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Fragmin

Generic Name: dalteparin (DAL te PAR in)
Brand Names: Fragmin
Fragmin is an anticoagulant used to prevent blood clots such as deep vein thrombosis, which can lead to clots in the lungs. Learn about side effects, interactions and indications.
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Drug Information:
Fragmin (dalteparin) is an anticoagulant that helps prevent the formation of blood clots. Fragmin is used together with Aspirin to prevent blood vessel complications in people with certain types of angina (chest pain) or heart attack. Fragmin is used to prevent a type of blood clot called deep vein thrombosis (DVT), which can lead to blood clots in the lungs (pulmonary embolism). A DVT can occur after certain types of surgery, or in people who are bed-Ridden due to a prolonged illness. Fragmin is used long-term to treat a type of blood clot called venous thromboembolism (VTE) in people with cancer. Learn more

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Fragmin Side Effects

Note: This document contains side effect information about dalteparin. Some of the dosage forms listed on this page may not apply to the brand name Fragmin.

In Summary

Common side effects of Fragmin include: pain at injection site. Other side effects include: hematoma at injection site and increased serum alanine aminotransferase. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to dalteparin: subcutaneous solution

Warning

Subcutaneous route (Solution)

Patients anticoagulated with low molecular weight heparins or heparinoids who receive neuraxial anesthesia or undergo a spinal puncture are at risk for epidural or spinal hematomas, which may result in long-term or permanent paralysis. The use of indwelling epidural catheters, concomitant drugs that also affect hemostasis (eg, NSAIDs, platelet inhibitors, or other anticoagulants), history of traumatic or repeated epidural or spinal punctures, or history of spinal deformity or spinal surgery further increase this risk. The optimal timing of dalteparin administration and a neuraxial procedure is unknown. Frequent monitoring for signs and symptoms of neurological impairment is recommended. Seek urgent treatment if neurological compromise occurs.

Along with its needed effects, dalteparin (the active ingredient contained in Fragmin) may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking dalteparin:

More common

  • Deep, dark purple bruise, pain, or swelling at the injection site

Less common

  • Bleeding of the gums
  • coughing up blood
  • difficulty with breathing or swallowing
  • dizziness
  • headache
  • increased menstrual flow or vaginal bleeding
  • nosebleeds
  • paralysis
  • prolonged bleeding from cuts
  • red or black, tarry stools
  • red or dark brown urine
  • unexplained pain, swelling, or discomfort, especially in the chest, abdomen or stomach, joints, or muscles
  • unusual bruising
  • vomiting of blood or material that looks like coffee grounds
  • weakness

Rare

  • Back pain
  • bleeding from mucous membranes
  • bluish or black discoloration, flushing, or redness of the skin
  • burning, pricking, tickling, or tingling sensation
  • coughing
  • feeling faint
  • fever
  • leg weakness
  • numbness
  • problems with bowel or bladder function
  • skin rash (which may consist of pinpoint, purple-red spots), hives, or itching
  • sloughing of the skin at the injection site
  • swelling of the eyelids, face, or lips
  • tightness in the chest

For Healthcare Professionals

Applies to dalteparin: subcutaneous solution

General

The most common side effects were any bleeding, postoperative transfusion, transaminase increases, and injection site pain.

Cardiovascular

Very common (10% or more): Any bleeding (up to 18.5%)

Common (1% to 10%): Major bleeding reactions

Postmarketing reports: Prosthetic cardiac valve thrombosis

A bleeding reaction was considered major if accompanied by a decrease in hemoglobin of 2 g/dL or greater in connection with clinical symptoms, a transfusion was required, bleeding led to interruption of treatment or death, bleeding caused a significant clinical event, bleeding resulted in reoperation, or retroperitoneal or intracranial bleeding occurred.

Other

Very common (10% or more): Postoperative transfusion (up to 15.9%)

Common (1% to 10%): Wound hematoma, reoperation due to bleeding

Hepatic

Very common (10% or more): Grades 2 through 4 increases in AST and ALT (up to 14%)

Common (1% to 10%): Asymptomatic increases in transaminase levels (serum glutamic oxaloacetic transaminase/AST and Serum glutamic pyruvic transaminase/ALT) greater than 3 times the upper limit of normal, grades 3 and 4 increases in AST and ALT

Nervous system

Postmarketing reports: Epidural/spinal hematoma, intracranial bleed

Local

Very common (10% or more): Injection site pain (up to 12%)

Common (1% to 10%): Injection site hematoma

Hematologic

Common (1% to 10%): Reversible non-immunologically-mediated thrombocytopenia (type I)

Rare (less than 0.1%): Immunologically-mediated heparin-induced thrombocytopenia (type II, with or without associated thrombotic complications)

Genitourinary

Common (1% to 10%): Hematuria

Immunologic

Uncommon (0.1% to 1%): Allergic reaction

Rare (less than 0.1%): Fever

Frequency not reported: Anaphylactoid reaction

Dermatologic

Uncommon (0.1% to 1%): Rash, urticaria, pruritus

Rare (less than 0.1%): Bullous eruptions, skin necrosis, alopecia

Hypersensitivity

Uncommon (0.1% to 1%): Hypersensitivity

Metabolic

Uncommon (0.1% to 1%): Hyperkalemia

Musculoskeletal

Uncommon (0.1% to 1%): Osteoporosis

Endocrine

Postmarketing reports: Hypoaldosteronism

Gastrointestinal

Frequency not reported: Gastrointestinal bleeding

Postmarketing reports: Retroperitoneal bleed

Renal

Frequency not reported: Serum creatinine increased

Editorial References and Review

Medically reviewed by USARx EDITORIAL TEAM Last updated on 1/1/2020.

Source: Drugs.com Fragmin (www.drugs.com/fragmin.html).