposes not listed in this medication guide. Gleostine can lower blood cells that help your body fight infections and help your blood to clot. Serious and sometimes fatal infections may occur up to 6 weeks after you are treated with Gleostine. Call your doctor if you have easy bruising, unusual bleeding (nose, mouth, vagina, or rectum), or signs of infection (fever, chills, body aches). Learn more

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Gleostine Side Effects

Note: This document contains side effect information about lomustine. Some of the dosage forms listed on this page may not apply to the brand name Gleostine.

For the Consumer

Applies to lomustine: oral capsule

Warning

Oral route (Capsule)

Lomustine causes delayed, dose-related, cumulative, fatal myelosuppression. Monitor blood counts for at least 6 weeks after each dose. Do not administer more than one dose every 6 weeks. Physician and pharmacist should emphasize to patient that overdosage can cause fatal toxicity.

Along with their needed effects, medicines like lomustine (the active ingredient contained in Gleostine) can sometimes cause unwanted effects such as blood problems, loss of hair, and other side effects; these are described below. Also, because of the way these medicines act on the body, there is a chance that they might cause other unwanted effects that may not occur until months or years after the medicine is used. These delayed effects may include certain types of cancer, such as leukemia. Discuss these possible effects with your doctor.

Along with its needed effects, lomustine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking lomustine:

More common

  • Bleeding gums
  • chest pain
  • shortness of breath
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Less common

  • Awkwardness
  • black, tarry stools
  • blood in the urine or stools
  • confusion
  • cough or hoarseness
  • decrease in urination
  • fever or chills
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • slurred speech
  • swelling of the feet or lower legs
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness

Incidence not known

  • Abdominal or stomach pain or tenderness
  • bone pain
  • change in frequency of urination or amount of urine
  • clay colored stools
  • dark urine
  • decreased appetite
  • dizziness
  • drowsiness
  • dry mouth
  • headache
  • increased blood pressure
  • increased thirst
  • itching
  • loss of appetite
  • nausea or vomiting
  • skin rash
  • weight gain
  • yellow eyes or skin

Some side effects of lomustine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

  • Darkening of the skin
  • diarrhea

Incidence not known

  • Blurred vision
  • changes in patterns and rhythms of speech
  • confusion about identity, place, and time
  • decreased vision
  • eye pain
  • hair loss or thinning of the hair
  • shakiness and unsteady walk
  • swelling or inflammation of the mouth
  • trouble with speaking
  • unsteadiness, trembling, or other problems with muscle control or coordination
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

For Healthcare Professionals

Applies to lomustine: oral capsule

Hematologic

Very common (10% or more): Decreased white blood counts (up to 65%), leukopenia

Frequency not reported: Myelosuppression/bone marrow suppression, thrombocytopenia, anemia, pancytopenia decreased hematocrit, bone marrow failure

Gastrointestinal

Very common (10% or more): Nausea and vomiting (45% to 100%)

Very rare (less than 0.01%): Diarrhea

Frequency not reported: Stomatitis, anorexia, loss of appetite

Hepatic

Rare (less than 0.1%): Cholestatic jaundice

Frequency not reported: Elevations in transaminases, alkaline phosphatase, and bilirubin levels

Renal

Frequency not reported: Progressive azotemia, decreased kidney size, renal failure, kidney damage, elevated BUN levels, renal atrophy, renal injury

Respiratory

Rare (less than 0.1%): Pulmonary toxicity, interstitial pneumonia, lung fibrosis

Frequency not reported: Lung infiltration

Oncologic

Frequency not reported: Acute leukemia, bone marrow dysplasia, myelodysplastic syndrome

Nervous system

Uncommon (0.1% to 1%): Apathy, disorientation, confusion, stuttering

Frequency not reported: Lethargy, ataxia, dysarthria, abnormal coordination

Ocular

Frequency not reported: Optic atrophy, visual disturbances (e.g., blindness)

Dermatologic

Frequency not reported: Alopecia

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Gleostine (www.drugs.com/mtm/gleostine.html).