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Geodon

Generic Name: ziprasidone (zi PRAY si done)
Brand Names: Geodon
Geodon is used to treat schizophrenia and the manic symptoms of bipolar disorder. Learn about side effects, interactions and indications.

Average Savings for ziprasidone hcl (generic): 51.96%
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Drug Information:
Geodon (ziprasidone) is an antipsychotic medication. It works by changing the effects of chemicals in the brain. Geodon is used to treat schizophrenia and the manic symptoms of bipolar disorder (manic depression) in adults and children who are at least 10 years old. It is available as an oral (by mouth) treatment as an injection. Geodon may also be used for purposes not listed in this medication guide. You should not use Geodon if you have a heart rhythm disorder, a history of long QT syndrome, uncontrolled heart failure, if you have recently had a heart attack, or if you are allergic to Geodon or ziprasidone. Learn more

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Geodon Side Effects

Note: This document contains side effect information about ziprasidone. Some of the dosage forms listed on this page may not apply to the brand name Geodon.

In Summary

Common side effects of Geodon include: drowsiness, weight gain, dizziness, headache, and nausea. Other side effects include: respiratory system disorder, extrapyramidal reaction, orthostatic hypotension, and pain at injection site. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to ziprasidone: oral capsule

Other dosage forms:

  • intramuscular powder for solution

Warning

Oral route (Capsule; Suspension)

Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death compared with placebo. Although the causes of death in clinical trials were varied, most of the deaths appeared to be either cardiovascular (eg, heart failure, sudden death) or infectious (eg, pneumonia) in nature. Observational studies suggest that antipsychotic drugs may increase mortality. It is unclear from these studies to what extent the mortality findings may be attributed to the antipsychotic drug as opposed to patient characteristics. Ziprasidone hydrochloride is not approved for the treatment of elderly patients with dementia-related psychosis.

Along with its needed effects, ziprasidone (the active ingredient contained in Geodon) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking ziprasidone:

More common

  • Cough
  • difficulty with speaking
  • drooling
  • fear or nervousness
  • fever
  • inability to sit still
  • loss of balance control
  • muscle trembling, jerking, or stiffness
  • need to keep moving
  • restlessness
  • shuffling walk
  • sneezing
  • sore throat
  • stiffness of the limbs
  • twisting movements of the body
  • uncontrolled movements, especially of the face, neck, and back

Less common

  • Blurred vision
  • body aches or pain
  • chest pain
  • congestion
  • dizziness
  • fast, pounding, or irregular heartbeat or pulse
  • headache
  • hoarseness
  • pounding in the ears
  • runny nose
  • slow or fast heartbeat
  • swelling of the tongue
  • tender, swollen glands in the neck
  • trouble with swallowing
  • voice changes

Rare

  • Dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • persistent, painful erection
  • seizures

Incidence not known

  • Inability to move the eyes
  • increased blinking or spasms of the eyelid
  • sticking out of tongue
  • trouble with breathing
  • uncontrolled twisting movements of the neck, trunk, arms, or legs
  • unusual facial expressions

Some side effects of ziprasidone may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Acid or sour stomach
  • belching
  • constipation
  • diarrhea
  • heartburn
  • indigestion
  • lack or loss of strength
  • nausea
  • rash
  • stomach discomfort, upset, or pain
  • weakness
  • weight gain

Less common

  • Blistering, crusting, irritation, itching, or reddening of the skin
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in vision
  • cracked, dry, or scaly skin
  • depression
  • difficulty with moving
  • dry mouth
  • increase in salivation
  • itching or reddening of the skin
  • joint pain
  • loss of appetite
  • muscle ache
  • muscle pains or stiffness
  • muscle tightness
  • stuffy nose
  • swelling
  • swollen joints
  • vomiting
  • weakness of the arms and legs
  • weight loss

For Healthcare Professionals

Applies to ziprasidone: intramuscular powder for injection, oral capsule

General

The most commonly reported adverse events included somnolence, respiratory tract infections, extrapyramidal symptoms, dizziness, akathisia, abnormal vision, asthenia, vomiting, headache, and nausea.

Metabolic

Uncommon (0.1% to 1%): Thirst, increased appetite, hypercholesteremia, dehydration, hyperglycemia, hypokalemia

Rare (less than 0.1%): Hypocalcemia, hyperlipidemia, hyperkalemia, hypochloremia, hypoglycemia, hyponatremia, hypoproteinemia, gout, hyperchloremia, hyperuricemia, hypomagnesemia, ketosis

Weight gain of 7% or more was statistically significantly greater among patients with schizophrenia receiving ziprasidone in a pooled analysis of four 4 and 6 week placebo-controlled trials (10% versus 4%). The median weight gain was 0.5 kg among all ziprasidone patients compared with no weight gain in the placebo patients.

Nervous system

Very common (10% or more): Headache (18%), extrapyramidal symptoms (31%), somnolence (14%)

Common (1% to 10%): Akathisia, dizziness, dyskinesia, dystonia, headache, sedation, tremor, hypertonia, speech disorder

Uncommon (0.1% to 1%): Ataxia, bradykinesia, cogwheel rigidity, disturbance in attention, dizziness postural, drooling, dysarthria, generalized tonic-clonic seizures, hyperkinesia, hypersomnia, hypoesthesia, lethargy, oculogyric crisis, paresthesia, tardive dyskinesia, amnesia, buccoglossal syndrome, choreoathetosis, diplopia, incoordination, neuropathy

Rare (less than 0.1%): Akinesis, paresis, restless legs syndrome, torticollis, paralysis

Postmarketing reports: Facial droop, neuroleptic malignant syndrome, serotonin syndrome (alone or in combination with serotonergic products), tardive dyskinesia

Gastrointestinal

Common (1% to 10%): Constipation, dry mouth, nausea, thick tongue, vomiting, dyspepsia, diarrhea, anorexia

Uncommon (0.1% to 1%): Gastrointestinal discomfort, salivary hypersecretion, dysphagia, flatulence, gastritis, rectal hemorrhage, tongue edema

Rare (less than 0.1%): Gastroesophageal reflux, loose stools, gum hemorrhage, fecal impaction, hematemesis, leukoplakia of mouth, melena

Postmarketing reports: Dysphagia, swollen tongue

Respiratory

Common (1% to 10%): Respiratory tract infection, increased cough, rhinitis

Uncommon (0.1% to 1%): Dyspnea, sore throat, pneumonia, epistaxis

Rare (less than 0.1%): Hiccups, hemoptysis, laryngismus

Collective data gathered from 17 placebo-controlled clinical studies (n=5106) involving the use of atypical antipsychotic agents for the treatment of behavioral disorders in the elderly patient with dementia showed a risk of death 1.6 to 1.7 times greater in the drug-treated patient than in the placebo-treated patient. The average length of duration for the trials was 10 weeks with the cause of death in the majority of cases, though not all, reported as either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature. Although ziprasidone was not included in these studies, the consistent findings across all three relevant chemical classes support the opinion that these findings are likely to be applicable to all atypical antipsychotic agents. Ziprasidone is not approved by the FDA for use in the treatment of behavioral disorders in elderly patients with dementia.

Cardiovascular

Collective data gathered from 17 placebo-controlled clinical studies (n=5106) involving the use of atypical antipsychotic agents for the treatment of behavioral disorders in the elderly patient with dementia showed a risk of death 1.6 to 1.7 times greater in the drug-treated patient than in the placebo-treated patient. The average length of duration for the trials was 10 weeks with the cause of death in the majority of cases, though not all, reported as either cardiovascular (e.g., heart failure, sudden death) or infectious (e.g., pneumonia) in nature. Although ziprasidone (the active ingredient contained in Geodon) was not included in these studies, the consistent findings across all three relevant chemical classes support the opinion that these findings are likely to be applicable to all atypical antipsychotic agents. Ziprasidone is not indicated for use in the treatment of behavioral disorders in elderly patients with dementia.

In a study evaluating the QT prolonging effect of oral ziprasidone with other drugs used in the treatment of schizophrenia, the mean increase in QTc from baseline ranged from 9 to 14 seconds which was greater than 4 of the comparator drugs (risperidone, olanzapine, quetiapine, and haloperidol) but was approximately 14 seconds less than thioridazine.

Common (1% to 10%): Chest pain, tachycardia, postural hypotension, hypertension

Uncommon (0.1% to 1%): Right bundle branch block, palpitation, bradycardia, angina pectoris, atrial fibrillation, peripheral edema

Rare (less than 0.1%): ECG QTc prolonged, increased pulse, first degree AV block, bundle branch block, phlebitis, pulmonary embolism, cardiomegaly, cerebral infarct, cerebrovascular accident, deep thrombophlebitis, myocarditis, thrombophlebitis

Postmarketing reports: Torsades de pointes, postural hypotension, hypotension, syncope, venous thromboembolism

Hypersensitivity

Postmarketing reports: Allergic reaction

Dermatologic

Common (1% to 10%): Rash, fungal dermatitis, face edema, photosensitivity reaction, sweating

Uncommon (0.1% to 1%): Acne, maculopapular rash, urticaria, eczema, exfoliative dermatitis, vesiculobullous rash

Rare (less than 0.1%): Alopecia, dermatitis allergic, erythema, psoriasis, skin irritation, swelling face, rash papular

Frequency not reported: Severe cutaneous adverse reactions, such as Stevens-Johnson syndrome

Postmarketing reports: Angioedema, rash, Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)

Psychiatric

Common (1% to 10%): Restlessness, insomnia, agitation

Uncommon (0.1% to 1%): Anxiety, throat tightness, nightmare

Rare (less than 0.1%): Anorgasmia, bradyphrenia, flat affect, panic attack, sleep walking

Postmarketing reports: Mania/hypomania

Ocular

Common (1% to 10%): Blurred vision, abnormal vision

Uncommon (0.1% to 1%): Photophobia, conjunctivitis, dry eyes, blepharitis, cataract

Rare (less than 0.1%): Amblyopia, eye pruritus, visual disturbance, eye hemorrhage, visual field defect, keratitis, keratoconjunctivitis

Endocrine

Uncommon (0.1% to 1%): Impotence, abnormal ejaculation, female lactation,

Rare (less than 0.1%): Erectile dysfunction, increased erection, galactorrhea, gynecomastia, hypothyroidism, hyperthyroidism, thyroiditis, female sexual dysfunction

Postmarketing reports: Priapism

Musculoskeletal

Common (1% to 10%): Musculoskeletal stiffness, myalgia

Uncommon (0.1% to 1%): Joint stiffness, muscle cramps, extremity pain, tenosynovitis

Rare (less than 0.1%): Arthropathy, musculoskeletal discomfort, trismus, myopathy

Genitourinary

Uncommon (0.1% to 1%): Dysuria, urinary incontinence, amenorrhea, hematuria, menorrhagia, polyuria, urinary retention metrorrhagia

Rare (less than 0.1%): vaginal hemorrhage, nocturia, oliguria, uterine hemorrhage

Postmarketing reports: Enuresis, urinary incontinence

Hematologic

Uncommon (0.1% to 1%): Anemia, ecchymosis, leukocytosis, leukopenia, eosinophilia, lymphadenopathy

Rare (less than 0.1%): Lymphopenia, increased eosinophil count, abnormal eosinophil count, thrombocytopenia, hypochromic anemia, lymphocytosis, monocytosis, basophilia, lymphedema, polycythemia, thrombocythemia

Hepatic

Uncommon (0.1% to 1%): Hepatic enzyme increased, alkaline phosphatase increased, Rare (less than 0.1%): Abnormal liver function test, jaundice, gamma glutamyl transpeptidase increased, cholestatic jaundice, hepatitis, hepatomegaly, fatty liver deposit

Other

Common (1% to 10%): Asthenia, accidental injury, fatigue, fever, chills, hypothermia

Uncommon (0.1% to 1%): Abnormal gait, tinnitus

Rare (less than 0.1%): Ear pain, vertigo positional, body temperature increased

Local

Local side effects associated with intramuscular ziprasidone (the active ingredient contained in Geodon) have frequently included pain at the injection site.

Immunologic

Common (1% to 10%): Flu syndrome

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Geodon (www.drugs.com/geodon.html).