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Gastrografin

Generic Name: Diatrizoate Meglumine and Diatrizoate Sodium (dye a tri ZOE ate MEG loo meen & dye a tri ZOE ate SOW dee um)
Brand Name: Gastrografin, MD-76 R, MD-Gastroview
Easy-to-read patient leaflet for Gastrografin. Includes indications, proper use, special instructions, precautions, and possible side effects.
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Drug Information:
All products: Oral liquid: This is not a list of all drugs or health problems that interact with Gastrografin (diatrizoate meglumine and diatrizoate sodium). Tell your doctor and pharmacist about all of your drugs (prescription or OTC, natural products, vitamins) and health problems. You must check to make sure that it is safe for you to take Gastrografin (diatrizoate meglumine and diatrizoate sodium) with all of your drugs and health problems. Do not start, stop, or change the dose of any drug without checking with your doctor. Learn more

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Gastrografin Side Effects

Note: This document contains side effect information about diatrizoate. Some of the dosage forms listed on this page may not apply to the brand name Gastrografin.

For the Consumer

Applies to diatrizoate: intravenous solution

Along with its needed effects, diatrizoate (the active ingredient contained in Gastrografin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking diatrizoate:

Incidence not known

  • Blood in the urine
  • convulsions
  • cough
  • decrease in the amount of urine
  • difficulty with swallowing
  • dizziness
  • fast heartbeat
  • hives, itching, or rash
  • not able to pass urine
  • pain or burning while urinating
  • puffiness or swelling of the eyelids or around the eyes, face, lips, or tongue
  • shortness of breath
  • tightness in the chest
  • unusual tiredness or weakness

For Healthcare Professionals

Applies to diatrizoate: injectable powder for injection, injectable solution, oral powder for reconstitution, oral and rectal solution

General

The most frequently reported adverse reactions were vomiting, nausea, diarrhea, erythema, a sensation of pain, and a general feelings of warmth on intravascular administration.

Cardiovascular

Common (1% to 10%) Transient disturbance in heart rate, blood pressure, disturbance in cardiac rhythm or function, cardiac arrest

Uncommon (0.1% to 1%): Thrombophlebitis, venous thrombosis

Rare (0.01% to 0.1%): Thromboembolic events, myocardial infarction

Very rare (less than 0.01%): Severe hypotension and collapse; circulatory failure; ventricular fibrillation

Frequency not reported: Tachycardia, shock, hypotension, hypertension, reflex tachycardia, cyanosis

Gastrointestinal

Common (1% to 10%): Nausea, vomit, diarrhea

Frequency not reported: Diarrhea (ceases as soon as the intestine has been emptied); existing enteritis or colitis may be temporarily exacerbated; in case of obstruction, the prolonged contact with bowel mucosa can lead to erosions and to bowel necrosis; intestinal perforation; abdominal pain; oral mucosal blistering

Hypersensitivity

Common (1% to 10%): Anaphylactoid reactions (mild angioedema, conjunctivitis, coughing pruritus, rhinitis, sneezing, urticarial)

Respiratory

Common (1% to 10%): Transient disturbances in respiratory rate, dyspnea, respiratory distress, cough

Rare (less than 0.1%): Respiratory arrest, pulmonary edema

Frequency not reported: Bronchospasm, medication aspiration, pulmonary edema following aspiration, aspiration pneumonia, sneezing, laryngeal spasm

Endocrine

Uncommon (0.1% to 1%): Thyroid function tests indicative of hypothyroidism or transient thyroid suppression in adults and pediatric patients (including infants)

Frequency not reported: Hyperthyroidism

Dermatologic

Rare (less than 0.1%): Toxic epidermal necrolysis, urticaria, rash, pruritus, erythema, face edema, mucocutaneous syndrome (e.g. Stevens-Johnson's or Lyell syndrome)

Frequency not reported: Sweating, mild angioedema

Nervous system

Very rare (less than 0.01%): Convulsions, cerebral symptoms

Frequency not reported: Disturbances in consciousness, dizziness, headache, tremor, somnolence, transient paresis (vision or facial muscle paresis and epileptic fits), amnesia, photophobia, temporary states of agitation or confusion

Genitourinary

Frequency not reported: Perforation of the urethra, genitourinary tract infections, oliguria, hematuria, anuria

Local

Frequency not reported: Local pain, edema

Metabolic

Frequency not reported: Fluid and electrolyte imbalance

Ocular

Frequency not reported: Lacrimation, temporary blindness

Other

Frequency not reported: Pyrexia, sweating, chills, blanching, weakness, gagging and feeling suffocated, gasping, edema, cramp, malaise

Renal

Frequency not reported: Temporary renal failure

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Gastrografin (www.drugs.com/cdi/gastrografin.html).