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Galantamine Hydrobromide

Galantamine hydrobromide Prescription
Generic Name: galantamine (ga LAN ta meen)
Brand Name: Razadyne, Razadyne ER, Reminyl
Physician reviewed galantamine patient information - includes galantamine description, dosage and directions.
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Galantamine Hydrobromide Drug Information:

Galantamine improves the function of nerve cells in the brain. It works by preventing the breakdown of a chemical called acetylcholine (ah see til KO leen). People with dementia usually have lower levels of this chemical, which is important for the processes of memory, thinking, and reasoning. Galantamine is used to treat mild to moderate Alzheimer's type dementia. Galantamine may also be used for purposes not listed in this medication guide. Follow all directions on your medicine label and package. Tell each of your healthcare prOviders about all your medical conditions, allergies, and all medicines you use. Learn more

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Galantamine Hydrobromide Side Effects

In Summary

Commonly reported side effects of galantamine include: nausea and vomiting. Other side effects include: dizziness, dyspepsia, fatigue, headache, weight loss, diarrhea, and anorexia. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to galantamine: oral capsule extended release, oral solution, oral tablet

Side effects requiring immediate medical attention

Along with its needed effects, galantamine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking galantamine:

Less common

  • Chest pain or discomfort
  • lightheadedness, dizziness, or fainting
  • shakiness in the legs, arms, hands, or feet
  • shortness of breath
  • slow or irregular heartbeat
  • unusual tiredness

Rare

  • Blurred vision
  • confusion
  • decreased urination
  • dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position
  • dry mouth
  • fainting
  • fast, irregular, pounding, or racing heartbeat or pulse
  • feeling of warmth
  • rapid breathing
  • redness of the face, neck, arms, and occasionally, upper chest
  • sunken eyes
  • sweating
  • thirst
  • troubled breathing
  • unusual tiredness or weakness
  • wrinkled skin

Incidence not known

  • Blistering, peeling, or loosening of the skin
  • chills
  • cough
  • dark urine
  • fever
  • general tiredness and weakness
  • headache
  • hoarseness
  • irritation
  • joint pain, stiffness, or swelling
  • light-colored stools
  • nausea and vomiting
  • nervousness
  • pounding in the ears
  • rash, hives, or itching skin
  • red skin lesions, often with a purple center
  • red, irritated eyes
  • redness of the skin
  • swelling of the eyelids, face, lips, hands, or feet
  • tightness in the chest
  • troubled swallowing
  • upper right abdominal or stomach pain
  • yellow eyes and skin

Get emergency help immediately if any of the following symptoms of overdose occur while taking galantamine:

Symptoms of overdose

  • Confusion
  • convulsions
  • irregular, fast or slow, or shallow breathing
  • muscle weakness
  • pale or blue lips, fingernails, or skin
  • severe nausea
  • stomach cramps
  • sweating
  • tearing of the eyes
  • twitches of the muscle visible under the skin
  • vomiting
Side effects not requiring immediate medical attention

Some side effects of galantamine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Decreased appetite
  • weight loss

Less common

  • Acid or sour stomach
  • belching
  • discouragement
  • feeling sad or empty
  • general feeling of discomfort or illness
  • heartburn
  • increased sweating
  • indigestion
  • irritability
  • lack of appetite
  • lack or loss of strength
  • loss of interest or pleasure
  • muscle spasms
  • stomach discomfort, upset, or pain
  • trouble concentrating
  • trouble sleeping
  • unusual drowsiness, dullness, tiredness, weakness, or feeling of sluggishness

Rare

  • Burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • change in taste
  • dry heaves
  • loss of taste
  • unusually deep sleep
  • unusually long duration of sleep

Incidence not known

  • Continuing ringing or buzzing or other unexplained noise in the ears
  • hearing loss
  • seeing, hearing, or feeling things that are not there

For Healthcare Professionals

Applies to galantamine: oral capsule extended release, oral solution, oral tablet

Cardiovascular

Common (1% to 10%): Syncope, bradycardia

Frequency not reported: First degree atrioventricular (AV) block, palpitations, sinus bradycardia, supraventricular extrasystoles, flushing, hypotension

Postmarketing reports: Complete AV block, hypertension

Two randomized, placebo controlled trials revealed increased deaths in galantamine-treated patients with mild cognitive impairment. A total of 13 deaths occurred among galantamine-treated patients (n=1026) and 1 patient on placebo (n=1022). The deaths were due to various causes; about half of the galantamine deaths appeared to result from various vascular causes (myocardial infarction, stroke, and sudden death).

Dermatologic

Frequency not reported: Hyperhidrosis

Postmarketing reports: Stevens-Johnson syndrome, Acute generalized exanthematous pustulosis, Erythema multiforme

Gastrointestinal

Very common (10% or more): Nausea, vomiting

Common (1% to 10%): Diarrhea, abdominal pain, upper abdominal pain, dyspepsia, stomach discomfort, abdominal discomfort

Uncommon (0.1% to 1%): Retching

Postmarketing reports: Upper and lower GI bleeding, stomach discomfort, and abdominal discomfort.

The median duration of nausea in clinical trials was 5 to 7 days. The most commonly occurring adverse reactions associated with discontinuation have include nausea (6.2%), vomiting (3.3%), decreased appetite (1.5%), and dizziness (1.3%).

General

The most common side effects associated with discontinuation were nausea, vomiting, decreased appetite, dizziness, diarrhea, headache, and decreased appetite.

Genitourinary

Common (1% to 10%): Urinary tract infection, hematuria

Frequency not reported: Increased libido

Hematologic

Common (1% to 10%): Anemia

Hepatic

Postmarketing reports: Hepatitis, increased hepatic enzymes

Hypersensitivity

Postmarketing reports: Hypersensitivity

Metabolic

Common (1% to 10%): Decreased appetite, decreased weight, anorexia

Uncommon (0.1% to 1%): Dehydration

Musculoskeletal

Common (1% to 10%): Muscle spasms

Uncommon (0.1% to 1%): Muscular weakness

Nervous system

Common (1% to 10%): Headache, dizziness, tremor, somnolence, lethargy

Frequency not reported: Dysgeusia, hypersomnia, paresthesia

Postmarketing reports: Seizures

Ocular

Uncommon (0.1% to 1%): Blurred vision

Other

Common (1% to 10%): Fatigue, asthenia, malaise

Uncommon (0.1% to 1%): Fall

Postmarketing reports: Tinnitus

Psychiatric

Common (1% to 10%): Depression

Frequency not reported: Apathy, paranoia (disagreeable or terrifying dreams), paranoid reaction, increased libido, delirium, suicidal ideation and suicide

Postmarketing reports: Hallucination, visual hallucination, auditory hallucination

Respiratory

Common (1% to 10%): Rhinitis

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Galantamine Hydrobromide (www.drugs.com/mtm/galantamine.html).