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Geodon (ziprasidone) is an antipsychotic medication. It works by changing the effects of chemicals in the brain.
Geodon is used to treat schizophrenia and the manic symptoms of bipolar disorder (manic depression) in adults and children who are at least 10 years old. It is available as an oral (by mouth) treatment as an injection.
Geodon may also be used for purposes not listed in this medication guide.
You should not use Geodon if you have a heart rhythm disorder, a history of long QT syndrome, uncontrolled heart failure, if you have recently had a heart attack, or if you are allergic to Geodon or ziprasidone.
Some medicines can cause unwanted or dangerous effects when used with Geodon, and should not be used at the same time. Tell each of your health care providers about all medicines you use now and any medicine you start or stop using.
Stop taking Geodon and call your doctor right away if you have a chest pain, severe dizziness, and a fast or pounding heartbeat. These could be signs of a serious heart rhythm problem.
Stop taking Geodon and call your doctor right away if you have severe muscle pains, muscle spasms, fevers, sweating, or confusion.
Stop using this medicine and call your doctor right away if you have a new or worsening skin rash with fever or swollen glands.
Tell your doctor if you experience prolonged diarrhea or loose stools while taking Geodon.
You should not use Geodon if you are allergic to ziprasidone, or if you have:
a heart rhythm disorder;
a personal or family history of long QT syndrome;
uncontrolled or untreated heart failure; or
if you have recently had a heart attack.
Geodon is not approved for use in psychotic conditions related to dementia. Geodon may increase the risk of death in older adults with dementia-related conditions.
Geodon should never be taken together with any of the following drugs, or a life-threatening heart rhythm disorder could occur:
anagrelide;
methadone;
tacrolimus;
certain anti-nausea medicines including dolasetron, droperidol, or ondansetron;
the antibiotics azithromycin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, and pentamidine;
certain cancer medicines such as arsenic trioxide and vandetanib;
the antidepressants citalopram, escitalopram;
anti-malaria medications including chloroquine, halofantrine, mefloquine;
the following heart rhythm medicines - amiodarone, disopyramide, dofetilide, dronedarone, flecainide, ibutilide, quinidine, sotalol; or
certain anti-psychotics such as chlorpromazine, haloperidol, mesoridazine, pimozide, and thioridazine.
This list is not complete and there may be other drugs that should not be taken at the same time as Geodon. Tell your doctor about all medicines you use.
To make sure Geodon is safe for you, tell your doctor if you have ever had:
any heart problems;
a heart attack or stroke;
a bone marrow or blood cell disorder;
breast cancer;
low blood levels of potassium or magnesium;
diabetes (ziprasidone may raise your blood sugar);
seizures or epilepsy;
suicidal thoughts;
Alzheimer's disease;
trouble swallowing;
liver disease; or
kidney disease.
Tell your doctor if you are pregnant or plan to become pregnant during treatment.
Taking antipsychotic medication during the last 3 months of pregnancy may cause problems in the newborn, such as withdrawal symptoms, breathing problems, feeding problems, fussiness, tremors, and limp or stiff muscles. However, you may have withdrawal symptoms or other problems if you stop taking your medicine during pregnancy. If you become pregnant while taking Geodon, do not stop taking it without your doctor's advice.
It is not known whether Geodon passes into breast milk or if it could harm a nursing baby. Talk to your doctor about Geodon if you are planning to breastfeed.
Older adults may be more sensitive to the effects of this medicine.
Geodon is not approved for use by anyone younger than 18 years old.
Follow all directions on your prescription label. Do not take this medicine in larger or smaller amounts or for longer than recommended.
Take this medicine with food. Swallow the capsule whole.
While using Geodon, you may need frequent blood tests to check your kidney or liver function may.
If you are diabetic, check your blood sugar levels on a regular basis while you are taking Geodon.
Use Geodon regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
It may take several weeks before your symptoms improve. Do not stop using Geodon suddenly, even if you feel fine. Keep using the medication as directed and tell your doctor if your symptoms do not improve.
Store at room temperature away from moisture, light, and heat.
Read all patient information, medication guides, and instruction sheets provided to you. Ask your doctor or pharmacist if you have any questions.
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose symptoms may include cause excessive sleepiness, slurred speech, high blood pressure, shaking, tremors, or anxiety.
While you are taking Geodon, you may be more sensitive to temperature extremes such as very hot or cold conditions. Avoid getting too cold, or becoming overheated or dehydrated. Drink plenty of fluids, especially in hot weather and during exercise. It is easier to become dangerously overheated and dehydrated while you are taking Geodon.
Geodon may impair your thinking or reactions. Avoid driving or operating machinery until you know how this medicine will affect you. Avoid getting up too fast from a sitting or lying position, or you may feel dizzy. Dizziness or severe drowsiness can cause falls, fractures, or other injuries.
Avoid drinking alcohol. Dangerous side effects could occur.
Get emergency medical help if you have signs of an allergic reaction to Geodon: (hives, difficult breathing, swelling in your face or throat) or a severe skin reaction (fever, sore throat, burning in your eyes, skin pain, red or purple skin rash that spreads and causes blistering and peeling).
Seek medical treatment if you have a serious drug reaction that can affect many parts of your body. Symptoms may include: skin rash, fever, swollen glands, flu-like symptoms, muscle aches, severe weakness, unusual bruising, or yellowing of your skin or eyes. This reaction may occur several weeks after you began using ziprasidone.
Also call your doctor at once if you have:
dizziness or a light-headed feeling, like you might pass out;
chest pain, fast or pounding heartbeats;
uncontrolled muscle movements in your face (chewing, lip smacking, frowning, tongue movement, blinking or eye movement);
sudden weakness or ill feeling, fever, chills, sore throat, mouth sores, red or swollen gums, pain when swallowing;
increased thirst, increased urination, hunger, dry mouth, fruity breath odor, drowsiness, dry skin, blurred vision, weight loss; or
very stiff (rigid) muscles, high fever, sweating, confusion, agitation.
Common Geodon side effects may include:
dizziness, drowsiness, unusual tiredness;
nausea, upset stomach;
diarrhea, constipation;
changes in vision;
feeling restless;
tremors or twitching;
rash; or
runny nose, new or worsening cough.
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
Taking Geodon with other drugs that make you sleepy or slow your breathing can cause dangerous or life-threatening side effects. Ask your doctor before taking a sleeping pill, narcotic pain medicine, prescription cough medicine, a muscle relaxer, or medicine for anxiety, depression, or seizures.
Geodon should never be taken together with any of the following drugs, or a life-threatening heart rhythm disorder could occur;
anagrelide;
methadone;
tacrolimus;
certain anti-nausea medicines including dolasetron, droperidol, or ondansetron;
the antibiotics azithromycin, clarithromycin, erythromycin, levofloxacin, moxifloxacin, and pentamidine;
certain cancer medicines such as arsenic trioxide and vandetanib;
the antidepressants citalopram and escitalopram;
anti-malaria medications including chloroquine, halofantrine, mefloquine;
the following heart rhythm medicines - amiodarone, disopyramide, dofetilide, dronedarone, flecainide, ibutilide, quinidine, sotalol; or;
certain anti-psychotics such as chlorpromazine, haloperidol, mesoridazine, pimozide, and thioridazine;
Many other drugs can interact with Geodon. Not all possible interactions are listed here. Tell your doctor about all your medications and any you start or stop using during treatment with Geodon. This includes prescription and over-the-counter medicines, vitamins, and herbal products.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Geodon only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Geodon (www.drugs.com/geodon.html).
Note: This document contains side effect information about ziprasidone. Some of the dosage forms listed on this page may not apply to the brand name Geodon.
Common side effects of Geodon include: drowsiness, weight gain, dizziness, headache, and nausea. Other side effects include: respiratory system disorder, extrapyramidal reaction, orthostatic hypotension, and pain at injection site. See below for a comprehensive list of adverse effects.
Applies to ziprasidone: oral capsule
Other dosage forms:
Oral route (Capsule; Suspension)
Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death compared with placebo. Although the causes of death in clinical trials were varied, most of the deaths appeared to be either cardiovascular (eg, heart failure, sudden death) or infectious (eg, pneumonia) in nature. Observational studies suggest that antipsychotic drugs may increase mortality. It is unclear from these studies to what extent the mortality findings may be attributed to the antipsychotic drug as opposed to patient characteristics. Ziprasidone hydrochloride is not approved for the treatment of elderly patients with dementia-related psychosis.
Along with its needed effects, ziprasidone (the active ingredient contained in Geodon) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking ziprasidone:
More common
Less common
Rare
Incidence not known
Some side effects of ziprasidone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
Applies to ziprasidone: intramuscular powder for injection, oral capsule
The most commonly reported adverse events included somnolence, respiratory tract infections, extrapyramidal symptoms, dizziness, akathisia, abnormal vision, asthenia, vomiting, headache, and nausea.
Uncommon (0.1% to 1%): Thirst, increased appetite, hypercholesteremia, dehydration, hyperglycemia, hypokalemia
Rare (less than 0.1%): Hypocalcemia, hyperlipidemia, hyperkalemia, hypochloremia, hypoglycemia, hyponatremia, hypoproteinemia, gout, hyperchloremia, hyperuricemia, hypomagnesemia, ketosis
Weight gain of 7% or more was statistically significantly greater among patients with schizophrenia receiving ziprasidone in a pooled analysis of four 4 and 6 week placebo-controlled trials (10% versus 4%). The median weight gain was 0.5 kg among all ziprasidone patients compared with no weight gain in the placebo patients.
Very common (10% or more): Headache (18%), extrapyramidal symptoms (31%), somnolence (14%)
Common (1% to 10%): Akathisia, dizziness, dyskinesia, dystonia, headache, sedation, tremor, hypertonia, speech disorder
Uncommon (0.1% to 1%): Ataxia, bradykinesia, cogwheel rigidity, disturbance in attention, dizziness postural, drooling, dysarthria, generalized tonic-clonic seizures, hyperkinesia, hypersomnia, hypoesthesia, lethargy, oculogyric crisis, paresthesia, tardive dyskinesia, amnesia, buccoglossal syndrome, choreoathetosis, diplopia, incoordination, neuropathy
Rare (less than 0.1%): Akinesis, paresis, restless legs syndrome, torticollis, paralysis
Postmarketing reports: Facial droop, neuroleptic malignant syndrome, serotonin syndrome (alone or in combination with serotonergic products), tardive dyskinesia
Common (1% to 10%): Constipation, dry mouth, nausea, thick tongue, vomiting, dyspepsia, diarrhea, anorexia
Uncommon (0.1% to 1%): Gastrointestinal discomfort, salivary hypersecretion, dysphagia, flatulence, gastritis, rectal hemorrhage, tongue edema
Rare (less than 0.1%): Gastroesophageal reflux, loose stools, gum hemorrhage, fecal impaction, hematemesis, leukoplakia of mouth, melena
Postmarketing reports: Dysphagia, swollen tongue
Common (1% to 10%): Respiratory tract infection, increased cough, rhinitis
Uncommon (0.1% to 1%): Dyspnea, sore throat, pneumonia, epistaxis
Rare (less than 0.1%): Hiccups, hemoptysis, laryngismus
Collective data gathered from 17 placebo-controlled clinical studies (n=5106) involving the use of atypical antipsychotic agents for the treatment of behavioral disorders in the elderly patient with dementia showed a risk of death 1.6 to 1.7 times greater in the drug-treated patient than in the placebo-treated patient. The average length of duration for the trials was 10 weeks with the cause of death in the majority of cases, though not all, reported as either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature. Although ziprasidone was not included in these studies, the consistent findings across all three relevant chemical classes support the opinion that these findings are likely to be applicable to all atypical antipsychotic agents. Ziprasidone is not approved by the FDA for use in the treatment of behavioral disorders in elderly patients with dementia.
Collective data gathered from 17 placebo-controlled clinical studies (n=5106) involving the use of atypical antipsychotic agents for the treatment of behavioral disorders in the elderly patient with dementia showed a risk of death 1.6 to 1.7 times greater in the drug-treated patient than in the placebo-treated patient. The average length of duration for the trials was 10 weeks with the cause of death in the majority of cases, though not all, reported as either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature. Although ziprasidone (the active ingredient contained in Geodon) was not included in these studies, the consistent findings across all three relevant chemical classes support the opinion that these findings are likely to be applicable to all atypical antipsychotic agents. Ziprasidone is not indicated for use in the treatment of behavioral disorders in elderly patients with dementia.
In a study evaluating the QT prolonging effect of oral ziprasidone with other drugs used in the treatment of schizophrenia, the mean increase in QTc from baseline ranged from 9 to 14 seconds which was greater than 4 of the comparator drugs (risperidone, olanzapine, quetiapine, and haloperidol) but was approximately 14 seconds less than thioridazine.
Common (1% to 10%): Chest pain, tachycardia, postural hypotension, hypertension
Uncommon (0.1% to 1%): Right bundle branch block, palpitation, bradycardia, angina pectoris, atrial fibrillation, peripheral edema
Rare (less than 0.1%): ECG QTc prolonged, increased pulse, first degree AV block, bundle branch block, phlebitis, pulmonary embolism, cardiomegaly, cerebral infarct, cerebrovascular accident, deep thrombophlebitis, myocarditis, thrombophlebitis
Postmarketing reports: Torsades de pointes, postural hypotension, hypotension, syncope, venous thromboembolism
Postmarketing reports: Allergic reaction
Common (1% to 10%): Rash, fungal dermatitis, face edema, photosensitivity reaction, sweating
Uncommon (0.1% to 1%): Acne, maculopapular rash, urticaria, eczema, exfoliative dermatitis, vesiculobullous rash
Rare (less than 0.1%): Alopecia, dermatitis allergic, erythema, psoriasis, skin irritation, swelling face, rash papular
Frequency not reported: Severe cutaneous adverse reactions, such as Stevens-Johnson syndrome
Postmarketing reports: Angioedema, rash, Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)
Common (1% to 10%): Restlessness, insomnia, agitation
Uncommon (0.1% to 1%): Anxiety, throat tightness, nightmare
Rare (less than 0.1%): Anorgasmia, bradyphrenia, flat affect, panic attack, sleep walking
Postmarketing reports: Mania/hypomania
Common (1% to 10%): Blurred vision, abnormal vision
Uncommon (0.1% to 1%): Photophobia, conjunctivitis, dry eyes, blepharitis, cataract
Rare (less than 0.1%): Amblyopia, eye pruritus, visual disturbance, eye hemorrhage, visual field defect, keratitis, keratoconjunctivitis
Uncommon (0.1% to 1%): Impotence, abnormal ejaculation, female lactation,
Rare (less than 0.1%): Erectile dysfunction, increased erection, galactorrhea, gynecomastia, hypothyroidism, hyperthyroidism, thyroiditis, female sexual dysfunction
Postmarketing reports: Priapism
Common (1% to 10%): Musculoskeletal stiffness, myalgia
Uncommon (0.1% to 1%): Joint stiffness, muscle cramps, extremity pain, tenosynovitis
Rare (less than 0.1%): Arthropathy, musculoskeletal discomfort, trismus, myopathy
Uncommon (0.1% to 1%): Dysuria, urinary incontinence, amenorrhea, hematuria, menorrhagia, polyuria, urinary retention metrorrhagia
Rare (less than 0.1%): vaginal hemorrhage, nocturia, oliguria, uterine hemorrhage
Postmarketing reports: Enuresis, urinary incontinence
Uncommon (0.1% to 1%): Anemia, ecchymosis, leukocytosis, leukopenia, eosinophilia, lymphadenopathy
Rare (less than 0.1%): Lymphopenia, increased eosinophil count, abnormal eosinophil count, thrombocytopenia, hypochromic anemia, lymphocytosis, monocytosis, basophilia, lymphedema, polycythemia, thrombocythemia
Uncommon (0.1% to 1%): Hepatic enzyme increased, alkaline phosphatase increased, Rare (less than 0.1%): Abnormal liver function test, jaundice, gamma glutamyl transpeptidase increased, cholestatic jaundice, hepatitis, hepatomegaly, fatty liver deposit
Common (1% to 10%): Asthenia, accidental injury, fatigue, fever, chills, hypothermia
Uncommon (0.1% to 1%): Abnormal gait, tinnitus
Rare (less than 0.1%): Ear pain, vertigo positional, body temperature increased
Local side effects associated with intramuscular ziprasidone (the active ingredient contained in Geodon) have frequently included pain at the injection site.
Common (1% to 10%): Flu syndrome
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Geodon (www.drugs.com/geodon.html).
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March 27, 2020
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