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Fulvestrant Prescription
Generic Name: fulvestrant (ful VES trant)
Brand Name: Faslodex
Physician reviewed fulvestrant patient information - includes fulvestrant description, dosage and directions.
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Fulvestrant Drug Information:

Fulvestrant is used in postmenopausal women with hormone-related breast cancer that is advanced or has spread to other parts of the body (metastatic). Fulvestrant is used alone or in combination with another medicine called ribociclib (Kisqali) to treat HR-positive, HER2-negative breast cancer in: women with no prior treatment; or women whose cancer has progressed after treatment with anti-estrogen medication. Fulvestrant is used in combination with palbociclib (Ibrance) or abemaciclib (Verzenio) when the cancer has progressed after treatment with anti-estrogen medication. Learn more

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Fulvestrant Side Effects

For the Consumer

Applies to fulvestrant: intramuscular solution

Side effects requiring immediate medical attention

Along with its needed effects, fulvestrant may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking fulvestrant:

More common

  • Black, tarry stools
  • bleeding gums
  • bloating or swelling of the face, arms, hands, lower legs, or feet
  • blood in the urine or stools
  • burning, crawling, itching, numbness, prickling, "pins and needles", or tingling feelings
  • chest pain or tightness
  • chills
  • cloudy urine
  • cough
  • difficulty breathing
  • fainting
  • fever
  • hoarseness
  • irregular heartbeat, recurrent
  • lower back or side pain
  • painful or difficult urination
  • pale skin
  • pinpoint red spots on the skin
  • rapid weight gain
  • sore throat
  • sores, ulcers, or white spots on the lips or in the mouth
  • tender, swollen glands in the neck
  • tingling of the hands or feet
  • trouble with swallowing
  • troubled breathing with exertion
  • unusual bleeding or bruising
  • unusual tiredness or weakness
  • unusual weight gain or loss

Less common

  • Anxiety
  • confusion
  • dizziness or lightheadedness
  • fast heartbeat
  • mood or mental changes
  • muscle cramps in the hands, arms, feet, legs, or face
  • numbness and tingling around the mouth, fingertips, or feet
  • pain in the chest, groin, or legs, especially the calves
  • pain, redness, or swelling in the arm or leg
  • seizures
  • severe, sudden headache
  • slurred speech
  • stomach cramps
  • sudden loss of coordination
  • sudden, severe weakness or numbness in the arm or leg
  • tremor
  • vision changes

Incidence not known

  • Dark urine
  • flushing or redness of the skin
  • general feeling of tiredness or weakness
  • headache
  • hives or welts, itching, skin rash
  • large, hive-like swelling on the face, eyelids, lips, tongue, throat, hands, legs, feet, or genitals
  • light-colored stools
  • nausea
  • stomach pain, continuing
  • upper right abdominal pain
  • vaginal bleeding
  • vomiting
  • yellow eyes or skin
Side effects not requiring immediate medical attention

Some side effects of fulvestrant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

  • Back pain
  • bladder pain
  • body aches or pain
  • bone pain
  • change in or loss of taste
  • constipation
  • decreased appetite
  • depression
  • diarrhea
  • difficulty having a bowel movement
  • difficulty with moving
  • dry skin
  • dryness or soreness of the throat
  • feeling of warmth or heat
  • feeling sad or empty
  • frequent urge to urinate
  • general feeling of discomfort or illness
  • hair loss or thinning of hair
  • irritability
  • joint pain
  • lack or loss of appetite
  • lack or loss of strength
  • loss of interest or pleasure
  • muscle aches and pains
  • muscle stiffness
  • pain at the injection site
  • pain in the arms or legs
  • pelvic pain
  • shivering
  • stomach pain
  • sudden sweating
  • trouble concentrating
  • voice changes
  • weight loss

Less common

  • Dry eye
  • dry mouth
  • increased tearing
  • nervousness
  • swelling or redness in the joints

Incidence not known

  • Feeling of constant movement of self or surroundings
  • sensation of spinning

For Healthcare Professionals

Applies to fulvestrant: intramuscular solution


Very common (10% or more): Nausea (up to 34%), stomatitis (up to 28%), diarrhea (up to 24%), vomiting (up to 19%), abdominal pain (up to 12%)

Common (1% to 10%): Constipation


Very common (10% or more): Neutropenia (up to 83%), leukopenia (up to 53%), anemia (up to 30%), thrombocytopenia (up to 23%)

Common (1% to 10%): Reduced platelet count

Uncommon (0.1% to 1%): Leukorrhea, febrile neutropenia


Very common (10% or more): Vasodilation(up to 18%), hot flushes

Common (1% to 10%): Venous thromboembolism


Very common (10% or more): Bone pain (up to 16%), muscle pain, joint pain

Common (1% to 10%): Back pain, pain in extremity

Nervous system

Very common (10% or more): Headache (up to 15%)

Common (1% to 10%): Sciatica, peripheral neuropathy, dysgeusia, dizziness, paresthesia

Uncommon (0.1% to 1%): Neuralgia


Very common (10% or more): Pharyngitis (up to 16%), dyspnea (up to 15%)

Common (1% to 10%): Epistaxis, cough, chest pain


Very common (10% or more): Pelvic Pain (up to 10%)

Common (1% to 10%): Urinary tract infection, vaginal hemorrhage

Uncommon (0.1% to 1%): Vaginal moniliasis


Very common (10% or more): Alopecia (up to 18%), rash (up to 17%)

Common (1% to 10%): Dry skin, sweating, pruritus


Very common (10% or more): Hypersensitivity reactions

Uncommon (0.1% to 1%): Anaphylaxis


Very common (10% or more): Elevated hepatic enzymes (ALT, AST, ALP)

Common (1% to 10%): Elevated bilirubin

Uncommon (0.1% to 1%): Hepatic failure, hepatitis, elevated gamma-GT


Very common (10% or more): Infections (up to 47%)

Common (1% to 10%): Influenza syndrome


Very common (10% or more): Injection site pain (up to 12%), injection site reaction

Common (1% to 10%):

Uncommon (0.1% to 1%): Injection site hemorrhage, injection site hematoma


Common (1% to 10%): Increased lacrimation, blurred vision, dry eye


Very common (10% or more): Anorexia (up to 16%)

Common (1% to 10%): Peripheral edema


Common (1% to 10%): Insomnia, depression, anxiety


Very common (10% or more): Fatigue (up to 41%), pain (up to 19%), pyrexia (up to 13%)

Common (1% to 10%): Asthenia

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Fulvestrant (www.drugs.com/mtm/fulvestrant.html).