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Commonly reported side effects of gemfibrozil include: malignant neoplasm, pancreatitis, dyspepsia, and cholelithiasis. Other side effects include: abdominal pain. See below for a comprehensive list of adverse effects.
For the ConsumerApplies to gemfibrozil: oral tablet
Along with its needed effects, gemfibrozil may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.
Check with your doctor immediately if any of the following side effects occur while taking gemfibrozil:
More common
Incidence not known
Some side effects of gemfibrozil may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:
More common
Less common
For Healthcare Professionals
Applies to gemfibrozil: compounding powder, oral tablet
GeneralThe most frequently reported side effects were gastrointestinal reactions and included dyspepsia, abdominal pain, diarrhea, nausea, vomiting, acute appendicitis, constipation, and flatulence.
GastrointestinalVery common (10% or more): Dyspepsia (19.6%)
Common (1% to 10%): Abdominal pain, acute appendicitis, diarrhea, nausea, vomiting, constipation, flatulence
Rare (less than 0.1%): Pancreatitis
Frequency not reported: Colitis
Nervous systemCommon (1% to 10%): Headache
Rare (less than 0.1%): Peripheral neuropathy, paresthesia, dizziness, somnolence
Frequency not reported: Peripheral neuritis, convulsions, syncope, hyperesthesia, taste perversion, intracerebral hemorrhage
HepaticRare (less than 0.1%): Hepatitis, cholestatic jaundice, cholelithiasis, cholecystitis, hepatic function abnormal
Frequency not reported: ALT increased, AST increased, bilirubin increased, alkaline phosphatase increased
CardiovascularUncommon (0.1% to 1%): Atrial fibrillation
Frequency not reported: Extrasystoles, vasculitis, peripheral vascular disease
DermatologicCommon (1% to 10%): Eczema, rash
Rare (less than 0.1%): Angioedema, urticaria, exfoliative dermatitis, dermatitis, pruritus, alopecia, photosensitivity reaction
OtherCommon (1% to 10%): Fatigue, vertigo
Rare (less than 0.1%): Creatine phosphokinase increased
Frequency not reported: Weight loss, viral infections, bacterial infections
MusculoskeletalRare (less than 0.1%): Myopathy, myalgia, painful extremities, arthralgia, synovitis, rhabdomyolysis, myositis, muscular weakness
Frequency not reported: Lupus-like syndrome, myasthenia
HematologicRare (less than 0.1%): Bone marrow failure, severe anemia, thrombocytopenia, leukopenia, eosinophilia, hemoglobin decreased, hematocrit decreased, WBC decreased
Frequency not reported: Anemia, bone marrow hypoplasia
OcularRare (less than 0.1%): Blurred vision
Frequency not reported: Retinal edema, cataracts
GenitourinaryRare (less than 0.1%): Erectile dysfunction
Frequency not reported: Impotence, male fertility decreased
PsychiatricRare (less than 0.1%): Libido decreased, depression
Frequency not reported: Confusion
RespiratoryRare (less than 0.1%): Laryngeal edema
RenalFrequency not reported: Renal dysfunction, renal failure
OncologicFrequency not reported: Hepatoma
ImmunologicFrequency not reported: Positive antinuclear antibody, anaphylaxis
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/3/2022.
Source: Drugs.com Gemfibrozil (www.drugs.com/gemfibrozil.html).
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