Generic Name: levoleucovorin (LEE voe LOO koe voe rin)
Brand Name: Fusilev, Khapzory
What is Fusilev?
Fusilev is used to treat or prevent toxic effects of methotrexate in people who have received methotrexate to treat bone cancer.
Fusilev is also used to treat or prevent toxic effects of methotrexate in people whose bodies do not eliminate methotrexate properly after the drug is metabolized. This medicine may also be used to treat toxic effects of an overdose or methotrexate or certain other medications.
Fusilev is also used in combination chemotherapy with fluorouracil to treat colorectal cancer that has spread to other parts of the body. This medicine treats only the symptoms of colorectal cancer but does not treat the cancer itself.
Fusilev should not be used to treat anemia that is caused by a lack of vitamin B12.
Fusilev may also be used for purposes not listed in this medication guide.
You should not be treated with Fusilev if you are allergic to Fusilev or to folic acid or folinic acid.
Before taking this medicine
You should not be treated with this medicine if you are allergic to Fusilev, folic acid, or folinic acid.
If possible, before you receive Fusilev, tell your doctor or caregivers if you have:
liver disease; or
if you are dehydrated.
It is not known whether this medicine will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant.
It may not be safe to breastfeed while using this medicine. Ask your doctor about any risk.
In an emergency, you may not be able to tell caregivers if you are pregnant or breast feeding. Make sure any doctor caring for your pregnancy or your baby knows you received this medicine.
How is Fusilev given?
Fusilev is given as an infusion into a vein. A healthcare provider will give you this injection.
For use with methotrexate, Fusilev is usually given every 3 to 6 hours.
For colorectal cancer, Fusilev is usually given daily as a 5-day treatment, repeated every 4 to 5 weeks.
After treatment with Fusilev, you will be watched to make sure Fusilev has been effective.
You will need frequent medical tests to help your doctor determine how long to treat you with Fusilev.
What happens if I miss a dose?
If this medication is given by a healthcare professional in an clinical setting, you are not likely to miss a dose.
If you are receiving Fusilev daily in 4-week treatment cycles, call your doctor for instructions if you miss an appointment for your scheduled injection.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.
What should I avoid while receiving Fusilev?
Follow your doctor's instructions about any restrictions on food, beverages, or activity.
Fusilev side effects
Get emergency medical help if you have signs of an allergic reaction: hives; difficult breathing; swelling of your face, lips, tongue, or throat.
Tell your doctor or caregivers at once if you have:
blisters or ulcers in your mouth, red or swollen gums, trouble swallowing;
severe ongoing nausea, vomiting, or diarrhea;
a light-headed feeling, like you might pass out;
dehydration symptoms--feeling very thirsty or hot, being unable to urinate, heavy sweating, or hot and dry skin; or
kidney problems--little or no urination; painful or difficult urination; swelling in your feet or ankles.
Common side effects may include:
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
What other drugs will affect Fusilev?
Tell your doctor about all your other medicines, especially:
a multivitamin or mineral supplement than contains folic acid; or
a sulfa drug (Bactrim, Septra, Sulfatrim, SMX-TMP or SMZ-TMP, and others).
This list is not complete. Other drugs may affect Fusilev, including prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.
Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use this medication only for the indication prescribed.
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Editorial References and Review
Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.
Source: Drugs.com Fusilev (www.drugs.com/mtm/fusilev.html).