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Generic Name: tiagabine (tye AG a been)
Brand Name: Gabitril
Physician reviewed Gabitril patient information - includes Gabitril description, dosage and directions.
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Drug Information:
Gabitril is an anti-epileptic medication, also called an anticonvulsant. Gabitril is used in combination with other medications to treat partial seizures in adults and children who are at least 12 years old. Gabitril may also be used for purposes not listed in this medication guide. Call your doctor at once if you have new or worsening seizures. Do not stop using Gabitril suddenly. Stopping suddenly may cause increased seizures. You should not use Gabitril if you are allergic to it. Tell your doctor about all other seizure medications you currently use. The safest dose of tiagabine may depend what other medicines you take in combination with it. Learn more

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Gabitril Side Effects

Note: This document contains side effect information about tiagabine. Some of the dosage forms listed on this page may not apply to the brand name Gabitril.

For the Consumer

Applies to tiagabine: oral tablet

Along with its needed effects, tiagabine (the active ingredient contained in Gabitril) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor as soon as possible if any of the following side effects occur while taking tiagabine:

More common

  • Blue or purple spots on skin
  • difficulty in concentrating or paying attention

Less common

  • Burning, numbness, or tingling sensations
  • clumsiness or unsteadiness
  • confusion
  • itching
  • mental depression
  • speech or language problems


  • Agitation
  • bloody or cloudy urine
  • burning, pain, or difficulty in urinating
  • frequent urge to urinate
  • generalized weakness
  • hostility
  • memory problems
  • quick to react or overreact emotionally
  • rash
  • uncontrolled back-and-forth and/or rolling eye movements
  • walking in unusual manner

Symptoms of overdose

  • Agitation (severe)
  • clumsiness or unsteadiness (severe)
  • coma
  • confusion (severe)
  • drowsiness (severe)
  • increase in seizures
  • mental depression
  • severe muscle twitching or jerking
  • sluggishness
  • speech problems (severe)
  • weakness

Some side effects of tiagabine may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Chills
  • diarrhea
  • dizziness
  • drowsiness
  • fever
  • headache
  • muscle aches or pain
  • nervousness
  • sore throat
  • tremor
  • unusual tiredness or weakness
  • vomiting

Less common

  • Abdominal pain
  • flushing
  • impaired vision
  • increased appetite
  • increased cough
  • mouth ulcers
  • muscle weakness
  • nausea
  • pain
  • trouble in sleeping

For Healthcare Professionals

Applies to tiagabine: oral tablet


Very common (10% or more): Common (1% to 10%): Rash, pruritus

Uncommon (0.1% to 1%): Dermatitis bullous dermatitis, bruising

Frequency not reported: Vesiculobullous rash, exfoliative dermatitis


Common (1% to 10%): Vasodilation


Very common (10% or more): Nausea (11%)

Common (1% to 10%): Abdominal pain, diarrhea, vomiting, increased appetite, mouth ulceration


Very rare (less than 0.01%): Abnormal hepatic function (elevated SGPT, GGT)


Common (1% to 10%): Myasthenia, muscle twitching


Very common (10% or more): Infection (15%)

Common (1% to 10%): Influenza syndrome

Nervous system

Very common (10% or more): Dizziness (27%), asthenia (20%), somnolence (18%), nervousness (10%), tremor

Common (1% to 10%): Ataxia, paresthesia, abnormal gait, nystagmus, speech disorder

Uncommon (0.1% to 1%): Nonconvulsive status epilepticus

Frequency not reported: Encephalopathy


Very common (10% or more): Blurred vision, visual field defects

Common (1% to 10%): Amblyopia, diplopia


Common (1% to 10%): Pharyngitis, cough, rhinitis


Common (1% to 10%): Difficulty with concentration/attention, insomnia, confusion, memory loss, depressed mood, emotional liability, hostility/aggression, agitation

Uncommon (0.1% to 1%): Depression, psychosis

Rare (0.01% to 0.1%): Hallucinations, delusion


Very common (10% or more): Accidental injury (17%)

Common (1% to 10%): Pain (unspecified), fatigue

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Gabitril (www.drugs.com/mtm/gabitril.html).